omega-Conotoxin (Conus striatus) (T3D2656)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationTargets (1)XML
Targets (1)
Record Information
Version2.0
Creation Date2009-07-07 21:54:31 UTC
Update Date2014-12-24 20:25:48 UTC
Accession NumberT3D2656
Identification
Common Nameomega-Conotoxin (Conus striatus)
ClassProtein
DescriptionConotoxins are neurotoxic peptides from the venom of the marine cone snail (genus Conus). omega-Conotoxins inhibit N-type voltage-dependent calcium channels and have an analgesic effect. (1)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Snail Toxin
Protein StructureT3d2656
Synonyms
Synonym
omega-Conotoxin
Omega-conotoxin SVIA
w-Conotoxin
Chemical FormulaNot Available
Average Molecular Mass7628.040 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (2)
Mechanism of Toxicityomega-Conotoxins act at presynaptic membranes, where they bind inhibit N-type voltage-dependent calcium channels. (1)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesConotoxins are neurotoxic peptides from the venom of the marine cone snail (genus Conus). (1)
Minimum Risk LevelNot Available
Health EffectsConotoxins are neurotoxic. (1)
SymptomsCone snail stings can cause intense pain, swelling, numbness and tingling. Symptoms can start immediately or can be delayed in onset for days. Severe cases involve muscle paralysis, changes in vision and respiratory failure that can lead to death. (3)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDQ9XZK2
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDConotoxin, omega-
PDB ID1FYG
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Wikipedia. Conotoxin. Last Updated 2 June 2009. [Link]
  2. Wikipedia. Mollusca. Last Updated 5 August 2009. [Link]
  3. Wikipedia. Cone snail. Last Updated 29 July 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

Target Details
1. Voltage-dependent N-type calcium channel subunit alpha-1B
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Gene Name:
CACNA1B
Uniprot ID:
Q00975
Molecular Weight:
262493.84 Da
References
  1. Wikipedia. Conotoxin. Last Updated 2 June 2009. [Link]