785
T3D0784
1,3,5-Trichlorobenzene
1,3,5-Trichlorobenzene is an organochloride aromatic compound and one of the three isomeric forms of trichlorobenzene. Trichlorobenzene is used as a solvent. (L223)
108-70-3
7950
C6H3Cl3
179.930030
White crystals.
63.5°C
0.00601 mg/mL at 25°C [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Inhalation (T38) ; oral (T38) ; dermal (T38)
Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalently bind to cellular proteins and alkylate DNA. (A154, A155)
Trichlorobenzene is absorbed via oral, inhalation, and dermal routes. It is believed to be metabolized via cytochrom p-450 enzymes into metabolites that include phenols, mercapturic acid, and catechols.(T38)
No indication of carcinogenicity to humans (not listed by IARC).
Trichlorobenzene is used as a solvent in chemical manufacturing, as well as in dyes, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium, and insecticides. (T39)
High levels of trichlorobenzene may damage the liver, kidney, and thyroid. (A153)
Trichlorobenzene irritates the eyes and respiratory tract. (T20)
2009-05-26T20:29:59Z
2014-12-24T20:22:49Z
49916
DIHYDRO-DIOH-BENZOATE
1,3,5-Trichlorobenzene
DB03836
6736
true
ClC1=CC(Cl)=CC(Cl)=C1
C6H3Cl3
InChI=1S/C6H3Cl3/c7-4-1-5(8)3-6(9)2-4/h1-3H
InChIKey=XKEFYDZQGKAQCN-UHFFFAOYSA-N
181.447
179.930033217
Exogenous
Solid
CHEMBL44228
7662