Record Information |
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Version | 2.0 |
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Creation Date | 2009-06-18 17:03:34 UTC |
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Update Date | 2014-12-24 20:23:03 UTC |
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Accession Number | T3D1026 |
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Identification |
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Common Name | Phenothrin |
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Class | Small Molecule |
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Description | Phenothrin, also called sumithrin, is a synthetic pyrethroid (type 1) that kills adult fleas and ticks. It has also been used to kill head lice in humans. d-phenothrin is used as a component of aerosol insecticides for domestic use. Phenothrin is often used with methoprene, an insect growth regulator that interrupts the insect's biological life cycle by killing the eggs. In 2005, the EPA required Hartz Mountain Industries to cancel uses of several flea and tick products containing phenothrin that were linked to a range of adverse reactions, including hair loss, salivation, tremors, and numerous deaths in cats and kittens. In the short term, the agreement called for new warning labels on the products. A pyrethroid is a synthetic chemical compound similar to the natural chemical pyrethrins produced by the flowers of pyrethrums (Chrysanthemum cinerariaefolium and C. coccineum). Pyrethroids are common in commercial products such as household insecticides and insect repellents. In the concentrations used in such products, they are generally harmless to human beings but can harm sensitive individuals. They are usually broken apart by sunlight and the atmosphere in one or two days, and do not significantly affect groundwater quality except for being toxic to fish. (9, 11) |
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Compound Type | - Ester
- Ether
- Household Toxin
- Organic Compound
- Pesticide
- Pyrethroid
- Synthetic Compound
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Chemical Structure | |
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Synonyms | Synonym | (+)-Cis-fenothrin | (+/-)-phenoxybenzyl-cis,trans-chrysanthemate | (-)-Trans-phenothrin | 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (3-phenoxyphenyl)methyl ester | 3-Phenoxybenzyl (+-)-cis-trans-chrysanthemate | 3-Phenoxybenzyl (1RS)-cis,trans-chrysanthemate | 3-Phenoxybenzyl chrysanthemate | 3-Phenoxybenzyl D-Z/E chrysanthemate | Anchimanaito 20S | Anvil | Caswell No. 652B | D-phenothrin | D-phenthrin (trans) | Delta-(cis-trans)-phenothrin | Fenothrin | Forte | Multicide 2154 | Multicide Concentrate F-2271 | phenothrin, (1R-cis)-isomer | phenothrin, (1R-trans)-isomer | phenothrin, (1S-cis)-isomer | phenothrin, (1S-trans)-isomer | Phenothrin, (cis-(+-))-isomer | Phenothrin, (trans-(+-))-isomer | Phenothrine | Phenoxybenzyl (1R)-cis/trans chrysanthemate | Phenoxybenzyl chrysanthemate | Phenoxybenzyl-d-z/e-chrysanthemate | Phenoxythrin | Phonothrin | Pibutin | S 2539 (pesticide) | Sumithrin | Sumitrin | Wellcide |
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Chemical Formula | C23H26O3 |
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Average Molecular Mass | 350.451 g/mol |
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Monoisotopic Mass | 350.188 g/mol |
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CAS Registry Number | 26002-80-2 |
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IUPAC Name | (3-phenoxyphenyl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate |
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Traditional Name | phenothrin |
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SMILES | CC(C)=CC1C(C(=O)OCC2=CC=CC(OC3=CC=CC=C3)=C2)C1(C)C |
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InChI Identifier | InChI=1S/C23H26O3/c1-16(2)13-20-21(23(20,3)4)22(24)25-15-17-9-8-12-19(14-17)26-18-10-6-5-7-11-18/h5-14,20-21H,15H2,1-4H3 |
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InChI Key | InChIKey=SBNFWQZLDJGRLK-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as pyrethroids. These are organic compounds similar to the pyrethrins. Some pyrethroids containing a chrysanthemic acid esterified with a cyclopentenone (pyrethrins), or with a phenoxybenzyl group. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Fatty Acyls |
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Sub Class | Fatty acid esters |
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Direct Parent | Pyrethroids |
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Alternative Parents | |
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Substituents | - Pyrethroid skeleton
- Diphenylether
- Diaryl ether
- Aromatic monoterpenoid
- Benzyloxycarbonyl
- Monocyclic monoterpenoid
- Monoterpenoid
- Phenoxy compound
- Phenol ether
- Monocyclic benzene moiety
- Cyclopropanecarboxylic acid or derivatives
- Benzenoid
- Carboxylic acid ester
- Ether
- Carboxylic acid derivative
- Monocarboxylic acid or derivatives
- Hydrocarbon derivative
- Organic oxygen compound
- Carbonyl group
- Organic oxide
- Organooxygen compound
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Exogenous |
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Cellular Locations | |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | |
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Biological Roles | |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Liquid |
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Appearance | Yellow to yellow-brown liquid (12). |
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Experimental Properties | Property | Value |
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Melting Point | < 25°C | Boiling Point | >290°C | Solubility | 9.7e-06 mg/mL at 25°C [TOMLIN,C (1997); <9.7 ug/L] | LogP | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | Deposition Date | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2020-08-04 | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 45V, Negative | splash10-0a4i-0009000000-40229bc9204047a90696 | 2021-09-20 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 60V, Negative | splash10-0a4i-0009000000-ef289d9b6c43e9ffbab1 | 2021-09-20 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 15V, Negative | splash10-0002-0009000000-aaf1dcdf1335b088a86b | 2021-09-20 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 30V, Negative | splash10-0a4i-0009000000-b8fdf60d2da1b9af6def | 2021-09-20 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 90V, Positive | splash10-0a6u-0900000000-c9855a3f9fc537fb0bcf | 2021-09-20 | View Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 45V, Positive | splash10-0a4l-0900000000-efa2e4a7c20189b908ea | 2021-09-20 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0udi-0409000000-29f91143368a5e163638 | 2016-08-02 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0udi-3935000000-1f5ba52cfd1331e3c829 | 2016-08-02 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0pvi-7900000000-a7c057d4e94614b05bf6 | 2016-08-02 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0002-0109000000-2146ad06bc95b25bf442 | 2016-08-03 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0002-2809000000-986cbdb101e42868e61b | 2016-08-03 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-9400000000-8f041a7fa0db67d9ea24 | 2016-08-03 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0f7k-2794000000-e3308d4427a553ee9e33 | 2021-10-12 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-001i-2913000000-92692d151e0539f88ca0 | 2021-10-12 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-001i-7900000000-c59f160f7452c1b7d545 | 2021-10-12 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0002-0309000000-1a857626b5331003790e | 2021-10-12 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00di-0901000000-e1b9792b83ff015d64f7 | 2021-10-12 | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-9322000000-254c9ac19a5f51b0b4b2 | 2021-10-12 | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-00e9-5900000000-82828ceb9c78ca715405 | 2014-09-20 | View Spectrum |
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Toxicity Profile |
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Route of Exposure | Inhalation (10); oral (10); dermal (10) ; eye contact (10). |
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Mechanism of Toxicity | Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase in the immediate vicinity of the sodium channel, thus modifying the channel kinetics. This blocks the closing of the sodium gates in the nerves, and thus prolongs the return of the membrane potential to its resting state. The repetitive (sensory, motor) neuronal discharge and a prolonged negative afterpotential produces effects quite similar to those produced by DDT, leading to hyperactivity of the nervous system which can result in paralysis and/or death. Other mechanisms of action of pyrethroids include antagonism of gamma-aminobutyric acid (GABA)-mediated inhibition, modulation of nicotinic cholinergic transmission, enhancement of noradrenaline release, and actions on calcium ions. They also inhibit calium channels and Ca2+, Mg2+-ATPase. (5, 6, 10) |
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Metabolism | d-Phenothrin is a fast acting insecticide, effective by contact and stomach action. It is rapidly metabolized and excreted by humans and has low human toxicity. For both cis- and trans- isomers, the product was metabolized by hydrolysis, oxidation and conjugation and a large part of d-Phenothrin is excreted unchanged in the urine and the faeces. Following oral administration of the (1R)- trans - isomer, the urine is the major excretory route. The isomer is extensively metabolized to oxidative and conjugated derivatives of the hydrolysed ester. Oxidative and conjugated derivatives of the
(1R)- cis -isomer are also observed but hydrolysis of the ester linkage is a minor metabolic pathway. With this isomer the faeces is the major excretory route. The metabolic profiles aree similar following dermal application, although the rates of excretion for each isomer showed some differences between the two routes of administration. The major metabolite is 3-phenoxybenzyl alcohol (PBalc). Smaller amounts of PBacid and trace amounts of 4'-OH-PBacid are also found. It is stable to storage in the dark; d-Phenothrin is relatively unstable to sunlight or ultra violet irradiation, or in alkaline media. (12, 3) |
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Toxicity Values | LD50: > 5000 mg/kg (Oral, Rat) (3)
LD50: 10 000 mg/kg (Dermal, Rat) (3) |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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Uses/Sources | Pyrethroids are used as insecticides. (10) |
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Minimum Risk Level | Not Available |
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Health Effects | Pyrethroid effects typically include rapid onset of aggressive behavior and increased sensitivity to external stimuli, followed by fine tremor, prostration with coarse whole body tremor, elevated body temperature, coma, and death. Paresthesia, severe corneal damage, hypotension and tachycardia, associated with anaphylaxis, can also occur following pyrethriod poisoning. (10) |
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Symptoms | Following oral exposure, severe fine tremor, marked reflex hyperexcitability, sympathetic activation can occur. Nausea, vomiting and abdominal pain commonly occur and develop following ingestion. Sudden bronchospasm, swelling of oral and laryngeal mucous membranes, and anaphylactoid reactions have been reported after inhalation. Hypersensitivity reactions characterized by pneumonitis, cough, dyspnea, wheezing, chest pain, and bronchospasm may occur too . Dermatitis is the main effect of a dermal exposure to phenothrin. (7) |
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Treatment | Following oral exposure, the treatment is symptomatic and supportive and includes monitoring for the development of hypersensitivity reactions with respiratory distress. Provide adequate airway management when needed. Gastric decontamination is usually not required unless the pyrethrin product is combined with a hydrocarbon. Following inhalation exposure, move patient to fresh air. monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. If the contamination occurs through dermal exposure, Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. Vitamin E topical application is highly effective in relieving parenthesis. (13) |
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Normal Concentrations |
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| Not Available |
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Abnormal Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | Not Available |
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PubChem Compound ID | 4767 |
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ChEMBL ID | CHEMBL1322884 |
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ChemSpider ID | 4603 |
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KEGG ID | C14387 |
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UniProt ID | Not Available |
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OMIM ID | |
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ChEBI ID | 34916 |
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BioCyc ID | Not Available |
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CTD ID | C006166 |
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Stitch ID | Phenothrin |
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PDB ID | Not Available |
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ACToR ID | 13208 |
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Wikipedia Link | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | T3D1026.pdf |
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General References | - Brody SA, Loriaux DL: Epidemic of gynecomastia among haitian refugees: exposure to an environmental antiandrogen. Endocr Pract. 2003 Sep-Oct;9(5):370-5. [14583418 ]
- Scollon EJ, Starr JM, Godin SJ, DeVito MJ, Hughes MF: In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms. Drug Metab Dispos. 2009 Jan;37(1):221-8. doi: 10.1124/dmd.108.022343. Epub 2008 Oct 23. [18948380 ]
- Suruga K, Kitagawa M, Yasutake H, Takase S, Goda T: Diet-related variation in cellular retinol-binding protein type II gene expression in rat jejunum. Br J Nutr. 2005 Dec;94(6):890-5. [16351764 ]
- Leng G, Lewalter J, Rohrig B, Idel H: The influence of individual susceptibility in pyrethroid exposure. Toxicol Lett. 1999 Jun 30;107(1-3):123-30. [10414789 ]
- Casarett LJ, Klaassen CD, and Watkins JB (2003). Casarett and Doull's essentials of toxicology. New York: McGraw-Hill/Medical Pub. Div.
- Hayes WJ Jr. and Laws ER Jr. (eds) (1991). Handbook of Pesticide Toxicology. Volume 3. Classes of Pesticides. New York, NY: Academic Press, Inc.
- Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009.
- WHO (1990). Environmental Health Criteria 96: Phenothrin.
- Wikipedia. Pyrethroid. Last Updated 8 June 2009. [Link]
- ATSDR - Agency for Toxic Substances and Disease Registry (2003). Toxicological profile for pyrethrins and pyrethroids. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). [Link]
- Wikipedia. Phenothrin. Last Updated 1 August 2009. [Link]
- International Programme on Chemical Safety (IPCS) INCHEM (1994). Pesticide Document for D-phenothrin. [Link]
- Wikipedia. Blister agent. Last Updated 24 May 2009. [Link]
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Gene Regulation |
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Up-Regulated Genes | Gene | Gene Symbol | Gene ID | Interaction | Chromosome | Details |
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Down-Regulated Genes | Not Available |
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