Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D2580 | Mastoparan (Vespa tropica) 72093-21-1 | Not Available 1625.055 g/mol |  |
| Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the rele...more Number of Targets: 0 |
| T3D2581 | Hongotoxin 203526-59-4 | Not Available 4226.080 g/mol |  |
| Hongotoxin inhibits voltage-gated potassium channels. (L1049) Number of Targets: 4 |
| T3D2582 | Maurocalcin 269745-22-4 | Not Available 3864.570 g/mol |  |
| Maurocalcin potently and reversibly modifies channel gating behaviour of the type 1 ryanodine receptor by inducing prominent subconductance behaviour. (T170) Number of Targets: 1 |
| T3D2584 | Myotoxin (Crotalus viridis viridis) 132821-30-8 | Not Available 4827.755 g/mol |  |
| Myotoxins work by a non-enzymatic mechanism that leads to severe muscle necrosis, causing paralysis and eventually death. They may also modify voltage-sensitive sodium...more Number of Targets: 14 |
| T3D2585 | Taipoxin 52019-39-3 | Not Available 13828.660 g/mol |  |
| Taipoxin causes a gradual reduction to complete stop of evoked and spontaneous release of acetylcholine from motor nerve terminals. (L1106) Number of Targets: 0 |
| T3D2587 | Maitotoxin 59392-53-9 | C164H256Na2O68S2 3425.856 g/mol |  |
| Maitotoxin activates calcium permeable, non-selective cation channels, leading to an increase in levels of cytosolic calcium ions. It is thought that maitotoxin leads ...more Number of Targets: 0 |
| T3D2589 | Anthopleurin (Anthopleura xanthogrammica) 600880-63-9 | Not Available 5137.770 g/mol |  |
| Anthopleurin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of m...more Number of Targets: 14 |
| T3D2590 | Calitoxin 118354-83-9 | Not Available 8727.960 g/mol |  |
| Calitoxin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mamm...more Number of Targets: 14 |
| T3D2624 | Melittin (Apis mellifera) 20449-79-0 | Not Available 7584.775 g/mol |  |
| Melittin has strong haemolytic activity. It integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged p...more Number of Targets: 12 |
| T3D2625 | Lopap Not Available | Not Available 22432.280 g/mol | |
| Lopap activates thrombin by cleavage of prothrombin, causing thrombus formation, fibrinogen depletion, uncoagulable blood, decreased platelet count, inhibition of coll...more Number of Targets: 0 |
| T3D2626 | alpha-Agatoxin 128549-96-2 | C26H47N7O2 489.697 g/mol |  |
| alpha-Agatoxins block the glutamate-activated receptor channels in the neuronal postsynaptic terminals of insects and mammals, preventing excitory junction potential f...more Number of Targets: 11 |
| T3D2627 | mu-Agatoxin 120500-28-9 | Not Available 4272.715 g/mol |  |
| mu-Agatoxins modify presynaptic voltage-activated sodium channels in the neuromuscular joints of insects. Modifying sodium channels leads to an increased sensitivity o...more Number of Targets: 0 |
| T3D2628 | kappa-Atracotoxin (Hadronyche versuta) Not Available | Not Available 3685.155 g/mol |  |
| kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) Number of Targets: 0 |
| T3D2629 | Hanatoxin 170780-01-5 | Not Available 4120.690 g/mol |  |
| Hanatoxin inhibits voltage-gated potassium channels by altering the gating energetics, which it does by occupying multiple binding sites on the channel. It can also in...more Number of Targets: 3 |
| T3D2630 | Sphingomyelinase D (Loxosceles intermedia) 9031-54-3 | Not Available 34158.125 g/mol |  |
| Sphingomyelinase D catalyzes the hydrolysis of sphingomyelin, inducing complement-dependent haemolysis, dermonecrosis, blood vessel permeability and platelet aggregati...more Number of Targets: 0 |
| T3D2631 | Heteroscodratoxin Not Available | Not Available 4003.400 g/mol |  |
| Heteroscodratoxin inhibits voltage-gated potassium channels by binding to the extracellular linker of the channel and shifting activation of the channel to more depola...more Number of Targets: 5 |
| T3D2633 | Acanthophin 126601-49-8 | Not Available 8386.795 g/mol | |
| Acanthophin produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. It does this by binding to certain muscular and neuronal nic...more Number of Targets: 8 |
| T3D2635 | Erabutoxin 59536-69-5 | Not Available 9136.510 g/mol |  |
| Erabutoxin binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. This produces peripheral ...more Number of Targets: 6 |
| T3D2636 | Disintegrin echistatin (Echis carinatus) Not Available | Not Available 5424.090 g/mol |  |
| Disintegrins work by countering blood clotting steps, inhibiting the clumping of platelets. They inhibit fibrinogen interaction with platelet receptors expressed on gl...more Number of Targets: 2 |
| T3D2637 | Nigroxin 9001-84-7 | Not Available 13341.125 g/mol |  |
| Nigroxin is myotoxic. (T170) Number of Targets: 0 |
| T3D2638 | Notexin 37233-96-4 | Not Available 13593.310 g/mol |  |
| Notexin is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (T170) Number of Targets: 0 |
| T3D2639 | Ohanin Not Available | Not Available 21173.945 g/mol | |
| Ohanin is extremely neurotoxic, cardiotoxic, and cytotoxic. (L1102) Number of Targets: 0 |
| T3D2640 | Pseudechetoxin Not Available | Not Available 26474.445 g/mol |  |
| Pseudechetoxin blocks olfactory and retinal cyclic nucleotide-gated (CNG) ion channel currents. It forms high-affinity contacts with the pore turret region and most li...more Number of Targets: 2 |
| T3D2642 | Viperotoxin Not Available | Not Available 15554.775 g/mol |  |
| Viperotoxin is a presynaptic neurotoxin. (T170) Number of Targets: 0 |