Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1249 | Bis(tributyltin) oxide 56-35-9 | C24H54OSn2 596.100 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 8 |
| T3D1894 | Triphenylantimony dibenzoate 57997-56-5 | C32H25O4Sb 595.300 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D4056 | Debromoaplysiatoxin 52423-28-6 | C32H48O10 592.718 g/mol |  |
| Debromoaplysiatoxin have the ability to evoke biological and biochemical responses in cells, and belong to the TPA (12-O-tetradecanoylphorbol 13-acetate) type tumor pr...more Number of Targets: 0 |
| T3D1901 | Tris(4-bromophenyl)antimony 17946-45-1 | C18H12Br3Sb 589.760 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D4695 | Etoposide 33419-42-0 | C29H32O13 588.557 g/mol |  |
| Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and ...more Number of Targets: 2 |
| T3D3762 | Janthitrem B 73561-90-7 | C37H47NO5 585.773 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 22 |
| T3D4350 | Bilirubin 635-65-4 | C33H36N4O6 584.662 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4018 | Ouabain 630-60-4 | C29H44O12 584.653 g/mol |  |
| Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of ...more Number of Targets: 6 |
| T3D3733 | Penitrem B 11076-67-8 | C37H45NO5 583.757 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 27 |
| T3D2750 | Dihydroergotamine 6190-39-2 | C33H37N5O5 583.677 g/mol |  |
| Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessel...more Number of Targets: 12 |
| T3D1766 | Tungsten(V) bromide 13470-11-6 | Br5W 583.360 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D2460 | Ergotamine 113-15-5 | C33H35N5O5 581.662 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 16 |
| T3D1758 | Tantalum(V) bromide 13451-11-1 | Br5Ta 580.468 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D3742 | Fumitremorgin A 12626-18-5 | C32H41N3O7 579.684 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 22 |
| T3D2132 | 1,2,3,4,6,7,8,9,10,10,11,11-Dodecachloro-1,4,4a,5a,6,9,9a,9b-octahydro-1,4:6,9- dimethanodibenzofuran 31107-44-5 | C14H5Cl11O 579.172 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D1897 | Triphenylcarbenium hexachloroantimonate 52704-88-8 | C19H15Cl6Sb 577.800 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1583 | Bis(1,5-diphenyl-1,4-pentadien-3-one) palladium(0) 32005-36-0 | C34H30O2Pd 577.020 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D3094 | Oleandrin 465-16-7 | C32H48O9 576.718 g/mol |  |
| Oleandrin likely exerts its toxic effects by inhibiting Na+,K+-ATPase. (A2831) Number of Targets: 9 |
| T3D1313 | Thorin 3688-92-4 | C16H11AsN2Na2O10S2 576.297 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D3690 | Ergocryptine 511-09-1 | C32H41N5O5 575.698 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 4 |
| T3D3768 | Luteoskyrin 21884-44-6 | C30H22O12 574.489 g/mol |  |
| Luteoskyrin is hepatotoxic. It is thought that this is a result of its metabolic reduction to the semiquinone radical catalyzed by NADPH-dependent cytochrome reductase...more Number of Targets: 26 |
| T3D3693 | Xanthomegnin 1685-91-2 | C30H22O12 574.489 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D1147 | Manganese phthalocyanine 14325-24-7 | C32H22MnN8 573.509 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 44 |
| T3D0871 | Antimony pentasulfide 1315-04-4 | C30H40N2O7S 572.713 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 20 |
| T3D4032 | Cyclochlorotine 12663-46-6 | C24H31Cl2N5O7 572.438 g/mol |  |
| Cyclochlorotine (CC) causes hepatic necrosis and has carcinogenic properties. The in vitro application of CC on myocytes induced disruption of myofibrils and large acc...more Number of Targets: 0 |