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NameC-C motif chemokine 26
Synonyms
  • CC chemokine IMAC
  • Eotaxin-3
  • Macrophage inflammatory protein 4-alpha
  • MIP-4-alpha
  • SCYA26
  • Small-inducible cytokine A26
  • Thymic stroma chemokine-1
  • TSC-1
Gene NameCCL26
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019739|C-C motif chemokine 26
MMGLSLASAVLLASLLSLHLGTATRGSDISKTCCFQYSHKPLPWTWVRSYEFTSNSCSQR
AVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL
Number of residues94
Molecular Weight10647.495
Theoretical pINot Available
GO Classification
Functions
  • chemokine activity
  • CCR chemokine receptor binding
Processes
  • signal transduction
  • chemokine-mediated signaling pathway
  • immune response
  • cellular response to interleukin-1
  • cellular response to interferon-gamma
  • eosinophil chemotaxis
  • inflammatory response
  • lymphocyte chemotaxis
  • cell-cell signaling
  • chemotaxis
  • cellular response to tumor necrosis factor
  • positive regulation of cell migration
  • G-protein coupled receptor signaling pathway
  • neutrophil chemotaxis
  • positive regulation of GTPase activity
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of endothelial cell proliferation
  • positive regulation of actin filament polymerization
  • monocyte chemotaxis
Components
  • extracellular space
General FunctionChemokine activity
Specific FunctionChemotactic for eosinophils and basophils. Binds to CCR3.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9Y258
UniProtKB Entry NameCCL26_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0019740|C-C motif chemokine 26 (CCL26)
ATGATGGGCCTCTCCTTGGCCTCTGCTGTGCTCCTGGCCTCCCTCCTGAGTCTCCACCTT
GGAACTGCCACACGTGGGAGTGACATATCCAAGACCTGCTGCTTCCAATACAGCCACAAG
CCCCTTCCCTGGACCTGGGTGCGAAGCTATGAATTCACCAGTAACAGCTGCTCCCAGCGG
GCTGTGATATTCACTACCAAAAGAGGCAAGAAAGTCTGTACCCATCCAAGGAAAAAATGG
GTGCAAAAATACATTTCTTTACTGAAAACTCCGAAACAATTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10625
Chromosome Location7
LocusNot Available
References
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  2. Shinkai A, Yoshisue H, Koike M, Shoji E, Nakagawa S, Saito A, Takeda T, Imabeppu S, Kato Y, Hanai N, Anazawa H, Kuga T, Nishi T: A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 1999 Aug 1;163(3):1602-10. 10415065
  3. Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, Hirai K, Nomiyama H, Yoshie O: Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem. 1999 Sep 24;274(39):27975-80. 10488147
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