3144
T3D3102
Bromadiolone
Bromadiolone is a potent anticoagulant and rodenticide. It is a second-generation coumarin derivative, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism. (L1258)
28772-56-7
34322
C30H23BrO4
526.077970
White powder.
205°C
0.019 mg/mL at 20°C [TOMLIN,C (1997)]
Oral (ingestion) (L1817) ; dermal (L1817)
Bromadiolone inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so bromadiolone steadily decreases the level of active vitamin K in the blood. Vitamin K is required for the synthesis of important substances including prothrombin, which is involved in blood clotting. This disruption becomes increasingly severe until the blood effectively loses any ability to clot. In addition, bromadiolone increases permeability of blood capillaries. The blood plasma and blood itself begins to leak from the blood vessels, causing internal bleeding leading to shock, loss of consciousness, and eventually death. (L1257)
LD50: 1.75 mg/kg (Oral, Mouse) (T66)
No indication of carcinogenicity to humans (not listed by IARC).
Bromadiolone is a potent rodenticide. (L1258)
Bromadiolone is an anticoagulant and causes internal bleeding, leading to shock, loss of consciousness, and eventually death. (L1257)
Bromadiolone initially causes dehydration before progressing to bleeding complications. (L1257)
The primary antidote to bromadiolone poisoning is immediate administration of vitamin K1 (initially slow intravenous injections of 10-25 mg repeated all 3-6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the poisoning is caught before too much damage has been done to the victim's circulatory system. At high doses bromadiolone can affect the body for many months, and the antidote must be administered regularly for a long period of time. (L1257)
2009-07-23T18:26:17Z
2014-12-24T20:25:59Z
Bromadiolone
13321
true
OC(CC(C1=CC=CC=C1)C1=C(O)OC2=CC=CC=C2C1=O)C1=CC=C(C=C1)C1=CC=C(Br)C=C1
C30H23BrO4
InChI=1S/C30H23BrO4/c31-23-16-14-20(15-17-23)19-10-12-22(13-11-19)26(32)18-25(21-6-2-1-3-7-21)28-29(33)24-8-4-5-9-27(24)35-30(28)34/h1-17,25-26,32,34H,18H2
InChIKey=IUZFQERQUZLNKQ-UHFFFAOYSA-N
527.405
526.077971871
Exogenous
Solid
31618