Record Information
Version2.0 (beta)
Creation Date2009-07-06 15:35:33 -0600
Update Date2014-09-12 16:38:03 -0600
Accession NumberT3D2631
Identification
Common NameHeteroscodratoxin
ClassProtein
DescriptionHeteroscodratoxin is a peptide toxin produced by the Togo starburst tarantula (Heteroscodra maculata). It inhibits voltage-gated potassium channels. (1)
Compound Type
  • Organic Compound
  • Spider Toxin
  • Protein
Protein StructureNo structure small
SynonymsNot Available
Chemical FormulaNot Available
Average Molecular Weight4003.3999999999996 g/mol
CAS Registry NumberNot Available
Sequence
>Heteroscodratoxin
ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
Chemical Taxonomy
KingdomNot Available
Super ClassNot Available
ClassNot Available
Sub ClassNot Available
Direct ParentNot Available
Alternative ParentsNot Available
SubstituentsNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected but not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
LogPNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Route of ExposureInjection (sting/bite) (2)
Mechanism of ToxicityHeteroscodratoxin inhibits voltage-gated potassium channels by binding to the extracellular linker of the channel and shifting activation of the channel to more depolarized voltages. (1)
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesHeteroscodratoxin is a peptide toxin produced by the Togo starburst tarantula (Heteroscodra maculata). (1)
Minimum Risk LevelNot Available
Health EffectsHeteroscodratoxin is neurotoxic. (1)
SymptomsHeteroscodratoxin may cause convulsions, spasms, tremors, and death. (1)
TreatmentNot Available
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP60992
OMIM IDNot Available
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDHeteroscodratoxin
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  2. Wikipedia. Spider toxin. Last Updated 9 January 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q14721
Molecular weight:
Not Available
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q92953
Molecular weight:
Not Available
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q9NSA2
Molecular weight:
Not Available
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
General function:
Inorganic ion transport and metabolism
Specific function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits
Gene Name:
KCND2
Uniprot ID:
Q9NZV8
Molecular weight:
70535.8
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
General function:
Inorganic ion transport and metabolism
Specific function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits
Gene Name:
KCND3
Uniprot ID:
Q9UK17
Molecular weight:
73450.5
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.