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Record Information
Version2.0
Creation Date2009-07-03 22:18:59 UTC
Update Date2014-12-24 20:25:37 UTC
Accession NumberT3D2495
Identification
Common NameAtracotoxin, omega- (Hadronyche versuta)
ClassProtein
DescriptionAtracotoxins are a peptide toxins produced by funnel web spiders (family Hexathelidae). omega-Atracotoxins inhibit invertebrate voltage-gated calcium channel currents. (1, 3)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Spider Toxin
Protein StructureT3d2495
Synonyms
Synonym
omega-ACTX- HV1
Omega-atracotoxin
omega-atracotoxin-HV1
Chemical FormulaNot Available
Average Molecular Mass4055.410 g/mol
CAS Registry Number193981-10-1
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Toxicity Profile
Route of ExposureInjection (sting/bite) (3)
Mechanism of Toxicityomega-Atracotoxins inhibit invertebrate voltage-gated calcium channel currents. (1, 3)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesAtracotoxins are a peptide toxins produced by funnel web spiders (family Hexathelidae). (3)
Minimum Risk LevelNot Available
Health EffectsDeath from funnel web spider bites can result from progressive hypotension or possibly raised intracranial pressure resulting from cerebral oedema. (2)
SymptomsThe bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (2)
TreatmentFirst aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (2)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP56207
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
PDB ID1AXH
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  2. Wikipedia. Australian funnel-web spider. Last Updated 6 July 2009. [Link]
  3. Wikipedia. Spider toxin. Last Updated 9 January 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available