Short transient receptor potential channel 4

NameShort transient receptor potential channel 4
Synonyms
  • hTrp-4
  • hTrp4
  • Trp-related protein 4
  • TrpC4
Gene NameTRPC4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008885|Short transient receptor potential channel 4
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA
MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
SDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVT
DIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIP
GLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYD
LNLPDTVTHEDYVTTRL
Number of residues977
Molecular Weight112099.88
Theoretical pINot Available
GO Classification
Functions
  • cadherin binding
  • inositol 1,4,5 trisphosphate binding
  • beta-catenin binding
  • store-operated calcium channel activity
Processes
  • calcium ion transmembrane transport
  • regulation of calcium ion transport
  • calcium ion import
  • gamma-aminobutyric acid secretion
  • oligodendrocyte differentiation
  • calcium ion transport
  • axon guidance
  • manganese ion transport
  • transmembrane transport
  • ion transmembrane transport
  • cytosolic calcium ion homeostasis
Components
  • caveola
  • plasma membrane
  • cortical cytoskeleton
  • cell surface
  • cytosol
  • calcium channel complex
  • integral component of plasma membrane
  • basolateral plasma membrane
General FunctionStore-operated calcium channel activity
Specific FunctionForm a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Pfam Domain FunctionNot Available
Transmembrane Regions330-350 363-383 437-457 470-490 512-532 600-620
GenBank Protein IDNot Available
UniProtKB IDQ9UBN4
UniProtKB Entry NameTRPC4_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013474|Short transient receptor potential channel 4 (TRPC4)
ATGGCTCAGTTCTATTACAAAAGAAATGTTAATGCTCCCTATAGAGACCGCATCCCTCTA
AGGATAGTAAGAGCAGAATCAGAACTCTCGCCATCAGAAAAAGCCTACTTGAATGCTGTG
GAAAAGGGAGATTATGCCAGTGTCAAGAAATCCCTAGAGGAAGCTGAAATTTATTTTAAA
ATCAATATTAATTGCATTGATCCTCTCGGAAGAACTGCTCTCCTCATTGCAATTGAAAAT
GAGAACTTGGAGCTCATCGAACTACTCTTAAGCTTTAATGTCTATGTTGGAGATGCTCTA
TTACATGCTATCAGAAAAGAAGTCGTCGGAGCTGTTGAGCTGTTATTGAACCACAAAAAA
CCTAGTGGAGAAAAACAGGTGCCTCCTATACTCCTTGATAAGCAGTTCTCTGAATTCACT
CCAGACATTACACCAATCATTTTGGCAGCCCATACAAATAATTATGAGATAATAAAACTC
TTGGTTCAGAAAGGAGTCTCAGTGCCTCGACCCCACGAGGTCCGCTGTAACTGTGTGGAA
TGCGTGTCCAGTTCAGATGTGGACAGCCTCCGTCACTCACGCTCCAGACTCAACATCTAC
AAGGCCTTGGCCAGTCCCTCTCTCATTGCACTGTCAAGCGAAGATCCTTTTCTCACAGCC
TTTCAGTTAAGTTGGGAACTTCAGGAACTGAGCAAGGTGGAAAATGAATTCAAGTCGGAG
TATGAAGAGCTGTCACGGCAGTGCAAACAATTTGCTAAGGACCTACTGGATCAGACGAGA
AGTTCCAGAGAACTGGAAATCATTCTTAATTACCGAGATGACAATAGTCTCATAGAAGAA
CAAAGTGGAAATGATCTTGCAAGACTAAAATTGGCCATTAAGTACCGTCAAAAAGAGTTT
GTTGCCCAGCCCAATTGTCAACAGCTGCTGGCATCTCGCTGGTACGATGAGTTTCCAGGC
TGGAGGAGAAGACACTGGGCAGTGAAGATGGTGACATGTTTCATAATAGGACTTCTTTTT
CCTGTCTTCTCTGTGTGCTACCTGATAGCTCCCAAAAGCCCACTTGGACTGTTCATCAGG
AAGCCATTTATCAAGTTTATCTGCCACACAGCCTCCTATTTGACTTTTTTGTTCCTGCTG
CTGCTTGCCTCTCAGCACATCGACAGGTCAGACTTGAACAGGCAAGGTCCACCACCAACC
ATCGTCGAGTGGATGATATTACCGTGGGTCCTGGGCTTCATATGGGGAGAAATTAAACAG
ATGTGGGATGGCGGACTTCAGGACTACATCCATGATTGGTGGAATCTAATGGACTTTGTA
ATGAACTCCTTATATTTAGCAACAATCTCCTTGAAAATTGTTGCATTTGTAAAGTACAGT
GCCCTTAATCCACGAGAATCATGGGACATGTGGCATCCCACTCTGGTGGCAGAGGCTTTA
TTTGCTATTGCAAACATCTTCAGTTCTCTGCGTCTGATCTCACTGTTTACTGCAAATTCT
CACCTGGGACCTCTGCAAATATCTCTGGGAAGAATGCTCCTGGACATTTTGAAGTTTCTA
TTCATATACTGCCTTGTGTTGCTAGCATTTGCAAATGGCCTAAATCAATTGTACTTCTAT
TATGAAGAAACGAAAGGGTTAACCTGCAAAGGCATAAGATGTGAAAAGCAGAATAATGCA
TTTTCAACGTTATTTGAGACACTGCAGTCCCTGTTTTGGTCAATATTTGGGCTCATCAAT
TTATATGTGACCAATGTCAAAGCACAGCATGAATTTACTGAGTTTGTTGGTGCCACCATG
TTTGGGACATACAATGTCATCTCTCTGGTTGTTCTACTCAACATGTTAATAGCTATGATG
AATAATTCTTACCAACTGATTGCTGACCATGCAGATATAGAATGGAAATTTGCACGAACA
AAGCTTTGGATGAGTTATTTTGAAGAAGGAGGTACTCTGCCTACTCCCTTCAATGTCATC
CCGAGCCCCAAGTCTCTCTGGTACCTGATCAAATGGATCTGGACACACTTGTGCAAGAAA
AAGATGAGAAGAAAGCCAGAAAGTTTTGGAACAATAGGGAGGCGAGCTGCTGATAACTTG
AGAAGACATCACCAATACCAAGAAGTTATGAGGAACCTGGTGAAGCGATACGTTGCTGCA
ATGATTAGAGATGCTAAAACTGAAGAAGGCCTGACCGAAGAGAACTTTAAGGAACTAAAG
CAAGACATTTCTAGTTTCCGCTTTGAAGTCCTGGGATTACTAAGAGGAAGCAAACTTTCC
ACAATACAATCTGCGAATGCCTCGAAGGAGTCTTCAAATTCGGCAGACTCAGATGAAAAG
AGTGATAGCGAAGAAGAAGTTGCTCGTCAACAGGCTGCAGGACCACTTGAGAGAAATATT
CAACTGGAATCTCGAGGATTAGCTTCACGGGGTGACCTGAGCATTCCCGGTCTCAGTGAA
CAATGTGTGTTAGTAGACCATAGAGAAAGGAATACGGACACACTGGGGTTACAGGTAGGA
AAGAGAGTGTGTCCATTCAAGTCAGAGAAGGTGGTGGTGGAGGACACGGTTCCTATAATA
CCAAAGGAGAAACATGCAAAAGAAGAGGACTCTAGTATAGACTATGATCTAAACCTCCCA
GACACAGTCACCCACGAAGATTACGTGACCACAAGATTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12336
Chromosome Location13
LocusNot Available
References
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