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Browsing Toxins By Category
T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
---|---|---|---|---|---|
T3D0141 | S,S,S-Tributyl phosphorotrithioate 78-48-8 | C12H27OPS3 314.511 g/mol |
| S,S,S-Tributyl phosphorotrithioate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the ac...more Number of Targets: 17 | |
T3D0142 | Bromine 7726-95-6 | Br2 159.808 g/mol |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 7 | |
T3D0144 | Dicofol 115-32-2 | C14H9Cl5O 370.486 g/mol |
| Like other organochloride pesticides, dicofol is believed to act by at least four mechanisms, possibly all functioning simultaneously. It may reduce potassium transpor...more Number of Targets: 74 | |
T3D0145 | Parathion 56-38-2 | C10H14NO5PS 291.261 g/mol |
| Parathion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 17 | |
T3D0146 | 1,1,2,2-Tetrachloroethane 79-34-5 | C2H2Cl4 167.849 g/mol |
| The presence of the functional group consisting of a terminal dichloromethyl moiety in a molecule is known to confer toxicity. Moreover, the metabolism of 1,1,2,2-tetr...more Number of Targets: 39 | |
T3D0147 | Selenium 7782-49-2 | Se 78.960 g/mol |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 | |
T3D0148 | Hexachlorocyclohexane, technical Grade 608-73-1 | C6H6Cl6 290.830 g/mol |
| Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro...more Number of Targets: 32 | |
T3D0151 | O,P'-DDD 53-19-0 | C14H10Cl4 320.041 g/mol |
| DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti...more Number of Targets: 43 | |
T3D0152 | 4,4'-Methylenebis(2-chloroaniline) 101-14-4 | C13H12Cl2N2 267.154 g/mol |
| MBOCA's carcinogenicity is thought to be a result of its ability to bind to DNA, hemoglobin, and serum albumin. One metabolite in particular, N-hydroxy-N,N’-diacetyl M...more Number of Targets: 49 | |
T3D0156 | 1,3-Butadiene 106-99-0 | C4H6 54.090 g/mol |
| Certain metabolites of 1,3-butadiene have been shown to bind to DNA and nucleoproteins, forming protein-DNA and DNA-DNA crosslinks. Specifically, 1,2-epoxybutene-3 and...more Number of Targets: 2 | |
T3D0157 | Ammonia 7664-41-7 | H3N 17.031 g/mol |
| The topical damage caused by ammonia is probably due mainly to its alkaline properties. Its high water solubility allows it to dissolve in moisture on the mucous membr...more Number of Targets: 2 | |
T3D0158 | 2-Methylnaphthalene 91-57-6 | C11H10 142.197 g/mol |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 4 | |
T3D0159 | 1,4-Dichlorobenzene 106-46-7 | C6H4Cl2 147.002 g/mol |
| The hepatotoxicity and nephrotoxicity observed in laboratory animals are likely due to the formation of toxic intermediates formed while converting 1,4-DCB to 2,5-dich...more Number of Targets: 40 | |
T3D0160 | 1,1-Dichloroethane 75-34-3 | C2H4Cl2 98.959 g/mol |
| The limited information available about 1,1-dichloroethane suggests that it may be nephrotoxic, fetotoxic, and possibly carcinogenic. 1,1-Dichloroethane has been obser...more Number of Targets: 40 | |
T3D0161 | Acenaphthene 83-32-9 | C12H10 154.208 g/mol |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 | |
T3D0162 | 1,2,3,4,6,7,8,9-Octachlorodibenzofuran 39001-02-0 | C12Cl8O 443.752 g/mol |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 | |
T3D0163 | 1,1,2-Trichloroethane 79-00-5 | C2H3Cl3 133.404 g/mol |
| Acyl chlorides and free radicals formed during the metabolism of 1,1,2-trichloroethane are reactive metabolites that can bind to proteins and nucleic acids (DNA, RNA),...more Number of Targets: 5 | |
T3D0165 | Hexachlorocyclopentadiene 77-47-4 | C5Cl6 272.772 g/mol |
| HCCPD may interact with the microsomes that binds to secretory molecules and changes their ability to be transported from the cell. It can be postulated, that some of ...more Number of Targets: 42 | |
T3D0166 | 1,2,3,4,6,7,8-Heptachlorodibenzofuran 38998-75-3 | C12HCl7O 409.307 g/mol |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 | |
T3D0167 | 1,2-Diphenylhydrazine 122-66-7 | C12H12N2 184.237 g/mol |
| Two of the known metabolites, aniline and benzidine, may contribute to the toxicity and/or carcinogenicity of 1,2-diphenylhydrazine. Nonneoplastic liver lesions, hepat...more Number of Targets: 3 | |
T3D0168 | 2,3,4,7,8-Pentachlorodibenzofuran 57117-31-4 | C12H3Cl5O 340.417 g/mol |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 | |
T3D0170 | p-Cresol 106-44-5 | C7H8O 108.138 g/mol |
| p-Cresol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 5 | |
T3D0172 | 1,2-Dichlorobenzene 95-50-1 | C6H4Cl2 147.002 g/mol |
| 1,2-DCB was found to covalently bind to DNA, RNA, and proteins of liver, kidney, lung, and stomach. (L395) Number of Targets: 42 | |
T3D0173 | trans-1,2-Dichloroethene 156-60-5 | C2H2Cl2 96.943 g/mol |
| Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids a...more Number of Targets: 4 | |
T3D0174 | Indeno(1,2,3-cd)pyrene 193-39-5 | C22H12 276.331 g/mol |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |