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NamePotassium voltage-gated channel subfamily D member 1
Synonyms
  • Voltage-gated potassium channel subunit Kv4.1
Gene NameKCND1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008577|Potassium voltage-gated channel subfamily D member 1
MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR
YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF
YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPH
TSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVL
IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVF
RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIP
AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR
ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHH
LLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRR
AIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIIS
IPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL
Number of residues647
Molecular Weight71329.6
Theoretical pINot Available
GO Classification
Functions
  • delayed rectifier potassium channel activity
  • metal ion binding
Processes
  • protein homooligomerization
  • synaptic transmission
  • potassium ion transmembrane transport
Components
  • neuronal cell body
  • plasma membrane
  • voltage-gated potassium channel complex
  • integral component of membrane
  • dendrite
General FunctionMetal ion binding
Specific FunctionPore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Pfam Domain Function
Transmembrane Regions185-205 227-247 262-282 292-312 326-346 387-407
GenBank Protein IDNot Available
UniProtKB IDQ9NSA2
UniProtKB Entry NameKCND1_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0020801|Potassium voltage-gated channel subfamily D member 1 (KCND1)
ATGGCGGCAGGCCTGGCCACGTGGCTGCCTTTTGCTCGGGCAGCAGCAGTGGGCTGGCTG
CCCCTGGCCCAGCAACCCCTGCCCCCGGCACCGGGGGTGAAGGCATCTCGAGGAGATGAG
GTTCTGGTGGTGAACGTGAGCGGACGGCGCTTTGAGACTTGGAAGAATACGCTGGACCGC
TACCCAGACACCTTGCTGGGCAGCTCGGAGAAGGAATTCTTCTACGATGCTGACTCAGGC
GAGTACTTCTTCGATCGCGACCCTGACATGTTCCGCCATGTGCTGAACTTCTACCGAACG
GGGCGGCTGCATTGCCCACGGCAGGAGTGCATCCAGGCCTTCGACGAAGAGCTGGCTTTC
TACGGCCTGGTTCCCGAGCTAGTCGGTGACTGCTGCCTTGAAGAGTATCGGGACCGAAAG
AAGGAGAATGCCGAGCGCCTGGCAGAGGATGAGGAGGCAGAGCAGGCCGGGGACGGCCCA
GCCCTGCCAGCAGGCAGCTCCCTGCGGCAGCGGCTCTGGCGGGCCTTCGAGAATCCACAC
ACGAGCACCGCAGCCCTCGTTTTCTACTATGTGACCGGCTTCTTCATCGCCGTGTCGGTC
ATCGCCAATGTGGTGGAGACCATCCCATGCCGCGGCTCTGCACGCAGGTCCTCAAGGGAG
CAGCCCTGTGGCGAACGCTTCCCACAGGCCTTTTTCTGCATGGACACAGCCTGTGTACTC
ATATTCACAGGTGAATACCTCCTGCGGCTGTTTGCCGCCCCCAGCCGTTGCCGCTTCCTG
CGGAGTGTCATGAGCCTCATCGACGTGGTGGCCATCCTGCCCTACTACATTGGGCTTTTG
GTGCCCAAGAACGACGATGTCTCTGGCGCCTTTGTCACCCTGCGTGTGTTCCGGGTGTTT
CGCATCTTCAAGTTCTCCAGGCACTCACAGGGCTTGAGGATTCTGGGCTACACACTCAAG
AGCTGTGCCTCTGAGCTGGGCTTTCTCCTCTTTTCCCTAACCATGGCCATCATCATCTTT
GCCACTGTCATGTTTTATGCTGAGAAGGGCACAAACAAGACCAACTTTACAAGCATCCCT
GCGGCCTTCTGGTATACCATTGTCACCATGACCACGCTTGGCTACGGAGACATGGTGCCC
AGCACCATTGCTGGCAAGATTTTCGGGTCCATCTGCTCACTCAGTGGCGTCTTGGTCATT
GCCCTGCCTGTGCCAGTCATTGTGTCCAACTTTAGCCGCATCTACCACCAGAACCAGCGG
GCTGACAAGCGCCGAGCACAGCAGAAGGTGCGCTTGGCAAGGATCCGATTGGCAAAGAGT
GGTACCACCAATGCCTTCCTGCAGTACAAGCAGAATGGGGGCCTTGAGGACAGCGGCAGT
GGCGAGGAACAGGCTCTTTGTGTCAGGAACCGTTCTGCCTTTGAACAGCAACATCACCAC
TTGCTGCACTGTCTAGAGAAGACAACGTGCCATGAGTTCACAGATGAGCTCACCTTCAGT
GAAGCCCTGGGAGCCGTCTCGCCGGGTGGCCGCACCAGCCGTAGCACCTCTGTGTCTTCC
CAGCCAGTGGGACCCGGAAGCCTGCTGTCTTCTTGCTGCCCTCGCAGGGCCAAGCGCCGC
GCCATCCGCCTTGCCAACTCCACTGCCTCAGTCAGCCGTGGCAGCATGCAGGAGCTGGAC
ATGCTGGCAGGGCTGCGCAGGAGCCATGCCCCTCAGAGCCGTTCCAGCCTCAATGCCAAG
CCCCATGACAGCCTTGACCTGAACTGCGACAGCCGGGACTTCGTGGCTGCCATTATCAGC
ATCCCTACCCCTCCTGCCAACACCCCAGATGAGAGCCAACCTTCCTCCCCTGGCGGCGGT
GGCAGGGCCGGCAGCACCCTCAGGAACTCCAGCCTGGGTACCCCTTGCCTCTTCCCCGAG
ACTGTCAAGATCTCATCCCTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6237
Chromosome LocationX
LocusNot Available
References
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