NamePotassium voltage-gated channel subfamily S member 3
Synonyms
  • Delayed-rectifier K(+) channel alpha subunit 3
  • Voltage-gated potassium channel subunit Kv9.3
Gene NameKCNS3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017657|Potassium voltage-gated channel subfamily S member 3
MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
VDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDIC
NTTSLENCTAK
Number of residues491
Molecular Weight56000.32
Theoretical pINot Available
GO Classification
Functions
  • potassium channel regulator activity
  • delayed rectifier potassium channel activity
Processes
  • potassium ion transmembrane transport
  • protein homooligomerization
  • potassium ion transport
  • synaptic transmission
  • small molecule metabolic process
  • energy reserve metabolic process
  • regulation of insulin secretion
Components
  • cytoplasm
  • plasma membrane
  • voltage-gated potassium channel complex
  • Golgi apparatus
  • integral component of membrane
General FunctionPotassium channel regulator activity
Specific FunctionPotassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).
Pfam Domain Function
Transmembrane Regions183-204 221-243 255-275 286-306 322-343 385-413
GenBank Protein IDNot Available
UniProtKB IDQ9BQ31
UniProtKB Entry NameKCNS3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017658|Potassium voltage-gated channel subfamily S member 3 (KCNS3)
ATGGTGTTTGGTGAGTTTTTCCATCGCCCTGGACAAGACGAGGAACTTGTCAACCTGAAT
GTGGGGGGCTTTAAGCAGTCTGTTGACCAAAGCACCCTCCTGCGGTTTCCTCACACCAGA
CTGGGGAAGCTGCTTACTTGCCATTCTGAAGAGGCCATTCTGGAGCTGTGTGATGATTAC
AGTGTGGCCGATAAGGAATACTACTTTGATCGGAATCCCTCCTTGTTCAGATATGTTTTG
AATTTTTATTACACGGGGAAGCTGCATGTCATGGAGGAGCTGTGCGTATTCTCATTCTGC
CAGGAGATCGAGTACTGGGGCATCAACGAGCTCTTCATTGATTCTTGCTGCAGCAATCGC
TACCAGGAACGCAAGGAGGAAAACCACGAGAAGGACTGGGACCAGAAAAGCCATGATGTG
AGTACCGACTCCTCGTTTGAAGAGTCGTCTCTGTTTGAGAAAGAGCTGGAGAAGTTTGAC
ACACTGCGATTTGGTCAGCTCCGGAAGAAAATCTGGATTAGAATGGAGAATCCAGCGTAC
TGCCTGTCCGCTAAGCTTATCGCTATCTCCTCCTTGAGCGTGGTGCTGGCCTCCATCGTG
GCCATGTGCGTTCACAGCATGTCGGAGTTCCAGAATGAGGATGGAGAAGTGGATGATCCG
GTGCTGGAAGGAGTGGAGATCGCGTGCATTGCCTGGTTCACCGGGGAGCTTGCCGTCCGG
CTGGCTGCCGCTCCTTGTCAAAAGAAATTCTGGAAAAACCCTCTGAACATCATTGACTTT
GTCTCTATTATTCCCTTCTATGCCACGTTGGCTGTAGACACCAAGGAGGAAGAGAGTGAG
GATATTGAGAACATGGGCAAGGTGGTCCAGATCCTACGGCTTATGAGGATTTTCCGAATT
CTAAAGCTTGCCCGGCACTCGGTAGGACTTCGGTCTCTAGGTGCCACACTGAGACACAGC
TACCATGAAGTTGGGCTTCTGCTTCTCTTCCTCTCTGTGGGCATTTCCATTTTCTCTGTG
CTTATCTACTCCGTGGAGAAAGATGACCACACATCCAGCCTCACCAGCATCCCCATCTGC
TGGTGGTGGGCCACCATCAGCATGACAACTGTGGGCTATGGAGACACCCACCCGGTCACC
TTGGCGGGAAAGCTCATCGCCAGCACATGCATCATCTGTGGCATCTTGGTGGTGGCCCTT
CCCATCACCATCATCTTCAACAAGTTTTCCAAGTACTACCAGAAGCAAAAGGACATTGAT
GTGGACCAGTGCAGTGAGGATGCACCAGAGAAGTGTCATGAGCTACCTTACTTTAACATT
AGGGATATATATGCACAGCGGATGCACACCTTCATTACCAGTCTCTCTTCTGTAGGCATT
GTGGTGAGCGATCCTGACTCCACAGATGCTTCAAGCATTGAAGACAATGAGGACATTTGT
AACACCACCTCCTTGGAGAATTGCACAGCAAAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6302
Chromosome Location2
LocusNot Available
References
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