NameChloride intracellular channel protein 5
SynonymsNot Available
Gene NameCLIC5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009050|Chloride intracellular channel protein 5
MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVS
VYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLC
AAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVK
AGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDV
KTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGL
TKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKK
YRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS
Number of residues410
Molecular Weight46502.195
Theoretical pINot Available
GO Classification
Functions
  • voltage-gated ion channel activity
  • chloride channel activity
Processes
  • neuromuscular process controlling balance
  • protein localization
  • diet induced thermogenesis
  • transport
  • auditory receptor cell stereocilium organization
  • chloride transport
  • sensory perception of sound
  • female pregnancy
  • chloride transmembrane transport
Components
  • microtubule organizing center
  • chloride channel complex
  • cell cortex
  • stereocilium
  • actin cytoskeleton
  • Golgi apparatus
  • extracellular exosome
General FunctionVoltage-gated ion channel activity
Specific FunctionRequired for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).
Pfam Domain Function
Transmembrane Regions193-213
GenBank Protein IDNot Available
UniProtKB IDQ9NZA1
UniProtKB Entry NameCLIC5_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020848|Chloride intracellular channel protein 5 (CLIC5)
ATGAATGACGAAGACTACAGCACCATCTATGACACAATCCAAAATGAGAGGACGTATGAG
GTTCCAGACCAGCCAGAAGAAAATGAAAGTCCCCATTATGATGATGTCCATGAGTACTTA
AGGCCAGAAAATGATTTATATGCCACTCAGCTGAATACCCATGAGTATGATTTTGTGTCA
GTCTATACCATTAAGGGTGAAGAGACCAGCTTGGCCTCTGTCCAGTCAGAAGACAGAGGC
TACCTCCTGCCTGATGAGATATACTCTGAACTCCAGGAGGCTCATCCAGGTGAGCCCCAG
GAGGACAGGGGCATCTCAATGGAAGGGTTATATTCATCAACCCAGGACCAGCAACTCTGC
GCAGCAGAACTCCAGGAGAATGGGAGTGTGATGAAGGAAGATCTGCCTTCTCCTTCAAGC
TTCACCATTCAGCACAGTAAGGCCTTCTCTACCACCAAGTATTCCTGCTATTCTGATGCT
GAAGGTTTGGAAGAAAAGGAGGGAGCTCACATGAACCCTGAGATTTACCTCTTTGTGAAG
GCTGGAATCGATGGAGAAAGCATCGGCAACTGTCCTTTCTCTCAGCGCCTCTTCATGATC
CTCTGGCTGAAAGGAGTCGTGTTCAATGTCACCACTGTGGATCTGAAAAGAAAGCCAGCT
GACCTGCACAACCTAGCCCCCGGCACGCACCCGCCCTTCCTGACCTTCAACGGGGACGTG
AAGACAGACGTCAATAAGATCGAGGAGTTCCTGGAGGAGACCTTGACCCCTGAAAAGTAC
CCCAAACTGGCTGCAAAACACCGGGAATCCAACACAGCGGGCATCGACATCTTTTCCAAG
TTTTCTGCCTACATCAAAAATACCAAGCAGCAGAACAATGCTGCTCTTGAAAGAGGCCTA
ACCAAGGCTCTAAAGAAATTGGATGACTACCTGAACACCCCTCTACCAGAGGAGATTGAC
GCCAACACTTGTGGGGAAGACAAGGGGTCCCGGCGCAAGTTCCTGGATGGGGATGAGCTG
ACCCTGGCTGACTGCAATCTGTTGCCCAAGCTCCATGTGGTCAAGATTGTGGCCAAGAAA
TACCGCAACTATGATATCCCGGCTGAGATGACAGGCCTGTGGCGGTACCTCAAGAACGCC
TATGCCCGTGATGAGTTCACCAACACCTGTGCAGCTGACAGTGAGATCGAGTTGGCCTAC
GCTGATGTCGCCAAACGCCTCAGCCGATCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13517
Chromosome Location6
LocusNot Available
References
  1. Berryman M, Bretscher A: Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol Biol Cell. 2000 May;11(5):1509-21. 10793131
  2. Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR: AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J Biol Chem. 2002 Oct 25;277(43):40973-80. Epub 2002 Aug 5. 12163479
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  8. Singh H, Cousin MA, Ashley RH: Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin. FEBS J. 2007 Dec;274(24):6306-16. Epub 2007 Nov 19. 18028448
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