2892
T3D2850
Pentazocine
Pentazocine is only found in individuals that have used or taken this drug. It is the first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)The preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor.
359-83-1
441278
C19H27NO
285.209260
White powder.
146.3°C
1.22e-01 g/L
Intravenous, Oral. Well absorbed from the gastro-intestinal tract.
The preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor.
Hepatic
Half Life: 2 to 3 hours
No indication of carcinogenicity to humans (not listed by IARC).
Used to treat mild to moderately severe pain. [Wikipedia]
Medical problems can include congested lungs, liver disease, tetanus, cardiovascular effects, infection of the heart valves, skin abscesses, anemia and pneumonia. Death can occur from overdose.
hallucinations and other psychotomimetic effects; cardiovascular effects
Adequate measures to maintain ventilation and general circulatory support should be employed. Assisted or controlled ventilation, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Consideration should be given to gastric lavage and gastric aspiration. For respiratory depression due to overdosage or unusual sensitivity to pentazocine, parenteral naloxone is a specific and effective antagonist. Initial doses of 0.4 to 2.0 mg of naloxone are recommended, repeated at 2-3 minute intervals, if needed, up to a total of 10 mg. Anti
2009-07-21T20:27:20Z
2014-12-24T20:25:52Z
Pentazocine
C07421
116117
Pentazocine
DB00652
true
[H][C@]12CC3=C(C=C(O)C=C3)[C@](C)(CCN1CC=C(C)C)[C@@]2([H])C
C19H27NO
InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
InChIKey=VOKSWYLNZZRQPF-GDIGMMSISA-N
285.4238
285.209264491
Exogenous
Solid
4.64
HMDB14790
CHEMBL560
390041