3123
T3D3081
(-)-Gossypol
(-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton).
(-)-gossypol has been shown to exhibit anti-tumor, anti-cancer and anti-proliferative functions (A7832, A7833, A7834).
90141-22-3
3503
C30H30O8
518.194070
White powder.
178 - 183°C
Oral (ingestion) (L1817) ; dermal (L1817)
Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind calmodulin. (L1239)
No indication of carcinogenicity to humans (not listed by IARC).
Gossypol is a plant toxin found in the cotton plant (genus Gossypium, family Malvaceae). Among other things, it has been tested as a male oral contraceptive in China. In addition to its contraceptive properties, gossypol has also long been known to possess anti-malarial properties. (L1239)
Gossypol may cause low potassium levels and thus causes temporary paralysis. (L1239)
Symptoms of gossypol poisoning include fatigue, muscle weakness, and at its most extreme, paralysis. (L1239)
2009-07-23T18:26:07Z
2014-12-24T20:25:57Z
C07667
25520
Gossypol
true
CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(O)=C1O)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C
C30H30O8
InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
InChIKey=QBKSWRVVCFFDOT-UHFFFAOYSA-N
518.5544
518.194067936
Exogenous
Solid
HMDB40723
3383