3568
T3D3526
Pentamidine
Pentamidine is only found in individuals that have used or taken this drug. It is an antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem] The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
100-33-4
4735
C19H24N4O2
340.189930
White powder.
186.0°C (decomposes)
Complete
Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Hepatic.
Half Life: 9.1-13.2 hours
No indication of carcinogenicity to humans (not listed by IARC).
For the treatment of pneumonia due to <i>Pneumocystis carinii</i>.
Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
2009-07-30T17:59:04Z
2014-12-24T20:26:07Z
Pentamidine
C07420
45081
Pentamidine
DB00738
PNT
true
NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1
C19H24N4O2
InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N
340.4195
340.189926032
Exogenous
Solid
4
HMDB14876
CHEMBL55
4573