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Record Information
Version2.0
Creation Date2009-03-06 18:58:09 UTC
Update Date2014-12-24 20:21:11 UTC
Accession NumberT3D0136
Identification
Common NameNeptunium-237
ClassSmall Molecule
DescriptionNeptunium is a chemical element with the symbol Np and atomic number 93. A radioactive metallic element, neptunium is the first transuranic element and belongs to the actinide series. Its most stable isotope, 237Np, is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. Neptunium is also found in trace amounts in uranium ores due to transmutation reactions. (2)
Compound Type
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Metal
  • Pollutant
  • Radioactive
  • Radioactive Isotope
  • Synthetic Compound
Chemical Structure
Thumb
Synonyms
Synonym
(237)Np
237Np
Neptunium 237
Neptunium, isotope of mass 237
Neptunium, isotope of mass 237 (237Np5+)
Chemical FormulaNp
Average Molecular Mass237.048 g/mol
Monoisotopic Mass237.048 g/mol
CAS Registry Number13994-20-2
IUPAC Name(²³⁷Np)neptunium
Traditional Name(²³⁷Np)neptunium
SMILES[237Np]
InChI IdentifierInChI=1S/Np/i1+0
InChI KeyInChIKey=LFNLGNPSGWYGGD-IGMARMGPSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous actinide compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous actinide compounds
Direct ParentHomogeneous actinide compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous actinide
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceSilver metal.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
LogPNot Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0090000000-46f10cba410914d93b10View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0090000000-46f10cba410914d93b10View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-0090000000-46f10cba410914d93b10View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-0090000000-745220007a4fbbe965f9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-0090000000-745220007a4fbbe965f9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-000i-0090000000-745220007a4fbbe965f9View in MoNA
Toxicity Profile
Route of ExposureOral (1) ; Inhalation (1)
Mechanism of ToxicityThe ionizing radiation produced by neptunium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (1)
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)1, carcinogenic to humans. (4)
Uses/Sources237Np is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. (2)
Minimum Risk LevelNot Available
Health Effects237-Neptunium's radioactivity can cause cancer. (1)
SymptomsExposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (1, 3)
TreatmentTreatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (3)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound ID104783
ChEMBL IDNot Available
ChemSpider ID94588
KEGG IDNot Available
UniProt IDNot Available
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNeptunium-237
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for ionizing radiation. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  2. Wikipedia. Neptunium. Last Updated 19 August 2009. [Link]
  3. Wikipedia. Radiation poisoning. Last Updated 22 August 2009. [Link]
  4. International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

1. DNA
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for ionizing radiation. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]