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NameNeurexin-3-beta
Synonyms
  • KIAA0743
  • Neurexin III-beta
Gene NameNRXN3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009041|Neurexin-3-beta
MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFH
GSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTT
VKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTR
NGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLN
MAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTA
SIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPT
FRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDE
DFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTA
SSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANP
TEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETR
NYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
Number of residues637
Molecular Weight69304.31
Theoretical pINot Available
GO Classification
Functions
  • neuroligin family protein binding
  • transmembrane signaling receptor activity
  • cell adhesion molecule binding
Processes
  • positive regulation of synapse maturation
  • vocalization behavior
  • neuron cell-cell adhesion
  • signal transduction
  • neurotransmitter secretion
  • angiogenesis
  • learning
  • social behavior
  • adult behavior
  • synapse assembly
  • positive regulation of synapse assembly
Components
  • cell
  • integral component of membrane
General FunctionTransmembrane signaling receptor activity
Specific FunctionNeuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).
Pfam Domain Function
Transmembrane Regions563-583
GenBank Protein IDNot Available
UniProtKB IDQ9HDB5
UniProtKB Entry NameNRX3B_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013580|Neurexin-3-beta (NRXN3)
ATGCACCTGAGAATCCACGCGAGACGGAGCCCTCCTCGCCGGCCGGCCTGGACGCTTGGG
ATCTGGTTCCTGTTCTGGGGATGTATCGTCAGCTCTGTATGGAGTTCTTCTAATGTAGCT
TCCTCCTCCTCCACCTCTTCCTCGCCGGGGTCTCACTCTCAGCACGAGCACCATTTCCAT
GGCAGCAAGCATCACTCAGTGCCTATTTCTATCTATCGTTCCCCTGTTTCCCTTCGAGGA
GGACACGCTGGCGCTACGTACATCTTTGGGAAAAGTGGTGGGCTTATCCTCTACACCTGG
CCAGCCAATGACAGGCCCAGCACGCGGTCTGACCGCCTTGCCGTGGGCTTCAGCACCACT
GTGAAGGATGGCATCTTGGTCCGCATCGACAGTGCTCCAGGACTTGGTGACTTCCTCCAG
CTTCACATAGAACAGGGGAAAATTGGAGTTGTCTTCAACATTGGCACAGTTGACATCTCC
ATCAAAGAGGAGAGAACCCCTGTAAATGACGGCAAATACCATGTGGTACGCTTCACCAGG
AACGGCGGCAACGCCACCCTGCAGGTGGACAACTGGCCAGTGAATGAACATTATCCTACA
GGCAACACTGATAATGAACGCTTCCAAATGGTAAAACAGAAAATCCCCTTCAAATATAAT
CGGCCTGTAGAGGAGTGGCTGCAGGAAAAAGGCCGGCAGTTAACCATCTTCAACACTCAG
GCGCAAATAGCCATTGGTGGAAAGGACAAAGGACGCCTCTTCCAAGGCCAACTCTCTGGG
CTCTATTATGATGGTTTGAAAGTACTGAACATGGCGGCTGAGAACAACCCCAATATTAAA
ATCAATGGAAGTGTTCGGCTGGTTGGAGAAGTCCCATCAATTTTGGGAACAACACAGACG
ACCTCCATGCCACCAGAAATGTCTACTACTGTCATGGAAACCACTACTACAATGGCGACT
ACCACAACCCGTAAGAATCGCTCTACAGCCAGCATTCAGCCAACATCAGATGATCTTGTT
TCATCTGCTGAATGTTCAAGTGATGATGAAGACTTTGTTGAATGTGAGCCGAGTACAGCA
AACCCCACGGAGCCGGGAATCAGACGGGTTCCGGGGGCCTCAGAGGTGATCCGGGAGTCG
AGCAGCACAACAGGGATGGTCGTCGGCATTGTGGCTGCTGCCGCCCTCTGCATCTTGATC
CTCCTGTACGCCATGTACAAGTACAGGAACAGGGACGAGGGGTCCTATCAAGTGGACGAG
ACGCGGAACTACATCAGCAACTCCGCCCAGAGCAACGGCACGCTCATGAAGGAGAAGCAG
CAGAGCTCGAAGAGCGGCCACAAGAAACAGAAAAACAAGGACAGGGAGTATTACGTGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8010
Chromosome Location14
LocusNot Available
References
  1. Occhi G, Rampazzo A, Beffagna G, Antonio Danieli G: Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3). Biochem Biophys Res Commun. 2002 Oct 18;298(1):151-5. 12379233
  2. Rowen L, Young J, Birditt B, Kaur A, Madan A, Philipps DL, Qin S, Minx P, Wilson RK, Hood L, Graveley BR: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. Genomics. 2002 Apr;79(4):587-97. 11944992
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  8. Bot N, Schweizer C, Ben Halima S, Fraering PC: Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases. J Biol Chem. 2011 Jan 28;286(4):2762-73. doi: 10.1074/jbc.M110.142521. Epub 2010 Nov 17. 21084300