2815
T3D2773
Procyclidine
Procyclidine is only found in individuals that have used or taken this drug. It is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation.
77-37-2
4919
C19H29NO
287.224920
White powder.
86°C
Moderately soluble in water, ~ 30 mg/ml
Oral
The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation.
LD<sub>50</sub>=60 mg/kg (IV in mice)
No indication of carcinogenicity to humans (not listed by IARC).
For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
LD<sub>50</sub>=60 mg/kg (IV in mice)
2009-07-21T20:26:46Z
2014-12-24T20:25:51Z
Procyclidine
C07378
8448
Procyclidine
DB00387
true
OC(CCN1CCCC1)(C1CCCCC1)C1=CC=CC=C1
C19H29NO
InChI=1/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
InChIKey=WYDUSKDSKCASEF-UHFFFAOYNA-N
287.4397
287.224914555
Exogenous
Solid
4.2
HMDB14531
CHEMBL86715
4750