T3DB: Neuronal acetylcholine receptor subunit alpha-10

Name	Neuronal acetylcholine receptor subunit alpha-10
Synonyms	NACHR alpha-10 NACHRA10 Nicotinic acetylcholine receptor subunit alpha-10
Gene Name	CHRNA10
Organism	Human
Amino acid sequence	>lcl\|BSEQ0010285\|Neuronal acetylcholine receptor subunit alpha-10 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK RLARVMDRFFLAIFFSMALVMSLLVLVQAL
Number of residues	450
Molecular Weight	49704.295
Theoretical pI	7.97
GO Classification	Functions receptor binding acetylcholine-activated cation-selective channel activity calcium channel activity Processes synaptic transmission, cholinergic neuromuscular synaptic transmission response to nicotine regulation of membrane potential signal transduction cation transmembrane transport neurological system process detection of mechanical stimulus involved in sensory perception of sound inner ear morphogenesis positive regulation of cytosolic calcium ion concentration regulation of cell proliferation Components neuron projection perikaryon membrane axon postsynaptic membrane acetylcholine-gated channel complex cell junction cytosol synapse
General Function	Receptor binding
Specific Function	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Pfam Domain Function	Neur_chan_LBD (PF02931 ) Neur_chan_memb (PF02932 )
Transmembrane Regions	238-258 268-288 302-322 429-449
GenBank Protein ID	12053839
UniProtKB ID	Q9GZZ6
UniProtKB Entry Name	ACH10_HUMAN
Cellular Location	Cell junction
Gene sequence	>lcl\|BSEQ0010286\|Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10) ATGCCGGCGCGGCGGCGCGTGCTCACCTACGGCTGCTGCTCCGAGCCCTACCCCGACGTC ACCTTCACGCTGCTGCTGCGCCGCCGCGCCGCCGCCTACGTGTGCAACCTGCTGCTGCCC TGCGTGCTCATCTCGCTGCTTGCGCCGCTCGCCTTCCACCTGCCTGCCGACTCAGGCGAG AAGGTGTCGCTGGGCGTCACCGTGCTGCTGGCGCTCACCGTCTTCCAGTTGCTGCTGGCC GAGAGCATGCCACCGGCCGAGAGCGTGCCGCTCATCGGGAAGTACTACATGGCCACTATG ACCATGGTCACATTCTCAACAGCACTCACCATCCTTATCATGAACCTGCATTACTGTGGT CCCAGTGTCCGCCCAGTGCCAGCCTGGGCTAGGGCCCTCCTGCTGGGACACCTGGCACGG GGCCTGTGCGTGCGGGAAAGAGGGGAGCCCTGTGGGCAGTCCAGGCCACCTGAGTTATCT CCTAGCCCCCAGTCGCCTGAAGGAGGGGCTGGCCCCCCAGCGGGCCCTTGCCACGAGCCA CGATGTCTGTGCCGCCAGGAAGCCCTACTGCACCACGTAGCCACCATTGCCAATACCTTC CGCAGCCACCGAGCTGCCCAGCGCTGCCATGAGGACTGGAAGCGCCTGGCCCGTGTGATG GACCGCTTCTTCCTGGCCATCTTCTTCTCCATGGCCCTGGTCATGAGCCTCCTGGTGCTG GTGCAGGCCCTGTGA
GenBank Gene ID	AJ278118
GeneCard ID	Not Available
GenAtlas ID	CHRNA10
HGNC ID	HGNC:13800
Chromosome Location	11
Locus	11p15.5
References	Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, Besnard F: A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol Pharmacol. 2002 Jan;61(1):150-9. 11752216 Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA: Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics. 2001 May 1;73(3):272-83. 11350119 Peng H, Ferris RL, Matthews T, Hiel H, Lopez-Albaitero A, Lustig LR: Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. Life Sci. 2004 Dec 3;76(3):263-80. 15531379