113
T3D0112
n-Nitrosodi-n-propylamine
N-Nitrosodi-n-propylamine is a chemical produced by industry in small amounts for research. Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. It is one ingredient of cigarette. (L216)
621-64-7
12130
C6H14N2O
130.110610
Yellow liquid.
206 °C
13 mg/mL at 24 °C [MIRVISH,SS et al.(1976)]
Oral (L216); inhalation (L216) ; dermal (L216).
Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216)
n-Nitrosodi-n-propylamine can be absorbed through oral, inhalation, or dermal routes. It is metabolized by cytochrome p-450 enzymes (mainly CYP 2E1) into its reactive metabolites via oxidation at the alpha, beta and gamma carbon positions. Alpha carbon oxidation is regarded as the primary pathway, resulting in formation of propionaldehyde, 1-propanol, and 2-propanol. The metabolites of n-nitrosodi-n-propylamine are excreted mainly in the urine. (L216, A152)
LD50: 480 mg/kg (Oral, Rat) (T35)
LD50: 487 mg/kg (Subcutaneous, Rat) (T35)
2B, possibly carcinogenic to humans. (L135)
Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. (L216)
Acute Oral: 0.095 mg/kg/day (L134)
High levels of n-nitrosodi-n-propylamine may damage the liver, lung, stomach, kidneys, and heart. n-Nitrosodi-n-propylamine is also a likely carcinogen. (L216)
2009-03-06T18:58:06Z
2014-12-24T20:21:08Z
Cytochrome P450 2E1 (P05181) (A152)
C19279
CPD-630
C013161
n-Nitrosodi-n-propylamine
1053
true
Cytochrome P450 2E1 (P05181)
(A152)
CCCN(CCC)N=O
C6H14N2O
InChI=1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3
InChIKey=YLKFDHTUAUWZPQ-UHFFFAOYSA-N
130.1882
130.11061308
Exogenous
Solid
CHEMBL166242
11632