3062
T3D3020
Mitoxantrone
Mitoxantrone is only found in individuals that have used or taken this drug. It is an anthracenedione-derived antineoplastic agent. Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
65271-80-9
4212
C22H28N4O6
444.200890
7.34e-01 g/L
Intravenous injection. Poorly absorbed following oral administration.
Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Hepatic
Half Life: 75 hours
2B, possibly carcinogenic to humans. (L135)
For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an Anthracenedione (not an anthracycline) antineoplastic agent.
Cardiomyopathy is a particularly concerning effect as it is irreversible. [Wikipedia]
Severe leukopenia with infection.
2009-07-21T20:28:38Z
2014-12-24T20:25:55Z
Mitoxantrone
C11195
50729
Mitoxantrone
DB01204
MIX
true
OCCNCCNC1=C2C(=O)C3=C(O)C=CC(O)=C3C(=O)C2=C(NCCNCCO)C=C1
C22H28N4O6
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N
444.4809
444.200884648
Exogenous
Liquid
-3.1
HMDB15335
CHEMBL58
4067
<p><a href="http://www.drugsyn.org/Mitoxantrone.htm">DrugSyn.org</a></p>