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NameDehydrogenase/reductase SDR family member 4
Synonyms
  • 1.1.1.184
  • CR
  • humNRDR
  • NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
  • NADPH-dependent retinol dehydrogenase/reductase
  • NRDR
  • Peroxisomal short-chain alcohol dehydrogenase
  • PHCR
  • PSCD
  • SCAD-SRL
  • SDR25C2
  • Short chain dehydrogenase/reductase family 25C member 2
  • Short-chain dehydrogenase/reductase family member 4
Gene NameDHRS4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0036939|Dehydrogenase/reductase SDR family member 4
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV
VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN
PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR
RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
Number of residues278
Molecular Weight29536.885
Theoretical pI7.96
GO Classification
Functions
  • 3-keto sterol reductase activity
  • alcohol dehydrogenase [NAD(P)+] activity
  • carbonyl reductase (NADPH) activity
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
  • receptor binding
Processes
  • alcohol metabolic process
  • cellular ketone metabolic process
  • oxidation-reduction process
  • protein tetramerization
  • steroid metabolic process
Components
  • endoplasmic reticulum membrane
  • peroxisome
  • extracellular exosome
  • nuclear membrane
  • intracellular membrane-bounded organelle
  • peroxisomal membrane
  • mitochondrion
  • nucleus
General FunctionReceptor binding
Specific FunctionReduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID4105190
UniProtKB IDQ9BTZ2
UniProtKB Entry NameDHRS4_HUMAN
Cellular LocationPeroxisome
Gene sequence
>lcl|BSEQ0009889|Dehydrogenase/reductase SDR family member 4 (DHRS4)
ATGCACAAGGCGGGGCTGCTAGGCCTCTGTGCCCGGGCTTGGAATTCGGTGCGGATGGCC
AGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACGGCCTCC
ACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCCATGTGGTC
GTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTGCAGGGGGAGGGG
CTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGGACCGGGAGCGGCTGGTG
GCCACGGCTGTGAAGCTTCATGGAGGTATCGATATCCTAGTCTCCAATGCTGCTGTCAAC
CCTTTCTTTGGAAGCATAATGGATGTCACTGAGGAGGTGTGGGACAAGAGGCGGCTCAGT
GGTGATCGTGTCTTCCATAGCAGCCTTCAGTCCATCTCCTCTCTGGATGGACAAGGAAAA
AGAGGAAAGCATGAAAGAAACCCTGCGGATAAGAAGGTTAGGCGAGCCAGAGGATTGTGC
TGGCATCGTGTCTTTCCTGTGCTCTGA
GenBank Gene IDAF044127
GeneCard IDNot Available
GenAtlas IDDHRS4
HGNC IDHGNC:16985
Chromosome Location14
Locus14q11.2
References
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  2. Du J, Huang DY, Liu GF, Wang GL, Xu XL, Wang B, Zhu L: CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. Yi Chuan Xue Bao. 2004 Jul;31(7):661-7. 15473316
  3. Song XH, Liang B, Liu GF, Li R, Xie JP, Du K, Huang DY: Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. Int J Cancer. 2007 Apr 15;120(8):1618-26. 17230527
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