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NameTyrosine-protein phosphatase non-receptor type 18
Synonyms
  • 3.1.3.48
  • BDP1
  • Brain-derived phosphatase
Gene NamePTPN18
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008999|Tyrosine-protein phosphatase non-receptor type 18
MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKN
RYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
EFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTF
QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLC
TVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNAS
PHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKR
GAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSP
AGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV
Number of residues460
Molecular Weight50481.995
Theoretical pINot Available
GO Classification
Functions
  • non-membrane spanning protein tyrosine phosphatase activity
Processes
  • peptidyl-tyrosine dephosphorylation
  • protein dephosphorylation
Components
  • cytoplasm
  • nucleus
General FunctionNon-membrane spanning protein tyrosine phosphatase activity
Specific FunctionDifferentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99952
UniProtKB Entry NamePTN18_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013556|Tyrosine-protein phosphatase non-receptor type 18 (PTPN18)
ATGAGCCGCAGCCTGGACTCGGCGCGGAGCTTCCTGGAGCGGCTGGAAGCGCGGGGCGGC
CGGGAGGGGGCAGTCCTCGCCGGCGAGTTCAGCAAAAGGTGTGAGCGGTACTGGGCCCAG
GAGCAGGAGCCACTGCAGACTGGGCTTTTCTGCATCACTCTGATAAAGGAGAAGTGGCTG
AATGAGGACATCATGCTCAGGACCCTCAAGGTCACATTCCAGAAGGAGTCCCGTTCTGTG
TACCAGCTACAGTATATGTCCTGGCCAGACCGTGGGGTCCCCAGCAGTCCTGACCACATG
CTCGCCATGGTGGAGGAAGCCCGTCGCCTCCAGGGATCTGGCCCTGAACCCCTCTGTGTC
CACTGCAGTGCGGGTTGTGGGCGAACAGGCGTCCTGTGCACCGTGGATTATGTGAGGCAG
CTGCTCCTGACCCAGATGATCCCACCTGACTTCAGTCTCTTTGATGTGGTCCTTAAGATG
AGGAAGCAGCGGCCTGCGGCCGTGCAGACAGAGGAGCAGTACAGGTTCCTGTACCACACG
GTGGCTCAGATGTTCTGCTCCACACTCCAGAATGCCAGCCCCCACTACCAGAACATCAAA
GAGAATTGTGCCCCACTCTACGACGATGCCCTCTTCCTCCGGACTCCCCAGGCACTTCTC
GCCATACCCCGCCCACCAGGAGGGGTCCTCAGGAGCATCTCTGTGCCCGGGTCCCCGGGC
CACGCCATGGCTGACACCTACGCGGTGGTGCAGAAGCGCGGGGCTCCAGCGGGCGCCGGG
AGTGGGACGCAGACGGGGACGGGGACGGGGACGGGGGCGCGCAGCGCGGAGGAGGCGCCG
CTCTACAGCAAGGTGACGCCGCGCGCCCAGCGACCCGGGGCGCACGCGGAGGACGCGAGG
GGGACGCTGCCTGGCCGCGTTCCTGCTGACCAAAGTCCTGCCGGATCTGGCGCCTACGAG
GACGTGGCGGGTGGAGCTCAGACCGGTGGGCTAGGTTTCAACCTGCGCATTGGGAGGCCG
AAGGGTCCCCGGGACCCGCCTGCTGAGTGGACCCGGGTGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9649
Chromosome Location2
LocusNot Available
References
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  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332
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