Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0301 | Arsenobetaine 64436-13-1 | C5H11AsO2 178.061 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0302 | Arsenocholine 39895-81-3 | C5H14AsO 165.085 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0303 | Methylarsine 593-52-2 | CH5As 91.972 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0304 | Dimethylarsine 593-57-7 | C2H7As 105.999 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0903 | 3-Hydroxy-carbofuran 16655-82-6 | C12H15NO4 237.252 g/mol |  |
| 3-Hydroxy-carbofuran is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the ac...more Number of Targets: 2 |
| T3D0905 | 3-Oxo-carbofuran 16709-30-1 | C12H13NO4 235.236 g/mol |  |
| 3-Oxo-carbofuran is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active...more Number of Targets: 2 |
| T3D2462 | Palytoxin 77734-91-9 | C129H223N3O53 2664.139 g/mol |  |
| Palytoxin targets the sodium-potassium pump protein by binding to the molecule such that the molecule is locked in a position where it allows passive transport of both...more Number of Targets: 9 |
| T3D2463 | Ciguatoxin 1 11050-21-8 | C60H86O19 1111.313 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2464 | Ciguatoxin 2 142185-85-1 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2465 | 54-Deoxyciguatoxin 139341-09-6 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2466 | Ciguatoxin 4B 123676-76-6 | C60H84O16 1061.299 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2477 | Insulin 11061-68-0 | Not Available 11980.795 g/mol |  |
| Insulin has a direct inhibitory effect on the lipase concerned with the mobilization of fattty acids. Insulin binds to a receptor on the surface of the target cell and...more Number of Targets: 56 |
| T3D2484 | Tetrodotoxin 4368-28-9 | C11H17N3O8 319.268 g/mol |  |
| Tetrodotoxin binds to what is known as site 1 of the fast voltage-gated sodium channel. Site 1 is located at the extracellular pore opening of the ion channel. The bin...more Number of Targets: 14 |
| T3D2487 | Apamin (Apis mellifera) 24345-16-2 | Not Available 5223.305 g/mol |  |
| Apamin binds to the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them, likely by acting as a pore blocker. Inhi...more Number of Targets: 3 |
| T3D2489 | Philanthotoxin 77108-00-0 | C23H41N5O3 435.603 g/mol |  |
| Philanthotoxins block glutamate receptors, especially the calcium permeable AMPA receptor and kainate receptor. (L1016) Number of Targets: 9 |
| T3D2490 | alpha-Pompilidotoxin 202075-91-0 | Not Available 1530.850 g/mol |  |
| Pompilidotoxin slows down inactivation of neuronal, but not heart sodium channels, potentiating synaptic transmission. This is believed to be done by binding to the n...more Number of Targets: 10 |
| T3D2491 | beta-Pompilidotoxin 216064-36-7 | Not Available 1558.860 g/mol |  |
| Pompilidotoxin slows down inactivation of neuronal, but not heart sodium channels, potentiating synaptic transmission. This is believed to be done by binding to the n...more Number of Targets: 10 |
| T3D2492 | Holocyclotoxin 88254-04-0 | Not Available 7834.125 g/mol |  |
| Holocyclotoxin produces paralysis by acting at the neuromuscular junction. (A2834) Number of Targets: 0 |
| T3D2493 | Poneratoxin 137084-94-7 | Not Available 2757.330 g/mol |  |
| Poneratoxin affects voltage-dependent sodium ion channels and is known to block nicotinic synaptic transmission in the insect central nervous system. (L1019) Number of Targets: 14 |
| T3D2494 | omega-Agatoxin 145017-83-0 | Not Available 12807.575 g/mol |  |
| omega-Agatoxins block the calcium channels in the presynaptic terminals of the neuromuscular junction in insects and vertebrates. This reduces calcium influx, resultin...more Number of Targets: 1 |
| T3D2495 | Atracotoxin, omega- (Hadronyche versuta) 193981-10-1 | Not Available 4055.410 g/mol |  |
| omega-Atracotoxins inhibit invertebrate voltage-gated calcium channel currents. (T170, L1812) Number of Targets: 0 |
| T3D2496 | Versutoxin 114264-83-4 | Not Available 4855.645 g/mol |  |
| Versutoxin inhibits both insect and mammalian voltage-gated sodium channels. It binds to site 3 in tetrodotoxin-sensitive sodium channels, which slows their inactivati...more Number of Targets: 14 |
| T3D2497 | Robustoxin 91728-12-0 | Not Available 4856.685 g/mol |  |
| Robustoxin inhibits both insect and mammalian voltage-gated sodium channels. It binds to site 3 in tetrodotoxin-sensitive sodium channels, which slows their inactivati...more Number of Targets: 14 |
| T3D2498 | Grammotoxin 152617-90-8 | Not Available 9600.980 g/mol |  |
| Grammotoxin inhibits P-, Q- and N-type voltage-gated calcium channels in neurons. Binding to the calcium channels modifies their voltage-dependent gating. This makes i...more Number of Targets: 3 |
| T3D2499 | Huwentoxin 526224-73-7 | Not Available 9318.830 g/mol |  |
| Huwentoxin blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor, which affects the release of neurotransmitters from autonomic nerve en...more Number of Targets: 17 |