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Record Information
Version2.0
Creation Date2009-03-27 01:24:19 UTC
Update Date2014-12-24 20:22:43 UTC
Accession NumberT3D0738
Identification
Common NameZinc phosphate
ClassSmall Molecule
DescriptionZinc phosphate is a phosphate of zinc. It is found naturally as the minerals hopeite, parahopeite, and tarbuttite. Zinc phosphate is used as a dental cement and corrosion resistant coating. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (2, 3, 4) Zinc phosphate (Zn3(PO4)2) is an inorganic chemical compound used as a corrosion resistant coating on metal surfaces either as part of an electroplating process or applied as a primer pigment (see also red lead). Zinc phosphate coats better on a crystalline structure than bare metal, so a seeding agent is often used as a pre-treatment. One common agent is sodium pyrophosphate.
Compound Type
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Natural Compound
  • Zinc Compound
Chemical Structure
Thumb
Synonyms
Synonym
Bonderite 181
Bonderite 40
Bonderite 880
C.I. Pigment White 32
Delaphos
Delaphos 2M
Fleck's extraordinary
Fleck's extraordinary cement
Granodine 80
Heucophos ZP 10
LF Bowsei PW 2
LF-PW 2
Microphos 90
Neutral zinc phosphate
Phosphinox PZ 06
Phosphoric acid, zinc salt
Pigment White 32
Sicor ZNP/m
Sicor ZNP/s
Tribasic zinc phosphate
Trizinc bis(orthophosphate)
Trizinc diphosphate
Virchem 931
Weather coat 1000
Zinc acid phosphate
Zinc hydrogen phosphate
Zinc ortho-phosphate
Zinc orthophosphate
Zinc phosphate (3:2)
Zinc phosphate cement
Zinc phosphic acid
Zn3(PO4)2
ZP-DL
ZP-SB
ZPF
Chemical FormulaO8P2Zn3
Average Molecular Mass386.170 g/mol
Monoisotopic Mass381.694 g/mol
CAS Registry Number7779-90-0
IUPAC Nametrizinc(2+) ion diphosphate
Traditional Nametrizinc(2+) ion diphosphate
SMILES[Zn++].[Zn++].[Zn++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O
InChI IdentifierInChI=1S/2H3O4P.3Zn/c2*1-5(2,3)4;;;/h2*(H3,1,2,3,4);;;/q;;3*+2/p-6
InChI KeyInChIKey=LRXTYHSAJDENHV-UHFFFAOYSA-H
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as transition metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is a transition metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassTransition metal oxoanionic compounds
Sub ClassTransition metal phosphates
Direct ParentTransition metal phosphates
Alternative Parents
Substituents
  • Transition metal phosphate
  • Inorganic oxide
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Actin Cytoskeleton
  • Cell surface
  • Cytoplasm
  • Cytosol
  • Early endosome
  • Endocytic Vesicle
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Late endosome
  • Lysosome
  • Membrane Fraction
  • Microsome
  • Microtubule
  • Mitochondrion
  • Nuclear Matrix
  • Plasma Membrane
  • Ribosome
  • Secretory vesicle
  • Soluble Fraction
  • Synaptic Vesicle
  • Tubulin
Biofluid LocationsNot Available
Tissue LocationsNot Available
Pathways
NameSMPDB LinkKEGG Link
ApoptosisNot Availablemap04210
Pentose Phosphate PathwaySMP00031 map00030
Nucleotide Excision RepairSMP00478 map03420
EndocytosisNot Availablemap04144
Rna degradationNot Availablemap03018
Osteoclast differentiationNot Availablemap04380
Mineral absorptionNot Availablemap04978
Galactose MetabolismSMP00043 map00052
Circadian rhythmNot Availablemap04710
Cell cycleNot Availablemap04110
TetracyclinesNot AvailableNot Available
Starch and Sucrose MetabolismSMP00058 map00500
ProteasomeNot AvailableNot Available
Pentose and glucuronate interconversionsNot Availablemap00040
Carbon MetabolismNot AvailableNot Available
Ascorbate and aldarate metabolismNot Availablemap00053
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite crystals.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
LogPNot Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area86.25 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.29 m³·mol⁻¹ChemAxon
Polarizability4.93 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0009000000-9f11118be028a37a4e05JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-0009000000-9f11118be028a37a4e05JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-0009000000-9f11118be028a37a4e05JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-0009000000-39586e13b1f2e1038a8bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-0009000000-39586e13b1f2e1038a8bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-0009000000-39586e13b1f2e1038a8bJSpectraViewer
Toxicity Profile
Route of ExposureInhalation (3) ; oral (3) ; dermal (3)
Mechanism of ToxicityAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)
MetabolismZinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (3)
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesZinc phosphate is used as a dental cement and corrosion resistant coating. (4)
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (6) Chronic Oral: 0.3 mg/kg/day (6)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (3)
SymptomsIngestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound ID24519
ChEMBL IDCHEMBL2286756
ChemSpider ID22927
KEGG IDNot Available
UniProt IDNot Available
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDZinc phosphate
PDB IDNot Available
ACToR ID12190
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDST3D0738.pdf
General References
  1. Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322. [19021549 ]
  2. Wikipedia. Zinc. Last Updated 24 March 2009. [Link]
  3. ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for zinc. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
  4. Wikipedia. Zinc phosphate. Last Updated 16 March 2009. [Link]
  5. Wikipedia. Metallothionein. Last Updated 20 December 2008. [Link]
  6. ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

General Function:
Zinc ion binding
Specific Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name:
SOD1
Uniprot ID:
P00441
Molecular Weight:
15935.685 Da
References
  1. Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322. [19021549 ]