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Exotoxin A (Pseudomonas aeruginosa) (T3D2607)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationTargets (1)XML
Targets (1)
Record Information
Version2.0
Creation Date2009-07-06 18:11:30 UTC
Update Date2014-12-24 20:25:46 UTC
Accession NumberT3D2607
Identification
Common NameExotoxin A (Pseudomonas aeruginosa)
ClassProtein
DescriptionPseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. (2)
Compound Type
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureT3d2607
Synonyms
Synonym
ETA
Exotoxin A
NAD(+)--diphthamide ADP-ribosyltransferase
Chemical FormulaNot Available
Average Molecular Mass69283.345 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureIngestion (4) ; inhalation (4) ; dermal (4)
Mechanism of ToxicityPseudomonas exotoxin has exactly the same mechanism of action as the diphtheria toxin; it causes the ADP ribosylation of eucaryotic elongation factor 2 resulting in inhibition of protein synthesis in the affected cell. Although it is partially-identical to diphtheria toxin, it is antigenically-distinct. It utilizes a different receptor on host cells than diphtheria toxin, but otherwise it enters cells in the same manner and has the exact enzymatic mechanism. (3)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesLD50: 3 ug/mg (Intravenous, Mouse) (1)
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesPseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. (2)
Minimum Risk LevelNot Available
Health EffectsPseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Pseudomonas aeruginosa can infect damaged tissues or people with reduced immunity. If such colonisations occur in critical body organs such as the lungs, the urinary tract, and kidneys, the results can be fatal. (2)
SymptomsPseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Pseudomonas aeruginosa can infect damaged tissues or people with reduced immunity. The symptoms of such infections are generalised inflammation and sepsis. (2)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP11439
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDPseudomonas exotoxin
PDB ID1AER
ACToR IDNot Available
Wikipedia LinkPseudomonas_exotoxin
References
Synthesis ReferenceNot Available
MSDST3D2607.pdf
General References
  1. Gill DM: Bacterial toxins: a table of lethal amounts. Microbiol Rev. 1982 Mar;46(1):86-94. [6806598 ]
  2. Wikipedia. Pseudomonas exotoxin. Last Updated 30 May 2009. [Link]
  3. Wikipedia. Pseudomonas aeruginosa. Last Updated 8 August 2009. [Link]
  4. Wikipedia. Bacterial toxin. Last Updated 27 February 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

Target Details
1. Elongation factor 2
General Function:
Translation elongation factor activity
Specific Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Gene Name:
EEF2
Uniprot ID:
P13639
Molecular Weight:
95337.385 Da
References
  1. Wikipedia. Pseudomonas aeruginosa. Last Updated 8 August 2009. [Link]