348
T3D0347
Mercury cadmium telluride
Mercury cadmium telluride is an alloy of mercury telluride and cadmium telluride. It is an important semiconductor and also used in infrared detection. Mercury is a heavy, silvery d-block metal and one of six elements that are liquid at or near room temperature and pressure. It is a naturally occuring substance, and combines with other elements such as chlorine, sulfur, or oxygen to form inorganic mercury compounds (salts). Mercury also combines with carbon to make organic mercury compounds. (L1, L433)
29870-72-2
94407
CdHgTe
445.780210
Black crystals.
Oral (L7) ; inhalation (L7); dermal (L7)
Catalase (P04040) Radical S-adenosyl methionine domain-containing protein 1 (Q9HA92) Radical S-adenosyl methionine domain-containing protein 2 (Q8WXG1) Proto-oncogene tyrosine-protein kinase LCK (P06239) (L22)
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high weight molecular proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (L7, A8, L8, A18, A19, A25, A26, A28)
Cadmium and mercury may be absorbed from oral, inhalation, and dermal routes. Mercury is distributed throughout the body via the bloodstream, where a portion binds to sulfhydryl groups on haemoglobin. Mercury can undergo oxidation to mercuric mercury, which takes place via the catalase-hydrogen peroxide pathway. The mercury atom is able to diffuse down the cleft in the catalase enzyme to reach the active site where the heme ring is located. Oxidation most likely occurs in all tissue, as the catalase hydrogen peroxide pathway is ubiquitous. Following oxidation, mercury tends to accumulate in the kidneys. Mercury is excreted mainly by exhalation and in the faeces. Cadmium initially binds to metallothionein and albumin and is transported mainly to the kidney and liver. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Cadmium is not known to undergo any direct metabolic conversion and is excreted unchanged, mainly in the urine. (L6, A6, L7)
1 gram for an adult human (average for inorganic mercurials). (T17)
1, carcinogenic to humans. (L135)
Mercury cadmium telluride is an important semiconductor and also used in infrared detection. (L433)
Chronic Inhalation: 0.0002 mg/m3 (Mercury) (L134)
Acute Inhalation: 0.00003 mg/m3 (Cadmium) (L134)
Chronic Inhalation: 0.00001 mg/m3 (Cadmium) (L134)
Intermediate Oral: 0.0005 mg/kg/day (Cadmium) (L134)
Chronic Oral: 0.0001 mg/kg/day (Cadmium) (L134)
Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. Chronic exposure to cadmium fumes can cause chemical pneumonitis, pulmonary edema, and lung diseases such as bronchitis and emphysema. Cadmium also accumulates in the kidneys, causing permanent damage. Loss of bone density also occurs. (L6, L7)
Common symptoms of mercury poisoning include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). Acute inhalation of cadmium fumes results in metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Ingestion of cadmium causes vomiting and diarrhea. (L6, A5)
Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. Cadmium poisoning is treated by removal from exposure and supportive care. If ingested, induced vomiting or gastric lavage may be performed. (A7, L139)
2009-03-06T18:58:35Z
2014-12-24T20:21:38Z
Metallothionein-2 (P02795)
Metallothionein-1G (P13640)
Metallothionein-1H (P80294)
Metallothionein-3 (P25713)
Metallothionein-1F (P04733)
Metallothionein-1E (P04732)
Metallothionein-1X (P80297)
Metallothionein-1A (P04731)
Metallothionein-1B (P07438)
Metallothionein-1M (Q8N339)
Metallothionein-4 (P47944)
Metallothionein-1L (Q93083)
Catalase (P04040)
Hemoglobin subunit alpha (P69905)
Hemoglobin subunit beta (P68871)
Hemoglobin subunit gamma-1 (P69891)
Hemoglobin subunit gamma-2 (P69892)
Hemoglobin subunit delta (P02042)
Hemoglobin subunit epsilon (P02100)
Hemoglobin subunit theta-1 (P09105)
Hemoglobin subunit zeta (P02008)
Hemoglobin subunit mu (Q6B0K9)
Serum albumin (P02768)
(L6, L7, L92)
C104191
Mercury cadmium telluride
true
Catalase (P04040)
(L7, L92)
Metallothionein-2 (P02795)
Metallothionein-1G (P13640)
Metallothionein-1H (P80294)
Metallothionein-3 (P25713)
Metallothionein-1F (P04733)
Metallothionein-1E (P04732)
Metallothionein-1X (P80297)
Metallothionein-1A (P04731)
Metallothionein-1B (P07438)
Metallothionein-1M (Q8N339)
Metallothionein-4 (P47944)
Metallothionein-1L (Q93083)
Hemoglobin subunit alpha (P69905)
Hemoglobin subunit beta (P68871)
Hemoglobin subunit gamma-1 (P69891)
Hemoglobin subunit gamma-2 (P69892)
Hemoglobin subunit delta (P02042)
Hemoglobin subunit epsilon (P02100)
Hemoglobin subunit theta-1 (P09105)
Hemoglobin subunit zeta (P02008)
Hemoglobin subunit mu (Q6B0K9)
Serum albumin (P02768)
(L6, L7, L92)
[Cd]=[Te]=[Hg]
CdHgTe
InChI=1S/Cd.Hg.Te
InChIKey=MCMSPRNYOJJPIZ-UHFFFAOYSA-N
440.6
445.780206478
Exogenous
Solid
85199