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Browsing Toxins
Displaying toxin 3401 - 3425 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0176 | Carbon disulfide 75-15-0 | CS2 76.141 g/mol |  |
| Carbon disulfide is a potent nerve toxin and also affect liver enzymes, particularly those related to lipid metabolism. The increases in serum cholesterol that are som...more Number of Targets: 3 |
| T3D4891 | Thiourea 62-56-6 | CH4N2S 76.121 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0760 | Ammonium thiocyanate 1762-95-4 | CH4N2S 76.121 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D3881 | Methyl cellusolve 9004-74-4 | C3H8O2 76.094 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D4778 | Propylene glycol 57-55-6 | C3H8O2 76.094 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4767 | Hydroxyurea 127-07-1 | CH4N2O2 76.055 g/mol |  |
| Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active sit...more Number of Targets: 2 |
| T3D3660 | Glycolic acid 79-14-1 | C2H4O3 76.051 g/mol |  |
| Glycolic acid's toxicity is due to its metabolism to oxalic acid. Glycolic and oxalic acid, along with excess lactic acid, are responsible for the anion gap metabolic ...more Number of Targets: 1 |
| T3D4164 | Trimethylamine N-oxide 1184-78-7 | C3H9NO 75.110 g/mol |  |
| Uremic toxins such as TMAO are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate th...more Number of Targets: 3 |
| T3D4318 | Glycine 56-40-6 | C2H5NO2 75.067 g/mol |  |
| In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding ...more Number of Targets: 31 |
| T3D0666 | Cobalt(II) oxide 1307-96-6 | CoO 74.933 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D0001 | Arsenic 7440-38-2 | As 74.920 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 46 |
| T3D1543 | Titanium aluminide 12003-96-2 | AlTi 74.849 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1417 | Nickel trioxide 1314-06-3 | NiO 74.693 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D4731 | Potassium Chloride 7447-40-7 | ClK 74.551 g/mol |  |
| Supplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels. Number of Targets: 6 |
| T3D4970 | Sodium hypochlorite 7681-52-9 | ClNaO 74.442 g/mol |  |
| Sodium hypochlorite is a strong oxidizer. Oxidation reactions are corrosive, solutions burn skin and cause eye damage, especially when used in concentrated forms. In p...more Number of Targets: 0 |
| T3D0255 | Ethyl ether 60-29-7 | C4H10O 74.122 g/mol |  |
| Diethyl ether inhibits alcohol dehydrogenase. This slows down the metabolism of ethanol and also inhibits the metabolism of other drugs requiring oxidative metabolism....more Number of Targets: 8 |
| T3D0199 | N-Nitrosodimethylamine 62-75-9 | C2H6N2O 74.082 g/mol |  |
| The mechanism of NDMAinduced liver toxicity is not clearly understood but may be related to alkylation of cellular protein. (L1207) Number of Targets: 0 |
| T3D4444 | Propionic acid 79-09-4 | C3H6O2 74.079 g/mol |  |
| In healthy individuals, the enzyme propionyl CoA carboxylase converts propionyl CoA to methylmalonyl CoA. This is one step in the process of converting certain amino a...more Number of Targets: 2 |
| T3D4224 | Glycidol 556-52-5 | C3H6O2 74.079 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4442 | Glyoxylic acid 298-12-4 | C2H2O3 74.036 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D1507 | Aluminium(I) oxide 12004-36-3 | Al2H4O 73.994 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D4214 | Diethylamine 71247-25-1 | C4H11N 73.137 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0780 | Methyl isothiocyanate 556-61-6 | C2H3NS 73.117 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 43 |
| T3D1674 | Methyl thiocyanate 556-64-9 | C2H3NS 73.117 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D4170 | Methylguanidine 471-29-4 | C2H7N3 73.097 g/mol |  |
| Uremic toxins such as methylguanidine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can s...more Number of Targets: 3 |