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NameNAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms
  • 3.5.1.-
  • hSIRT3
  • Regulatory protein SIR2 homolog 3
  • SIR2-like protein 3
  • SIR2L3
Gene NameSIRT3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009468|NAD-dependent protein deacetylase sirtuin-3, mitochondrial
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Number of residues399
Molecular Weight43572.71
Theoretical pINot Available
GO Classification
Functions
  • zinc ion binding
  • NAD+ ADP-ribosyltransferase activity
  • NAD+ binding
  • hydrolase activity
Processes
  • aerobic respiration
  • organelle organization
  • mitochondrion organization
  • aging
  • positive regulation of insulin secretion
  • negative regulation of ERK1 and ERK2 cascade
  • protein deacetylation
  • protein ADP-ribosylation
  • negative regulation of reactive oxygen species metabolic process
  • peptidyl-lysine deacetylation
Components
  • mitochondrion
  • mitochondrial matrix
General FunctionZinc ion binding
Specific FunctionNAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9NTG7
UniProtKB Entry NameSIR3_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0017468|NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
ATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATTCCAGACTTCAGATCGCCGGGGAGT
GGCCTGTACAGCAACCTCCAGCAGTACGATCTCCCGTACCCCGAGGCCATTTTTGAACTC
CCATTCTTCTTTCACAACCCCAAGCCCTTTTTCACTTTGGCCAAGGAGCTGTACCCTGGA
AACTACAAGCCCAACGTCACTCACTACTTTCTCCGGCTGCTTCATGACAAGGGGCTGCTT
CTGCGGCTCTACACGCAGAACATCGATGGGCTTGAGAGAGTGTCGGGCATCCCTGCCTCA
AAGCTGGTTGAAGCTCATGGAACCTTTGCCTCTGCCACCTGCACAGTCTGCCAAAGACCC
TTCCCAGGGGAGGACATTCGGGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTC
TGCACCGGCGTTGTGAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTC
TTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGCTCATCCTTGGGACCTCCCTG
GAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTC
ATCAACCGGGACTTGGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAG
CTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGCTTCTGGGCTGGACAGAAGAG
ATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:14931
Chromosome Location11
LocusNot Available
References
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