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Adenylate kinase isoenzyme 6

NameAdenylate kinase isoenzyme 6
Synonyms
  • 2.7.4.3
  • Adrenal gland protein AD-004
  • AK/ATPase
  • AK6
  • CINAP
  • Coilin-interacting nuclear ATPase protein
  • Dual activity adenylate kinase/ATPase
  • hCINAP
Gene NameAK6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008946|Adenylate kinase isoenzyme 6
MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDR
VVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNI
QCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS
Number of residues172
Molecular Weight20061.315
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • ATPase activity
  • adenylate kinase activity
Processes
  • nucleotide phosphorylation
Components
  • membrane
  • nucleoplasm
  • Cajal body
General FunctionAtpase activity
Specific FunctionBroad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9Y3D8
UniProtKB Entry NameKAD6_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013523|Adenylate kinase isoenzyme 6 (AK6)
ATGTGTCATCGAAAGCCAGGTACACCAGGGGTTGGAAAAACCACACTAGGCAAAGAACTT
GCGTCAAAATCAGGACTGAAATACATTAATGTGGGTGATTTAGCTCGAGAAGAGCAATTG
TATGATGGCTATGATGAAGAGTATGACTGTCCCATTTTAGATGAAGACAGAGTAGTTGAT
GAGTTAGATAACCAAATGAGAGAAGGTGGAGTTATTGTTGATTACCATGGTTGTGATTTC
TTCCCTGAACGCTGGTTTCATATAGTTTTTGTGCTGAGAACAGATACCAATGTATTGTAC
GAAAGACTTGAAACAAGGGGTTATAATGAGAAGAAACTAACAGACAATATTCAGTGTGAG
ATTTTTCAAGTTCTTTATGAAGAAGCCACAGCATCCTACAAGGAAGAAATCGTGCATCAG
CTGCCCAGTAATAAACCAGAAGAGCTAGAAAATAATGTAGATCAGATCTTGAAATGGATT
GAGCAGTGGATCAAAGATCATAACTCTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:49151
Chromosome Location5
LocusNot Available
References
  1. Santama N, Ogg SC, Malekkou A, Zographos SE, Weis K, Lamond AI: Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. J Biol Chem. 2005 Oct 28;280(43):36429-41. Epub 2005 Aug 2. 16079131
  2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. 10810093
  3. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9543-8. 10931946
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  6. Ren H, Liang Y, Li R, Ding H, Qiu S, Lu S, An J, Li L, Luo M, Zheng X, Su XD: Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004. Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1292-4. Epub 2004 Jun 22. 15213396
  7. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460
  8. Ren H, Wang L, Bennett M, Liang Y, Zheng X, Lu F, Li L, Nan J, Luo M, Eriksson S, Zhang C, Su XD: The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):303-8. Epub 2005 Jan 3. 15630091
  9. Drakou CE, Malekkou A, Hayes JM, Lederer CW, Leonidas DD, Oikonomakos NG, Lamond AI, Santama N, Zographos SE: hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Proteins. 2012 Jan;80(1):206-20. doi: 10.1002/prot.23186. Epub 2011 Oct 31. 22038794