25
T3D0024
Aldrin
Aldrin is a chlorinated hydrocarbon used as an insecticide. Once in the insect, aldrin is oxidized into dieldrin, a neurotoxin. Due to the toxicity and ability of bioaccumulate of dieldrin, the use of aldrin is now banned in most parts of the world. (L144)
309-00-2
61103
C12H8Cl6
361.875720
White powder.
104°C
1.7e-05 mg/mL at 25 °C [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Oral (L87) ; inhalation (L87) ; dermal (L87)
Gamma-aminobutyric acid receptor subunit alpha-1 (P14867)
Gamma-aminobutyric acid receptor subunit alpha-2 (P47869)
Gamma-aminobutyric acid receptor subunit alpha-3 (P34903)
Gamma-aminobutyric acid receptor subunit alpha-4 (P48169)
Gamma-aminobutyric acid receptor subunit alpha-5 (P31644)
Gamma-aminobutyric acid receptor subunit alpha-6 (Q16445)
Gamma-aminobutyric acid receptor subunit beta-1 (P18505)
Gamma-aminobutyric acid receptor subunit beta-2 (P47870)
Gamma-aminobutyric acid receptor subunit beta-3 (P28472)
Gamma-aminobutyric acid receptor subunit delta (O14764)
Gamma-aminobutyric acid receptor subunit gamma-1 (Q8N1C3)
Gamma-aminobutyric acid receptor subunit gamma-2 (P18507)
Gamma-aminobutyric acid receptor subunit gamma-3 (Q99928)
Gamma-aminobutyric acid receptor subunit pi (O00591)
Gamma-aminobutyric acid receptor subunit rho-1 (P24046)
Gamma-aminobutyric acid receptor subunit rho-2 (P28476)
Gamma-aminobutyric acid receptor subunit rho-3 (A8MPY1)
Gamma-aminobutyric acid receptor subunit theta (Q9UN88)
Sodium/potassium-transporting ATPase subunit alpha-1 (P05023)
Sodium/potassium-transporting ATPase subunit alpha-2 (P50993)
Sodium/potassium-transporting ATPase subunit alpha-3 (P13637)
Sodium/potassium-transporting ATPase subunit alpha-4 (Q13733)
Sodium/potassium-transporting ATPase subunit beta-1 (P05026)
Sodium/potassium-transporting ATPase subunit beta-2 (P14415)
Sodium/potassium-transporting ATPase subunit beta-3 (P54709)
Sodium/potassium-transporting ATPase gamma chain (P54710)
Calcium-transporting ATPase type 2C member 1 (P98194)
Calcium-transporting ATPase type 2C member 2 (O75185)
Plasma membrane calcium-transporting ATPase 1 (P20020)
Plasma membrane calcium-transporting ATPase 2 (Q01814)
Plasma membrane calcium-transporting ATPase 3 (Q16720)
Plasma membrane calcium-transporting ATPase 4 (P23634)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (O14983)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (Q93084)
(T10, L87)
Aldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. Aldrin also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. (T10, L87)
Aldrin is absorbed throught the gastrointestinal tract, lungs and skin. Following absorption, aldrin is redistributed primarily to fat via the lymphatic system. Once in the body, aldrin is readily converted to dieldrin, primarily in the liver by mixed-function oxidases of the cytochrome P-450 system, and to a lesser extent in the lung and skin. Aldrin may also be epoxidized to dieldrin by a prostaglandin synthetase-mediated pathway inextrahepatic tissues. Dieldrin is metabolized by liver microsomal monooxygenases and epoxide hydratases. Its metabolites, of which the primary one is 9-hydroxydieldrin, are excreted in the faeces. (L87)
LD50: 39 mg/kg (Oral, Rat) (T18)
LD50: 98 mg/kg (Dermal, Rat) (T18)
LD50: 150 mg/kg (Intraperitoneal, Rat) (T17)
LD50: 21 mg/kg (Intravenous, Mouse) (T17)
5 to 7 grams for an adult human. (T19)
3, not classifiable as to its carcinogenicity to humans. (L135)
Aldrin is used as an insecticide. (L144)
Acute Oral: 0.002 mg/kg/day (L134)
Chronic Oral: 0.00003 mg/kg/day (L134)
Aldrin is a neurotoxin and works by overstimulating the central nervous system. Ingestion of large amounts of aldrin causes convulsions and death. However, chronic exposure to lower amounts of aldrin also has adverse affects because it is oxidized to dieldrin, which accumulates in the body. Dieldrin is known to damage the nervous system, liver, and immune system. (L87)
Exposure to aldrin results in headaches, dizziness, irritability, nausea and vomiting, cardiac arrhythmias, muscular weakness, uncontrolled muscle movements, hyperexcitability, seizures and coma. (L87)
Treatment is symptomatic, aimed at controlling convulsions, coma, and respiratory depression. If ingested, gastric lavage may be performed, followed by administering activated charcoal powder. (L145)
2009-03-06T18:57:56Z
2014-12-24T20:20:54Z
Cytochrome P450 1A1 (P04798)
Cytochrome P450 1A2 (P05177)
Cytochrome P450 1B1 (Q16678)
Epoxide hydrolase 1 (P07099)
Epoxide hydrolase 2 (P34913)
(L87)
http://en.wikipedia.org/wiki/Aldrin
C07552
2564
D000452
Aldrin
41
true
Cytochrome P450 1A1 (P04798)
Cytochrome P450 1A2 (P05177)
Cytochrome P450 1B1 (Q16678)
Epoxide hydrolase 1 (P07099)
Epoxide hydrolase 2 (P34913)
(L87)
ClC1=C(Cl)[C@]2(Cl)C3C4CC(C=C4)C3[C@@]1(Cl)C2(Cl)Cl
C12H8Cl6
InChI=1/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4?,5?,6?,7?,10-,11+
InChIKey=QBYJBZPUGVGKQQ-LYSYVJQENA-N
364.91
361.875716498
Exogenous
Solid
10292747