NameChymotrypsin-like elastase family member 1
Synonyms
  • 3.4.21.36
  • ELA1
  • Elastase-1
  • Pancreatic elastase 1
Gene NameCELA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007212|Chymotrypsin-like elastase family member 1
MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMT
AAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQS
VTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSS
YWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTV
FTQVSAYISWINNVIASN
Number of residues258
Molecular Weight27797.995
Theoretical pI8.38
GO Classification
Functions
  • serine-type endopeptidase activity
  • metal ion binding
Processes
  • regulation of cell proliferation
  • multicellular organism growth
  • post-embryonic development
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of transcription from RNA polymerase II promoter
  • Wnt signaling pathway
  • exocrine pancreas development
  • pancreas morphogenesis
  • proteolysis
  • inflammatory response
  • regulation of cell differentiation
Components
  • extracellular space
General FunctionSerine-type endopeptidase activity
Specific FunctionActs upon elastin.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID4731318
UniProtKB IDQ9UNI1
UniProtKB Entry NameCELA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020715|Chymotrypsin-like elastase family member 1 (CELA1)
ATGCTGGTCCTTTATGGACACAGCACCCAGGACCTTCCGGAAACCAATGCCCGCGTAGTC
GGAGGGACTGAGGCCGGGAGGAATTCCTGGCCCTCTCAGATTTCCCTCCAGTACCGGTCT
GGAGGTTCCCGGTATCACACCTGTGGAGGGACCCTTATCAGACAGAACTGGGTGATGACA
GCTGCTCACTGCGTGGATTACCAGAAGACTTTCCGCGTGGTGGCTGGAGACCATAACCTG
AGCCAGAATGATGGCACTGAGCAGTACGTGAGTGTGCAGAAGATCGTGGTGCATCCATAC
TGGAACAGCGATAACGTGGCTGCCGGCTATGACATCGCCCTGCTGCGCCTGGCCCAGAGC
GTTACCCTCAATAGCTATGTCCAGCTGGGTGTTCTGCCCCAGGAGGGAGCCATCCTGGCT
AACAACAGTCCCTGCTACATCACAGGCTGGGGCAAGACCAAGACCAATGGGCAGCTGGCC
CAGACCCTGCAGCAGGCTTACCTGCCCTCTGTGGACTACGCCATCTGCTCCAGCTCCTCC
TACTGGGGCTCCACTGTGAAGAACACCATGGTGTGTGCTGGTGGAGATGGAGTTCGCTCT
GGATGCCAGGGTGACTCTGGGGGCCCCCTCCATTGCTTGGTGAATGGCAAGTATTCTGTC
CATGGAGTGACCAGCTTTGTGTCCAGCCGGGGCTGTAATGTCTCCAGGAAGCCTACAGTC
TTCACCCAGGTCTCTGCTTACATCTCCTGGATAAATAATGTCATCGCCTCCAACTGA
GenBank Gene IDAF120493
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3308
Chromosome Location12
Locus12q13
References
  1. Talas U, Dunlop J, Khalaf S, Leigh IM, Kelsell DP: Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism. J Invest Dermatol. 2000 Jan;114(1):165-70. 10620133
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