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NameGroup IID secretory phospholipase A2
Synonyms
  • 3.1.1.4
  • GIID sPLA2
  • Phosphatidylcholine 2-acylhydrolase 2D
  • PLA2IID
  • Secretory-type PLA, stroma-associated homolog
  • SPLASH
Gene NamePLA2G2D
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012800|Group IID secretory phospholipase A2
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDAT
DWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLK
RNLDTYQKRLRFYWRPHCRGQTPGC
Number of residues145
Molecular Weight16546.1
Theoretical pI8.28
GO Classification
Functions
  • calcium ion binding
  • phospholipase A2 activity
  • heparin binding
Processes
  • phosphatidic acid biosynthetic process
  • phosphatidylcholine acyl-chain remodeling
  • phosphatidylethanolamine acyl-chain remodeling
  • phosphatidylglycerol acyl-chain remodeling
  • phosphatidylinositol acyl-chain remodeling
  • phosphatidylserine acyl-chain remodeling
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
  • inflammatory response
  • small molecule metabolic process
  • negative regulation of T cell proliferation
  • glycerophospholipid biosynthetic process
  • phospholipid metabolic process
  • lipid catabolic process
Components
  • extracellular region
General FunctionPhospholipase a2 activity
Specific FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID5771420
UniProtKB IDQ9UNK4
UniProtKB Entry NamePA2GD_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0012801|Group IID secretory phospholipase A2 (PLA2G2D)
ATGGAACTTGCACTGCTGTGTGGGCTGGTGGTGATGGCTGGTGTGATTCCAATCCAGGGC
GGGATCCTGAACCTGAACAAGATGGTCAAGCAAGTGACTGGGAAAATGCCCATCCTCTCC
TACTGGCCCTACGGCTGTCACTGCGGACTAGGTGGCAGAGGCCAACCCAAAGATGCCACG
GACTGCTGA
GenBank Gene IDAF112982
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9033
Chromosome Location1
Locus1p36.12
References
  1. Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K: Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem. 1999 Aug 27;274(35):24973-9. 10455175
  2. Shakhov AN, Rubtsov AV, Lyakhov IG, Tumanov AV, Nedospasov SA: SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. Genes Immun. 2000 Feb;1(3):191-9. 11196711
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