NameEpididymis-specific alpha-mannosidase
Synonyms
  • 3.2.1.24
  • KIAA0935
  • Mannosidase alpha class 2B member 2
Gene NameMAN2B2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009607|Epididymis-specific alpha-mannosidase
MGQLCWLPLLAPLLLLRPPGVQSAGPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSV
VEELARGQQRRFIAVEQEFFRLWWDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVT
HLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFALAGFNAHLGSRIDYDL
KAAMQEARGLQFVWRGSPSLSERQEIFTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPK
PPQDGVYPNMSEPVTPANINLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFA
NMDPLLDHINSHAAELGVSVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTG
FYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHH
DAITGTESPKVRDMYATHLASGMLGMRKLMASIVLDELQPQAPMAASSDAGPAGHFASVY
NPLAWTVTTIVTLTVGFPGVRVTDEAGHPVPSQIQNSTETPSAYDLLILTTIPGLSYRHY
NIRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHAGRYLVPVANDCYIVLLDQDTNLMH
SIWERQSNRTVRVTQEFLEYHVNGDVKQGPISDNYLFTPGKAAVPAWEAVEMEIVAGQLV
TEIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIEQEYQAGPLELNREAVLRTS
TNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVLLSERAHG
ISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTSVVHPVLWLLLGSWSLTTALRQRSAL
ALQHRPVVLFGDLAGTAPKLPGPQQQEAVTLPPNLHLQILSIPGWRYSSNHTEHSQNLRK
GHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWD
LSMLHRWSWRTGPGRHRGDTTSPSRPPGGPIITVHPKEIRTFFIHFQQQ
Number of residues1009
Molecular Weight113978.29
Theoretical pINot Available
GO Classification
Functions
  • alpha-mannosidase activity
  • zinc ion binding
  • carbohydrate binding
Processes
  • protein deglycosylation
  • mannose metabolic process
Components
  • extracellular exosome
  • vacuolar membrane
General FunctionZinc ion binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9Y2E5
UniProtKB Entry NameMA2B2_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0013666|Epididymis-specific alpha-mannosidase (MAN2B2)
ATGGGGCAGCTGTGCTGGCTGCCGCTGCTGGCACCGCTCCTGTTGCTGCGACCGCCAGGG
GTCCAGTCCGCCGGCCCCATCCGGGCCTTCGTGGTGCCCCACAGCCACATGGACGTGGGC
TGGGTCTACACTGTGCAGGAAAGCATGCGGGCGTACGCCGCCAATGTCTACACCTCAGTG
GTGGAAGAGCTGGCCCGCGGCCAGCAGCGCCGGTTCATCGCTGTGGAGCAGGAGTTTTTC
CGGCTGTGGTGGGATGGCGTCGCCTCGGACCAGCAGAAATACCAGGTCCGCCAGCTCCTG
GAGGAAGGACGCCTGGAATTTGTCATCGGAGGCCAGGTCATGCATGACGAGGCTGTGACG
CACCTTGATGACCAGATCCTGCAGCTCACAGAAGGACACGGGTTTCTCTATGAAACATTT
GGGATCCGGCCACAGTTCTCCTGGCACGTTGACCCGTTTGGCGCCTCTGCCACGACGCCC
ACCCTATTTGCGCTGGCGGGCTTCAATGCCCACCTCGGCTCCCGGATCGACTACGACCTG
AAGGCAGCCATGCAGGAGGCCCGGGGGCTGCAGTTCGTGTGGCGAGGGTCCCCATCCCTC
TCAGAGCGGCAGGAAATCTTCACGCACATCATGGACCAGTACAGCTACTGCACCCCGTCC
CACATCCCTTTCTCCAACAGGTCAGGATTTTACTGGAATGGCGTGGCTGTCTTCCCCAAG
CCTCCCCAAGATGGGGTGTACCCCAACATGAGTGAGCCTGTCACCCCAGCCAACATCAAC
CTCTATGCCGAGCTCGGTGTCTCGGTGCAGTATGCCACGCTGGGCGACTACTTCCGTGCC
CTGCACGCTCTCAATGTCACCTGGCGTGTCCGCGACCACCACGACTTCCTGCCCTATTCC
ACAGAACCATTCCAGGCCTGGACGGGCTTCTACACGTCCCGCAGCTCACTGAAGGGGCTG
GCCCGGCGAGCCAGCGCCTTGTTGTATGCCGGGGAGTCCATGTTCACACGCTACCTGTGG
CCGGCCCCCCGTGGGCATCTGGACCCCACCTGGGCCCTGCAGCAGCTCCAGCAGCTTCGC
TGGGCCGTCTCCGAGGTCCAGCACCATGATGCCATCACTGGGACTGAGTCCCCCAAGGTG
AGAGACATGTACGCAACGCACCTGGCCTCGGGGATGCTGGGCATGCGCAAGCTGATGGCC
TCCATCGTCCTAGATGAGCTCCAGCCCCAGGCACCCATGGCGGCCAGCTCCGATGCAGGA
CCTGCAGGACATTTTGCCTCGGTCTACAACCCGCTGGCCTGGACGGTCACCACCATCGTC
ACCCTGACTGTTGGTTTCCCTGGAGTCCGCGTCACAGATGAGGCGGGCCACCCAGTGCCC
TCGCAGATCCAGAACTCAACAGAGACCCCATCTGCGTATGACCTGCTTATTCTGACCACA
ATCCCAGGCCTCAGTTACCGGCACTACAACATCAGACCCACTGCAGGGGCCCAAGAGGGC
ACCCAGGAGCCGGCTGCCACTGTGGCGAGCACCCTTCAATTTGGCCGCAGGCTGAGGAGA
CGCACCAGCCATGCGGGCAGGTACTTGGTGCCTGTGGCAAACGACTGCTACATTGTGCTG
CTCGACCAGGATACCAACCTGATGCACAGCATCTGGGAGAGACAGAGTAACCGAACGGTG
CGCGTGACCCAGGAATTCCTGGAGTACCACGTCAACGGGGATGTGAAACAGGGCCCCATT
TCCGATAACTACCTGTTCACACCGGGCAAGGCCGCGGTGCCTGCGTGGGAAGCTGTGGAA
ATGGAGATTGTGGCGGGACAGCTTGTGACTGAGATCCGGCAGTACTTCTACAGGAACATG
ACAGCACAGAATTACACGTATGCAATCCGCTCCCGGCTCACCCATGTGCCGCAGGGCCAT
GACGGGGAGCTGCTCTGCCACCGGATAGAGCAGGAGTACCAAGCCGGCCCCCTGGAGCTG
AACCGTGAGGCTGTCCTGAGGACCAGCACCAACCTAAACAGCCAGCAGGTCATCTACTCA
GACAACAACGGCTACCAGATGCAGCGGAGGCCCTACGTTTCCTATGTGAACAACAGCATC
GCCCGGAATTACTACCCCATGGTTCAGTCGGCCTTCATGGAGGATGGCAAAAGCAGGCTT
GTGTTGCTGTCGGAGCGGGCACATGGCATCTCCAGCCAAGGGAATGGGCAGGTGGAGGTC
ATGCTCCACCGGCGGCTGTGGAACAACTTCGACTGGGACCTGGGCTACAACCTCACGCTG
AACGACACCTCAGTCGTCCACCCAGTGCTCTGGCTTCTGCTGGGATCCTGGTCCCTCACC
ACTGCCCTGCGCCAGAGGAGCGCACTGGCGCTGCAGCACAGGCCCGTGGTGCTGTTCGGA
GACCTCGCTGGGACTGCGCCGAAGCTCCCAGGACCCCAGCAGCAAGAGGCCGTGACGCTG
CCCCCGAATCTTCACCTGCAGATCCTGAGCATCCCTGGCTGGCGCTACAGCTCCAACCAC
ACGGAGCACTCTCAGAATCTCCGGAAAGGCCATCGAGGGGAAGCCCAGGCTGACCTCCGC
CGTGTCCTGCTGCGGCTCTACCACCTGTATGAAGTGGGCGAGGACCCAGTCCTGTCTCAG
CCAGTGACAGTGAATCTGGAGGCTGTGCTGCAGGCGCTGGGGTCCGTGGTGGCAGTGGAG
GAGCGCTCGCTCACAGGGACCTGGGATTTGAGCATGCTGCACCGCTGGAGCTGGAGGACG
GGGCCTGGCCGCCACAGAGGTGACACCACCTCTCCCTCGAGGCCACCAGGAGGCCCCATC
ATCACCGTCCACCCAAAGGAAATCCGGACGTTCTTTATTCACTTTCAACAGCAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:29623
Chromosome Location4
LocusNot Available
References
  1. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. 17974005
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. 15815621
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Feb 26;6(1):63-70. 10231032
  5. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. 19159218