DNA dC->dU-editing enzyme APOBEC-3G

NameDNA dC->dU-editing enzyme APOBEC-3G
Synonyms
  • 3.5.4.-
  • A3G
  • APOBEC-related cytidine deaminase
  • APOBEC-related protein
  • APOBEC-related protein 9
  • ARCD
  • ARP-9
  • CEM-15
  • CEM15
  • Deoxycytidine deaminase
Gene NameAPOBEC3G
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009823|DNA dC->dU-editing enzyme APOBEC-3G
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
YYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRG
FLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFIS
KNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQP
WDGLDEHSQDLSGRLRAILQNQEN
Number of residues384
Molecular Weight46407.605
Theoretical pINot Available
GO Classification
Functions
  • deoxycytidine deaminase activity
  • zinc ion binding
  • RNA binding
  • cytidine deaminase activity
  • protein homodimerization activity
Processes
  • defense response to virus
  • negative regulation of viral genome replication
  • cytidine deamination
  • negative regulation of viral process
  • base conversion or substitution editing
  • DNA cytosine deamination
  • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
  • negative regulation of transposition
  • innate immune response
  • positive regulation of defense response to virus by host
  • viral process
Components
  • cytoplasmic mRNA processing body
  • apolipoprotein B mRNA editing enzyme complex
  • cytoplasm
  • ribonucleoprotein complex
  • cytosol
General FunctionZinc ion binding
Specific FunctionDNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9HC16
UniProtKB Entry NameABC3G_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020909|DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)
ATGAAGCCTCACTTCAGAAACACAGTGGAGCGAATGTATCGAGACACATTCTCCTACAAC
TTTTATAATAGACCCATCCTTTCTCGTCGGAATACCGTCTGGCTGTGCTACGAAGTGAAA
ACAAAGGGTCCCTCAAGGCCCCCTTTGGACGCAAAGATCTTTCGAGGCCAGGTGTATTCC
GAACTTAAGTACCACCCAGAGATGAGATTCTTCCACTGGTTCAGCAAGTGGAGGAAGCTG
CATCGTGACCAGGAGTATGAGGTCACCTGGTACATATCCTGGAGCCCCTGCACAAAGTGT
ACAAGGGATATGGCCACGTTCCTGGCCGAGGACCCGAAGGTTACCCTGACCATCTTTGTT
GCCCGCCTCTACTACTTCTGGGACCCAGATTACCAGGAGGCGCTTCGCAGCCTGTGTCAG
AAAAGAGACGGTCCGCGTGCCACCATGAAGATCATGAATTATGACGAATTTCAGCACTGT
TGGAGCAAGTTCGTGTACAGCCAAAGAGAGCTATTTGAGCCTTGGAATAATCTGCCTAAA
TATTATATATTACTGCACATCATGCTGGGGGAGATTCTCAGACACTCGATGGATCCACCC
ACATTCACTTTCAACTTTAACAATGAACCTTGGGTCAGAGGACGGCATGAGACTTACCTG
TGTTATGAGGTGGAGCGCATGCACAATGACACCTGGGTCCTGCTGAACCAGCGCAGGGGC
TTTCTATGCAACCAGGCTCCACATAAACACGGTTTCCTTGAAGGCCGCCATGCAGAGCTG
TGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGGACCAGGACTACAGGGTTACC
TGCTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCA
AAAAACAAACACGTGAGCCTGTGCATCTTCACTGCCCGCATCTATGATGATCAAGGAAGA
TGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCAAAATTTCAATAATGACATAC
AGTGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCC
TGGGATGGACTAGATGAGCACAGCCAAGACCTGAGTGGGAGGCTGCGGGCCATTCTCCAG
AATCAGGAAAACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17357
Chromosome Location22
LocusNot Available
References
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