4239
T3D4185
Ethylamine
Ethylamine is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
Ethylamine is a simple aliphatic amine. It is component of normal human urine it has been suggested that this short chain aliphatic chain play significant role in the central nervous system disturbances observe during hepatic and renal disease especially when the blood brain barrier is compromised. (A3299).
75-04-7
6341
C2H7N
-81.2°C
Endogenous, Ingestion, Dermal (contact)
Uremic toxins such as ethylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869).
Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.
No indication of carcinogenicity to humans (not listed by IARC).
Naturally produced by the body (endogenous).
Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
As a uremic toxin, this compound can cause uremic syndrome. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart can be seen in patients with uremic syndrome. Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present.
Kidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored.
2014-08-29T05:51:03Z
2014-12-24T20:26:41Z
Ethylamine
C00797
15862
NEH
true
CCN
C2H7N
InChI=1S/C2H7N/c1-2-3/h2-3H2,1H3
InChIKey=QUSNBJAOOMFDIB-UHFFFAOYSA-N
45.0837
45.057849229
Endogenous
Liquid
-0.13
HMDB13231
CHEMBL14449
6101