Record Information
Version2.0 (beta)
Creation Date2009-03-06 11:58:21 -0700
Update Date2014-08-11 10:03:28 -0600
Accession NumberT3D0242
Identification
Common NameMercuric chloride
ClassSmall Molecule
DescriptionMercuric chloride is one of the most toxic chemical compounds of mercury, due to its high solubility in water. It is most often used as a laboratory reagent, and occasionally used to form amalgams with metals.
Compound Type
  • Inorganic Compound
  • Mercury Compound
Chemical Structure
Thumb
Synonyms
  1. Abavit b
  2. Agrosan
  3. Bichloride of mercury
  4. Bichloride, mercury
  5. Bichlorure de mercure
  6. Bichlorure de mercure [french]
  7. Calo-clor
  8. Calochlor
  9. Calocure
  10. Chlorid rtutnaty
  11. Chlorid rtutnaty [czech]
  12. Chloride, mercuric
  13. Chlorure mercurique
  14. Chlorure mercurique [french]
  15. Chlorure mercurique [iso-french]
  16. Clhgcl
  17. Cloruro di mercurio
  18. Cloruro di mercurio [italian]
  19. Corrosive mercury chloride
  20. Corrosive sublimate
  21. Dichloride, mercury
  22. Dichloromercury
  23. Dichlorure de mercure
  24. Emisan 6
  25. Fungchex
  26. HgCl2
  27. Hydraargyrum bichloratum
  28. Hydrargyrum bichloratum
  29. MC
  30. Mercuric bichloride
  31. Mercuric chloride
  32. Mercuric chloride (jan)
  33. Mercuric chloride [iso]
  34. Mercuric chloride [jan]
  35. Mercuric chloride [mercury and mercury compounds]
  36. Mercuric chloride, solid
  37. Mercuric perchloride
  38. Mercury (II ) chloride
  39. Mercury (II) chloride
  40. Mercury bichloride
  41. Mercury chloride
  42. Mercury chloride (2)
  43. Mercury chloride (HgCl(2))
  44. Mercury chloride (HgCl2)
  45. Mercury perchloride
  46. Mercury(I) chloride
  47. Mercury(II) chloride
  48. Perchloride of mercury
  49. Perchloride, mercuric
  50. Perchloride, mercury
  51. Quecksilber chlorid
  52. Quecksilber chlorid [german]
  53. Quecksilber(II)-chlorid
  54. Sublimat
  55. Sublimat (czech)
  56. Sublimat [czech]
  57. Sublimate
  58. Sublimate, corrosive
  59. Sulem
  60. Sulema
  61. Sulema [russian]
  62. dichloromercury
  63. mercury(2+) chloride
  64. mercury(2+) dichloride
Chemical FormulaCl2Hg
Average Molecular Weight271.5 g/mol
CAS Registry Number7487-94-7
Monoisotopic Mass271.908331018 g/mol
IUPAC Namedichloromercury
Traditional IUPAC Namemercuric chloride
SMILESCl[Hg]Cl
InChI IdentifierInChI=1S/2ClH.Hg/h2*1H;/q;;+2/p-2
InChI KeyInChIKey=LWJROJCJINYWOX-UHFFFAOYSA-L
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassMixed Metal/Non Metal Compounds
ClassTransition Metal Salts
Sub ClassTransition Metal Chlorides
Direct ParentTransition Metal Chlorides
Alternative ParentsNot Available
Substituents
  • Acyclic Compound
  • Transition Metal Chloride
External Descriptors
  • Inorganic fungicides(KEGG)
  • mercury coordination entity(ChEBI)
Biological Properties
StatusDetected but not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
Physical Properties
StateNot Available
AppearanceWhite crystals.
Experimental Properties
PropertyValue
Melting Point277 C
Boiling PointNot Available
Solubility69 mg/mL at 20 °C [SHIU,WY et al. (1990)]
LogPNot Available
Predicted Properties
PropertyValueSource
logP0.57ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count0ChemAxon
hydrogen donor count0ChemAxon
polar surface area0ChemAxon
rotatable bond count0ChemAxon
refractivity12.27ChemAxon
polarizability7.27ChemAxon
Spectra
SpectraNot Available
Toxicity Profile
Route of ExposureOral (8) ; inhalation (8) ; dermal (8)
Mechanism of ToxicityHigh-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (8, 4, 5, 6)
MetabolismMercury is absorbed mainly via ingestion and inhalation, then distributed throughout the body via the bloodstream, where a portion binds to sulfhydryl groups on haemoglobin. Mercury can undergo oxidation to mercuric mercury, which takes place via the catalase-hydrogen peroxide pathway. The mercury atom is able to diffuse down the cleft in the catalase enzyme to reach the active site where the heme ring is located. Oxidation most likely occurs in all tissue, as the catalase hydrogen peroxide pathway is ubiquitous. Following oxidation, mercury tends to accumulate in the kidneys. Mercury is excreted mainly by exhalation and in the faeces. (2, 8)
Toxicity ValuesLD50: 1 mg/kg (Oral, Rat) (14) LD50: 5 mg/kg (Intraperitoneal, Mouse) (14) LD50: 14 mg/kg (Subcutaneous, Rat) (14)
Lethal Dose1 gram for an adult human (average for inorganic mercurials). (7)
Carcinogenicity (IARC Classification)3, not classifiable as to its carcinogenicity to humans. (12)
Uses/SourcesMercuric chloride is most often used as a laboratory reagent, and occasionally used to form an amalgam with metals. (13)
Minimum Risk LevelChronic Inhalation: 0.0002 mg/m3 (11)
Health EffectsMercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (8)
SymptomsCommon symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (1)
TreatmentMercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (3)
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound ID24085
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDC13377
UniProt IDNot Available
OMIM IDNot Available
ChEBI ID31823
BioCyc IDNot Available
CTD IDD008627
Stitch IDMercuric chloride
PDB IDNot Available
ACToR ID826
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Horowitz Y, Greenberg D, Ling G, Lifshitz M: Acrodynia: a case report of two siblings. Arch Dis Child. 2002 Jun;86(6):453. [12023189 ]
  2. Clarkson TW, Magos L: The toxicology of mercury and its chemical compounds. Crit Rev Toxicol. 2006 Sep;36(8):609-62. [16973445 ]
  3. Clifton JC 2nd: Mercury exposure and public health. Pediatr Clin North Am. 2007 Apr;54(2):237-69, viii. [17448359 ]
  4. Madsen KM, Christensen EI: Effects of mercury on lysosomal protein digestion in the kidney proximal tubule. Lab Invest. 1978 Feb;38(2):165-74. [203771 ]
  5. Ziemba SE, Menard SL, McCabe MJ Jr, Rosenspire AJ: T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury. FASEB J. 2009 Jun;23(6):1663-71. doi: 10.1096/fj.08-117283. Epub 2009 Jan 23. [19168706 ]
  6. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
  7. Baselt RC (2000). Disposition of Toxic Drugs and Chemicals in Man, 5th ed. Foster City, CA: Chemical Toxicology Institute.
  8. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  9. Wikipedia. Mercury poisoning. Last Updated 8 March 2009. [Link]
  10. Wikipedia. Metallothionein. Last Updated 20 December 2008. [Link]
  11. ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  12. International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. [Link]
  13. Wikipedia. Mercury(II) chloride. Last Updated 17 May 2009. [Link]
  14. The Physical and Theoretical Chemistry Laboratory of Oxford University (2006). Material Safety Data Sheet (MSDS) for mercury (II) chloride . [Link]
Gene Regulation
Up-Regulated Genes
GeneGene SymbolGene IDInteractionReference
Down-Regulated Genes
GeneGene SymbolGene IDInteractionReference

Targets

General function:
Involved in protein kinase activity
Specific function:
Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR
Gene Name:
LCK
Uniprot ID:
P06239
Molecular weight:
57870.0
References
  1. Ziemba SE, Menard SL, McCabe MJ Jr, Rosenspire AJ: T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury. FASEB J. 2009 Jun;23(6):1663-71. doi: 10.1096/fj.08-117283. Epub 2009 Jan 23. [19168706 ]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA1B
Uniprot ID:
P68363
Molecular weight:
50152.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA3C
Uniprot ID:
Q13748
Molecular weight:
49960.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA4A
Uniprot ID:
P68366
Molecular weight:
49925.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB
Uniprot ID:
P07437
Molecular weight:
49671.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
Gene Name:
TUBB2A
Uniprot ID:
Q13885
Molecular weight:
49908.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB2C
Uniprot ID:
P68371
Molecular weight:
49832.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB3
Uniprot ID:
Q13509
Molecular weight:
50433.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB4
Uniprot ID:
P04350
Molecular weight:
49586.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in GTP binding
Specific function:
Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly
Gene Name:
TUBG1
Uniprot ID:
P23258
Molecular weight:
51169.5
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Carbohydrate transport and metabolism
Specific function:
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient
Gene Name:
AQP1
Uniprot ID:
P29972
Molecular weight:
28526.0
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P41181
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q92482
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Carbohydrate transport and metabolism
Specific function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system
Gene Name:
AQP4
Uniprot ID:
P55087
Molecular weight:
34829.4
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P55064
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q13520
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O14520
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O94778
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O43315
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q96PS8
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q8NBQ7
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q8IXF9
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA1A
Uniprot ID:
Q71U36
Molecular weight:
50136.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA1C
Uniprot ID:
Q9BQE3
Molecular weight:
49896.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
Gene Name:
TUBA3E
Uniprot ID:
Q6PEY2
Molecular weight:
49917.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in cell structure
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA8
Uniprot ID:
Q9NY65
Molecular weight:
50094.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB1
Uniprot ID:
Q9H4B7
Molecular weight:
50328.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
Gene Name:
TUBB2B
Uniprot ID:
Q9BVA1
Molecular weight:
49954.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
Gene Name:
TUBB6
Uniprot ID:
Q9BUF5
Molecular weight:
49858.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q3ZCM7
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in GTP binding
Specific function:
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head (By similarity)
Gene Name:
TUBD1
Uniprot ID:
Q9UJT1
Molecular weight:
51033.9
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in GTP binding
Specific function:
Not Available
Gene Name:
TUBE1
Uniprot ID:
Q9UJT0
Molecular weight:
52931.4
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q9NRH3
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Inorganic ion transport and metabolism
Specific function:
This isozyme may play a role in skeletal mineralization
Gene Name:
ALPL
Uniprot ID:
P05186
Molecular weight:
57304.4
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Carbohydrate transport and metabolism
Specific function:
Water channel. May be responsible for regulating the osmolarity of the lens
Gene Name:
MIP
Uniprot ID:
P30301
Molecular weight:
28121.5
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Involved in protein serine/threonine kinase activity
Specific function:
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters
Gene Name:
PRKCA
Uniprot ID:
P17252
Molecular weight:
76765.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in protein serine/threonine kinase activity
Specific function:
This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking
Gene Name:
PRKCB
Uniprot ID:
P05771
Molecular weight:
76870.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in protein serine/threonine kinase activity
Specific function:
This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function
Gene Name:
PRKCD
Uniprot ID:
Q05655
Molecular weight:
77478.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in protein serine/threonine kinase activity
Specific function:
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters
Gene Name:
PRKCE
Uniprot ID:
Q02156
Molecular weight:
83675.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P24723
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P05129
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in ATP binding
Specific function:
Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs)
Gene Name:
PRKCI
Uniprot ID:
P41743
Molecular weight:
68261.9
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in protein serine/threonine kinase activity
Specific function:
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters
Gene Name:
PRKCQ
Uniprot ID:
Q04759
Molecular weight:
81866.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q05513
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
A6NM10
Molecular weight:
Not Available
References
  1. Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63. doi: 10.1042/BC20070132. [18167118 ]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
A6NKZ8
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q99867
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)
Gene Name:
TUBA4B
Uniprot ID:
Q9H853
Molecular weight:
27547.0
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
A6NHL2
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
A6NNZ2
Molecular weight:
Not Available
References
  1. ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for mercury. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q16236
Molecular weight:
Not Available
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active9.91 uMATG_NRF2_ARE_CISAttagene
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58295.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.04 uMNVS_ADME_hCYP1A2Novascreen
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.8
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active7.00 uMNVS_ADME_hCYP2B6Novascreen
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55930.5
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.80 uMNVS_ADME_hCYP2C19Novascreen
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55629.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active3.55 uMNVS_ADME_hCYP2C9Novascreen
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55770.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active2.45 uMNVS_ADME_hCYP2D6Novascreen
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P05184
Molecular weight:
Not Available
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.99 uMNVS_ADME_hCYP3A4Novascreen
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P47898
Molecular weight:
Not Available
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.54 uMNVS_GPCR_h5HT5ANovascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs
Gene Name:
HTR6
Uniprot ID:
P50406
Molecular weight:
46955.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.61 uMNVS_GPCR_h5HT6Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
Gene Name:
HTR7
Uniprot ID:
P34969
Molecular weight:
53556.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.83 uMNVS_GPCR_h5HT7Novascreen
General function:
Involved in A2A adenosine receptor activity, G-protein coupled
Specific function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Gene Name:
ADORA2A
Uniprot ID:
P29274
Molecular weight:
44708.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active5.16 uMNVS_GPCR_hAdoRA2aNovascreen
General function:
Involved in alpha2-adrenergic receptor activity
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48957.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active2.25 uMNVS_GPCR_hAdra2ANovascreen
General function:
Involved in alpha2-adrenergic receptor activity
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular weight:
49523.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.23 uMNVS_GPCR_hAdra2CNovascreen
General function:
Involved in beta1-adrenergic receptor activity
Specific function:
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular weight:
51323.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.30 uMNVS_GPCR_hAdrb1Novascreen
General function:
Involved in beta2-adrenergic receptor activity
Specific function:
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular weight:
46557.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.92 uMNVS_GPCR_hAdrb2Novascreen
General function:
Involved in angiotensin type II receptor activity
Specific function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system
Gene Name:
AGTR1
Uniprot ID:
P30556
Molecular weight:
41062.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active9.83 uMNVS_GPCR_hAT1Novascreen
General function:
Involved in dopamine receptor activity
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular weight:
49294.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.19 uMNVS_GPCR_hDRD1Novascreen
General function:
Involved in dopamine receptor activity
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular weight:
50620.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.35 uMNVS_GPCR_hDRD2sNovascreen
General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Gene Name:
DRD4
Uniprot ID:
P21917
Molecular weight:
48361.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.55 uMNVS_GPCR_hDRD4.4Novascreen
General function:
Involved in endothelin receptor activity
Specific function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is:ET1 > ET2 >> ET3
Gene Name:
EDNRA
Uniprot ID:
P25101
Molecular weight:
48723.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active2.96 uMNVS_GPCR_hETANovascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular weight:
55785.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.94 uMNVS_GPCR_hH1Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Gene Name:
CHRM1
Uniprot ID:
P11229
Molecular weight:
51421.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.10 uMNVS_GPCR_hM1Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition
Gene Name:
CHRM2
Uniprot ID:
P08172
Molecular weight:
51716.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.10 uMNVS_GPCR_hM2Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Gene Name:
CHRM3
Uniprot ID:
P20309
Molecular weight:
66129.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.49 uMNVS_GPCR_hM3Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase
Gene Name:
CHRM4
Uniprot ID:
P08173
Molecular weight:
53050.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active5.50 uMNVS_GPCR_hM4Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Gene Name:
CHRM5
Uniprot ID:
P08912
Molecular weight:
60074.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.35 uMNVS_GPCR_hM5Novascreen
General function:
Not Available
Specific function:
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system
Gene Name:
TACR2
Uniprot ID:
P21452
Molecular weight:
44440.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active3.41 uMNVS_GPCR_hNK2Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid
Gene Name:
NPY2R
Uniprot ID:
P49146
Molecular weight:
42732.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active7.83 uMNVS_GPCR_hNPY2Novascreen
General function:
Involved in delta-opioid receptor activity
Specific function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular weight:
40413.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.26 uMNVS_GPCR_hOpiate_D1Novascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular weight:
44780.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.18 uMNVS_GPCR_hOpiate_muNovascreen
General function:
Involved in rhodopsin-like receptor activity
Specific function:
Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase
Gene Name:
OPRL1
Uniprot ID:
P41146
Molecular weight:
40694.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.31 uMNVS_GPCR_hORL1Novascreen
General function:
Involved in DNA binding
Specific function:
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular weight:
85660.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active3.49 uMNVS_NR_hGRNovascreen
General function:
Involved in nucleoside transmembrane transporter activity
Specific function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)
Gene Name:
SLC29A1
Uniprot ID:
Q99808
Molecular weight:
50220.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active5.01 uMNVS_TR_hAdoTNovascreen
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular weight:
69333.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.36 uMNVS_TR_hNETNovascreen
General function:
Involved in DNA binding
Specific function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Activated, but not phosphorylated, by HIPK3
Gene Name:
AR
Uniprot ID:
P10275
Molecular weight:
98990.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active1.45 uMTox21_AR_BLA_Agonist_ratioTox21/NCGC
General function:
Involved in DNA binding
Specific function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular weight:
57621.0
References
  1. ToxCastDB (EPA, United States Environmental Protection Agency) [Link]

Constants

TypeValueAssay TypeAssay Source
Active0.86 uMTox21_PPARg_BLA_Agonist_ratioTox21/NCGC