Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3588 | Amanullin 21803-57-6 | C39H54N10O12S 886.971 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D0328 | Lead molybdenum chromate 12709-98-7 | Cr2Mo2O11Pb2 886.300 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 34 |
| T3D1043 | Emamectin B1a 121124-29-6 | C49H75NO13 886.119 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D2645 | Brevetoxin 98112-41-5 | C49H68O14 881.056 g/mol |  |
| Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes. (L1112) Number of Targets: 14 |
| T3D2044 | Nonabromobiphenyl Ether 63936-56-1 | C12HBr9O 880.272 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D4914 | Fd&c red no. 3 16423-68-0 | C20H6I4Na2O5 879.856 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D1556 | Aluminium octadecanoate 637-12-7 | C54H105AlO6 877.389 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D3018 | Rifapentine 61379-65-5 | C47H64N4O12 877.031 g/mol |  |
| Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifape...more Number of Targets: 0 |
| T3D4995 | 22,23-dihydroavermectin b1a 71827-03-7 | C48H74O14 875.093 g/mol |  |
| Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding c...more Number of Targets: 14 |
| T3D1041 | Avermectin B1a 65195-55-3 | C48H72O14 873.077 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D1044 | Emamectin B1b 121424-52-0 | C48H73NO13 872.092 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D1560 | Trieicosylaluminum 1529-57-3 | C60H123Al 871.600 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1548 | Aluminum oleate 688-37-9 | C54H99AlO6 871.342 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D3592 | Proamanullin 54532-46-6 | C39H54N10O11S 870.971 g/mol |  |
| The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more Number of Targets: 14 |
| T3D4042 | alpha-Solanine 20562-02-1 | C45H73NO15 868.059 g/mol |  |
| Solanum glycoalkaloids can inhibit cholinesterase, disrupt cell membranes, and be teratogenic (cause birth defects). One study suggests that the toxic mechanism of sol...more Number of Targets: 0 |
| T3D1992 | 2,2',3,3',4,4',5,5',6-Nonabromobiphenyl 69278-62-2 | C12HBr9 864.272 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1936 | 2,2',3,3',4,5,5',6,6'-Nonabromobiphenyl 119264-63-0 | C12HBr9 864.272 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1935 | 2,2',3,3',4,4',5,6,6'-Nonabromobiphenyl 60586-57-4 | C12HBr9 864.272 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D2473 | Phallisacin 58286-46-7 | C37H50N8O14S 862.903 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D4996 | 22,23-dihydroavermectin b1b 70209-81-3 | C47H72O14 861.066 g/mol |  |
| Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding c...more Number of Targets: 14 |
| T3D1684 | Ferric hexacyanoferrate 14038-43-8 | C18Fe7N18 859.228 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D1042 | Avermectin B1b 65195-56-4 | C47H70O14 859.050 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D4019 | Paclitaxel 33069-62-4 | C47H51NO14 853.906 g/mol |  |
| Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arre...more Number of Targets: 6 |
| T3D4050 | alpha-Chaconine 20562-03-2 | C45H73NO14 852.059 g/mol |  |
| Alpha-Chaconine has inhibitory effect on lung adenocarcinoma cell metastasis in vitro. Alpha-chaconine could inhibit phosphorylation of c-Jun N-terminal kinase (JNK) a...more Number of Targets: 0 |
| T3D2838 | Rifabutin 72559-06-9 | C46H62N4O11 847.005 g/mol |  |
| Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell ...more Number of Targets: 2 |