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Browsing Toxins
Displaying toxin 301 - 325 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1128 | Manganese chloride 7773-01-5 | C34H52O5 540.774 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D2527 | Batrachotoxin 23509-16-2 | C31H42N2O6 538.675 g/mol |  |
| Batrachotoxins act on sodium channels by modifying both their ion selectivity and voltage sensitivity. By increasing the permeability of the cell membrane, the cell is...more Number of Targets: 14 |
| T3D2991 | Ambenonium 7648-98-8 | C28H42Cl2N4O2 537.564 g/mol |  |
| Ambenonium is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 1 |
| T3D1840 | Thallium selenide 12039-52-0 | O3SeTl2 535.720 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1562 | Tris(dodecyl)aluminum 1529-59-5 | C36H75Al 534.962 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D4858 | Acid yellow 23 1934-21-0 | C16H9N4Na3O9S2 534.363 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D3691 | Ergovaline 2873-38-3 | C29H35N5O5 533.619 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 7 |
| T3D3709 | Roridin A 14729-29-4 | C29H40O9 532.623 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D2961 | Ketoconazole 65277-42-1 | C26H28Cl2N4O4 531.431 g/mol |  |
| Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergoste...more Number of Targets: 26 |
| T3D3656 | Ditridecyl phthalate 119-06-2 | C34H58O4 530.822 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D3650 | Diisotridecyl phthalate 68515-47-9 | C34H58O4 530.822 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D3710 | Roridin D 14682-29-2 | C29H38O9 530.607 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3865 | Iodosulfuron-methyl-sodium 144550-36-7 | C14H13IN5NaO6S 529.242 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D3712 | Satratoxin H 53126-64-0 | C29H36O9 528.591 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3864 | Indoxacarb 173584-44-6 | C22H17ClF3N3O7 527.834 g/mol |  |
| It is thought that indoxacarb's aromatic metabolites biotransform to active intermediates that produce methemoglobin (A15207). The mechanism of indoxacarb-induced rena...more Number of Targets: 30 |
| T3D2861 | Daunorubicin 20830-81-3 | C27H29NO10 527.520 g/mol |  |
| Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between b...more Number of Targets: 7 |
| T3D3102 | Bromadiolone 28772-56-7 | C30H23BrO4 527.405 g/mol |  |
| Bromadiolone inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so...more Number of Targets: 1 |
| T3D0381 | Cadmium phosphate 13477-17-3 | Cd3O8P2 527.176 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D3745 | Territrem B 70407-20-4 | C29H34O9 526.575 g/mol |  |
| Territrem B is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 2 |
| T3D1767 | Tungsten(VI) oxytetrabromide 13520-77-9 | Br4H4OW 523.490 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D3101 | Brodifacoum 56073-10-0 | C31H23BrO3 523.417 g/mol |  |
| Brodifacoum inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so ...more Number of Targets: 1 |
| T3D3731 | Rubratoxin A 22467-31-8 | C26H32O11 520.526 g/mol |  |
| Rubratoxin A is a potent inhibitor of protein phosphatase 2A, exerting antitumor and antimetastatic effects. Inhibition may cause the phosphorylation of CREB and subse...more Number of Targets: 12 |
| T3D3081 | (-)-Gossypol 90141-22-3 | C30H30O8 518.554 g/mol |  |
| Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind cal...more Number of Targets: 23 |
| T3D3730 | Rubratoxin B 21794-01-4 | C26H30O11 518.510 g/mol |  |
| Rubratoxin B is cytotoxic, hinders cell proliferation, and induces apoptosis. It also inhibits the activity of matrix metalloproteinase-2 and -9. Rubratoxin B causes d...more Number of Targets: 20 |
| T3D3778 | Paspalitrem B 63764-58-9 | C32H39NO5 517.656 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 27 |