You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Toxin, Toxin Target Database.
Record Information
Version2.0
Creation Date2009-07-23 18:26:17 UTC
Update Date2014-12-24 20:25:58 UTC
Accession NumberT3D3101
Identification
Common NameBrodifacoum
ClassSmall Molecule
DescriptionBrodifacoum is a highly lethal anticoagulant poison derived from coumarin. It is typically used as a rodenticide but is also used to control larger mammalian pests. (2)
Compound Type
  • Aromatic Hydrocarbon
  • Bromide Compound
  • Ester
  • Household Toxin
  • Organic Compound
  • Organobromide
  • Pesticide
  • Synthetic Compound
Chemical Structure
Thumb
Synonyms
Synonym
BFC
Brodifakum
Bromfenacoum
Klerat
Ratak
Super warfarin
Superwarfarin
Talon
Talon rodenticide
Talon-g
Volid
Chemical FormulaC31H23BrO3
Average Molecular Mass523.417 g/mol
Monoisotopic Mass522.083 g/mol
CAS Registry Number56073-10-0
IUPAC Name3-{3-[4-(4-bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl}-2-hydroxy-4H-chromen-4-one
Traditional Namebrodifacoum
SMILESOC1=C(C2CC(CC3=CC=CC=C23)C2=CC=C(C=C2)C2=CC=C(Br)C=C2)C(=O)C2=CC=CC=C2O1
InChI IdentifierInChI=1S/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,34H,17-18H2
InChI KeyInChIKey=LNDUTAIPEYOCDF-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as phenylnaphthalenes. These are compounds containing a phenylnaphthalene skeleton, which consists of a naphthalene bound to a phenyl group.
KingdomChemical entities
Super ClassOrganic compounds
ClassBenzenoids
Sub ClassNaphthalenes
Direct ParentPhenylnaphthalenes
Alternative Parents
Substituents
  • Phenylnaphthalene
  • Brominated biphenyl
  • Biphenyl
  • Chromone
  • Coumarin
  • Benzopyran
  • 1-benzopyran
  • Tetralin
  • Bromobenzene
  • Pyranone
  • Halobenzene
  • Aryl bromide
  • Aryl halide
  • Monocyclic benzene moiety
  • Pyran
  • Heteroaromatic compound
  • Vinylogous acid
  • Organoheterocyclic compound
  • Oxacycle
  • Organooxygen compound
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organobromide
  • Organohalogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Membrane
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point230°C
Boiling PointNot Available
Solubility3.8e-06 mg/mL at 20°C [TOMLIN,C (1997); pH 5.2]
LogPNot Available
Predicted Properties
PropertyValueSource
Water Solubility4.56e-05 mg/mLALOGPS
logP7.63ALOGPS
logP8.4ChemAxon
logS-7.1ALOGPS
pKa (Strongest Acidic)8.19ChemAxon
pKa (Strongest Basic)-5.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity151.41 m3·mol-1ChemAxon
Polarizability54.48 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0011090000-85319378506888ebe218View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0axr-0476290000-efaf2111f7eb8e658f10View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-05i0-0962220000-6dce943e76b9c5f2bcd2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00b9-0000960000-cf53f8b648a6cddc4605View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-0300940000-db8a0ec324f2389e0308View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-8529800000-634fce5b94ab2e593c2cView in MoNA
Toxicity Profile
Route of ExposureOral (ingestion) (3) ; dermal (3)
Mechanism of ToxicityBrodifacoum inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so brodifacoum steadily decreases the level of active vitamin K in the blood. Vitamin K is required for the synthesis of important substances including prothrombin, which is involved in blood clotting. This disruption becomes increasingly severe until the blood effectively loses any ability to clot. In addition, brodifacoum increases permeability of blood capillaries. The blood plasma and blood itself begins to leak from the blood vessels, causing internal bleeding leading to shock, loss of consciousness, and eventually death. (2)
MetabolismNot Available
Toxicity ValuesLD50: 0.4 mg/kg (Oral, Mouse) (1)
Lethal Dose15 mg for an adult human. (2)
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesBrodifacoum is a highly lethal anticoagulant poison used as a pesticide. It is typically used as a rodenticide but is also used to control larger mammalian pests. (2)
Minimum Risk LevelNot Available
Health EffectsBrodifacoum is an anticoagulant and causes internal bleeding, leading to shock, loss of consciousness, and eventually death. (2)
SymptomsBrodifacoum initially causes dehydration before progressing to bleeding complications. (2)
TreatmentThe primary antidote to brodifacoum poisoning is immediate administration of vitamin K1 (initially slow intravenous injections of 10-25 mg repeated all 3-6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the poisoning is caught before too much damage has been done to the victim's circulatory system. At high doses brodifacoum can affect the body for many months, and the antidote must be administered regularly for a long period of time. (2)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound ID41736
ChEMBL IDNot Available
ChemSpider ID38082
KEGG IDNot Available
UniProt IDNot Available
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDBrodifacoum
PDB IDNot Available
ACToR ID13976
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDST3D3101.pdf
General References
  1. Tomlin CDS (ed) (1994). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council.
  2. Wikipedia. Brodifacoum. Last Updated 22 June 2009. [Link]
  3. Wikipedia. Phytotoxin. Last Updated 7 August 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

General Function:
Vitamin-k-epoxide reductase (warfarin-sensitive) activity
Specific Function:
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Gene Name:
VKORC1
Uniprot ID:
Q9BQB6
Molecular Weight:
18234.3 Da
References
  1. Wikipedia. Brodifacoum. Last Updated 22 June 2009. [Link]