Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2587 | Maitotoxin 59392-53-9 | C164H256Na2O68S2 3425.856 g/mol |  |
| Maitotoxin activates calcium permeable, non-selective cation channels, leading to an increase in levels of cytosolic calcium ions. It is thought that maitotoxin leads ...more Number of Targets: 0 |
| T3D2462 | Palytoxin 77734-91-9 | C129H223N3O53 2664.139 g/mol |  |
| Palytoxin targets the sodium-potassium pump protein by binding to the molecule such that the molecule is locked in a position where it allows passive transport of both...more Number of Targets: 9 |
| T3D2512 | Iberiotoxin 129203-60-7 | Not Available 4253.920 g/mol |  |
| Iberiotoxin binds to the outer face of the large-conductance calcium-activated potassium channels with high affinity. It selectively inhibits the current by decreasin...more Number of Targets: 5 |
| T3D2487 | Apamin (Apis mellifera) 24345-16-2 | Not Available 5223.305 g/mol |  |
| Apamin binds to the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them, likely by acting as a pore blocker. Inhi...more Number of Targets: 3 |
| T3D2463 | Ciguatoxin 1 11050-21-8 | C60H86O19 1111.313 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2464 | Ciguatoxin 2 142185-85-1 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2465 | 54-Deoxyciguatoxin 139341-09-6 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2466 | Ciguatoxin 4B 123676-76-6 | C60H84O16 1061.299 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D2537 | alpha-Bungarotoxin 11032-79-4 | Not Available 10285.030 g/mol |  |
| alpha-Bungarotoxin binds irreversibly and competitively to muscular and neuronal nicotinic acetylcholine receptors. This produces peripheral paralysis by blocking neur...more Number of Targets: 8 |
| T3D2538 | beta-Bungarotoxin 12778-32-4 | Not Available 9571.020 g/mol |  |
| beta-Bungarotoxin acts at the presynaptic terminal, where it causes release of acetylcholine and subsequent exhaustion of acetylcholine stores in the nerve terminal by...more Number of Targets: 23 |
| T3D4128 | Brevetoxin B 79580-28-2 | C50H70O14 895.082 g/mol |  |
| Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness c...more Number of Targets: 1 |
| T3D2645 | Brevetoxin 98112-41-5 | C49H68O14 881.056 g/mol |  |
| Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes. (L1112) Number of Targets: 14 |
| T3D2672 | Azaspiracid 214899-21-5 | C47H71NO12 842.066 g/mol |  |
| Azaspiracid-4 dose-dependent inhibits the increase in cytosolic Ca2+ levels induced by thapsigargin (Tg) (A330). Azaspiracid-2 and Azaspiracid-3 clearly increase cytos...more Number of Targets: 1 |
| T3D4322 | Uroporphyrin III 18273-06-8 | C40H38N4O16 830.747 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4324 | Uroporphyrin I 607-14-7 | C40H38N4O16 830.747 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D4447 | Propionyl-CoA 317-66-8 | C24H40N7O17P3S 823.597 g/mol |  |
| In propionic aciduria, propionyl CoA accumulates within the mitochondria in massive quantities; free carnitine is then esterified, creating propionyl carnitine, which ...more Number of Targets: 0 |
| T3D4030 | Dinophysistoxin 1 81720-10-7 | C45H70O13 819.030 g/mol |  |
| Dinophysistoxin 1 (DTX1) is the analogue of okadaic acid causing diarrheic shellfish poisoning (DSP) in humans shortly after the ingestion of contaminated seafood. DTX...more Number of Targets: 0 |
| T3D4029 | Okadaic acid 78111-17-8 | C44H68O13 805.003 g/mol |  |
| Okadaic acid (OA) dramatically increases both nerve growth factor (NGF) mRNA content (50-fold) and NGF secretion (100-fold) in astrocytes. Okadaic acid also activated ...more Number of Targets: 1 |
| T3D4467 | Chitin 1398-61-4 | C28H49N3O16 683.699 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D4438 | Coproporphyrinogen III 2624-63-7 | C36H44N4O8 660.757 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4323 | Coproporphyrin III 14643-66-4 | C36H38N4O8 654.709 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4759 | Liothyronine 6893-02-3 | C15H12I3NO4 650.974 g/mol |  |
| The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid horm...more Number of Targets: 10 |
| T3D4056 | Debromoaplysiatoxin 52423-28-6 | C32H48O10 592.718 g/mol |  |
| Debromoaplysiatoxin have the ability to evoke biological and biochemical responses in cells, and belong to the TPA (12-O-tetradecanoylphorbol 13-acetate) type tumor pr...more Number of Targets: 0 |
| T3D4350 | Bilirubin 635-65-4 | C33H36N4O6 584.662 g/mol |  |
| Not Available Number of Targets: 2 |