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Displaying toxin 3576 - 3600 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D2580Mastoparan (Vespa tropica)
72093-21-1
Not Available
1625.055 g/mol
T3d2580
  • Amide
  • Amine
  • Animal Toxin
  • Insect Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the rele...more
Number of Targets: 0
T3D2581Hongotoxin
203526-59-4
Not Available
4226.080 g/mol
T3d2581
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Scorpion Toxin
Hongotoxin inhibits voltage-gated potassium channels. (L1049)
Number of Targets: 4
T3D2582Maurocalcin
269745-22-4
Not Available
3864.570 g/mol
T3d2582
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Scorpion Toxin
Maurocalcin potently and reversibly modifies channel gating behaviour of the type 1 ryanodine receptor by inducing prominent subconductance behaviour. (T170)
Number of Targets: 1
T3D2584Myotoxin (Crotalus viridis viridis)
132821-30-8
Not Available
4827.755 g/mol
T3d2584
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Snake Venom
Myotoxins work by a non-enzymatic mechanism that leads to severe muscle necrosis, causing paralysis and eventually death. They may also modify voltage-sensitive sodium...more
Number of Targets: 14
T3D2585Taipoxin
52019-39-3
Not Available
13828.660 g/mol
T3d2585
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Snake Venom
Taipoxin causes a gradual reduction to complete stop of evoked and spontaneous release of acetylcholine from motor nerve terminals. (L1106)
Number of Targets: 0
T3D2589Anthopleurin (Anthopleura xanthogrammica)
600880-63-9
Not Available
5137.770 g/mol
T3d2589
  • Amide
  • Amine
  • Animal Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Anthopleurin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of m...more
Number of Targets: 14
T3D2590Calitoxin
118354-83-9
Not Available
8727.960 g/mol
No structure small
  • Amide
  • Amine
  • Animal Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Calitoxin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mamm...more
Number of Targets: 14
T3D2592Edema factor
921236-86-4
Not Available
92477.285 g/mol
T3d2592
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more
Number of Targets: 7
T3D2593Protective antigen
643772-15-0
Not Available
85810.325 g/mol
T3d2593
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more
Number of Targets: 7
T3D2594Lethal factor
159233-86-0
Not Available
93769.580 g/mol
T3d2594
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more
Number of Targets: 7
T3D2595Pertussis toxin
70323-44-3
Not Available
29973.970 g/mol
T3d2595
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
After binding to the cell receptors, pertussis toxin (PTX) is endocytosed and the A moiety translocates into the cytosol where it expresses the ADP-ribosyltransferase ...more
Number of Targets: 6
T3D2596Bifunctional hemolysin/adenylate cyclase (Bordetella pertussis)
566070-83-5
Not Available
177519.955 g/mol
T3d2596
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
After binding of the pertussis AC toxin to the cell, binding to calcium ions leads to the translocation of its adenylate cyclase domain into the cytoplasm, where, upon...more
Number of Targets: 1
T3D2597Toxin A (Clostridium difficile)
Not Available
Not Available
308052.765 g/mol
T3d2597
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more
Number of Targets: 20
T3D2598Toxin B (Clostridium difficile)
Not Available
Not Available
269709.285 g/mol
T3d2598
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more
Number of Targets: 20
T3D2599Alpha-toxin (Clostridium perfringens)
Not Available
Not Available
45529.285 g/mol
T3d2599
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Clostridium perfringens alpha toxin is a zinc metallophospholipase requiring zinc for activation. The C-terminal C2-like PLAT domain binds calcium and allows the toxin...more
Number of Targets: 1
T3D2600Heat-labile enterotoxin (Escherichia coli)
Not Available
Not Available
35330.140 g/mol
T3d2600
  • Amide
  • Amine
  • Bacterial Toxin
  • Food Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Through ADP-ribosylation of a G-protein, heat-labile enterotoxin stimulates adenylate cyclase leading to increased cAMP in epithelial cells. Elevated cAMP levels stimu...more
Number of Targets: 2
T3D2601Perfringolysin O
71329-60-7
Not Available
55829.405 g/mol
T3d2601
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Perfringolysin O binds to cholesterol on eukaryotic cell membranes, then forms oligomeric pores. This causes membrane damage and lysis of the cell. (A2832)
Number of Targets: 1
T3D2602Tetanus toxin
676570-37-9
Not Available
150680.980 g/mol
T3d2602
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
The bacterium synthesizes the tetanus toxin as a single 150kDa polypeptide chain (called the progenitor toxin), that is cleaved extracellularly by a bacterial protease...more
Number of Targets: 1
T3D2605Listeriolysin O
112627-82-4
Not Available
58687.670 g/mol
T3d2605
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Listeriolysin O is a thiol-activated cholesterol-dependent pore forming toxin protein. LLO is selectively activated within the acidic phagosomes of cells that have pha...more
Number of Targets: 1
T3D2606Dermonecrotic toxin (Pasteurella multocida)
Not Available
Not Available
146382.000 g/mol
T3d2606
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Stimulation of several signalling pathways is induced by PMT. Most remarkable is a potent mitogenic effect. Phospholipase C-beta and the small GTPase Rho are activated...more
Number of Targets: 5
T3D2607Exotoxin A (Pseudomonas aeruginosa)
Not Available
Not Available
69283.345 g/mol
T3d2607
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Pseudomonas exotoxin has exactly the same mechanism of action as the diphtheria toxin; it causes the ADP ribosylation of eucaryotic elongation factor 2 resulting in in...more
Number of Targets: 1
T3D2609Shiga toxin subunit A
Not Available
Not Available
34813.360 g/mol
T3d2609
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Shiga toxin causes the glycosidase cleavage of ribosomal eucaryotic 28S rRNA, resulting in inhibition of protein synthesis in susceptible cells. (L1767)
Number of Targets: 1
T3D2610Alpha-hemolysin
94716-94-6
Not Available
35904.070 g/mol
T3d2610
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Alpha-hemolysin consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of...more
Number of Targets: 0
T3D3121Diphtheria toxin (Corynephage omega)
Not Available
Not Available
60814.155 g/mol
T3d3121
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Diphtheria toxin consists of a single polypeptide. Proteolysis yields two fragments (A and B) which are held together by a disulfide bond. The toxin binds to EGF-like ...more
Number of Targets: 1
T3D2611Beta-hemolysin
143257-99-2
Not Available
37237.665 g/mol
T3d2611
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Hemolysins consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of mono...more
Number of Targets: 0
Displaying toxin 3576 - 3600 of 3678 in total