Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4467 | Chitin 1398-61-4 | C28H49N3O16 683.699 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D3756 | Enniatin A 2503-13-1 | C36H63N3O9 681.900 g/mol |  |
| Enniatins are toxic due to their ability to act as ionophores, changing ion transport across membranes and disrupting the ionic selectivity of cell walls. In the membr...more Number of Targets: 5 |
| T3D1462 | Zinc oleate 557-07-3 | C35H64O4Zn2 679.698 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D4061 | Veratridine 71-62-5 | C36H51NO11 673.790 g/mol |  |
| Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by abolishing inactivation of sodium ion channels. It bind...more Number of Targets: 0 |
| T3D4235 | Aplysiatoxin 52659-57-1 | C32H47BrO10 671.614 g/mol |  |
| Aplysiatoxin is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoter that activates protein kinase C (PKC) (A15358). In cancer cells, PKC isozymes are invo...more Number of Targets: 1 |
| T3D3757 | Enniatin A1 4530-21-6 | C35H61N3O9 667.874 g/mol |  |
| Enniatins are toxic due to their ability to act as ionophores, changing ion transport across membranes and disrupting the ionic selectivity of cell walls. In the membr...more Number of Targets: 5 |
| T3D0873 | Antimony potassium tartrate 28300-74-5 | C8H10K2O15Sb2 667.870 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 23 |
| T3D1852 | Tralomethrin 66841-25-6 | C22H19Br4NO3 665.007 g/mol |  |
| Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more Number of Targets: 20 |
| T3D4438 | Coproporphyrinogen III 2624-63-7 | C36H44N4O8 660.757 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4715 | Teniposide 29767-20-2 | C32H32O13S 656.654 g/mol |  |
| The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DN...more Number of Targets: 1 |
| T3D0351 | Mercury(I) iodide 15385-57-6 | Hg2I2 654.990 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D4323 | Coproporphyrin III 14643-66-4 | C36H38N4O8 654.709 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D3017 | Bromocriptine 25614-03-3 | C32H40BrN5O5 654.595 g/mol |  |
| The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibi...more Number of Targets: 25 |
| T3D3759 | Enniatin B1 19914-20-6 | C34H59N3O9 653.847 g/mol |  |
| Enniatins are toxic due to their ability to act as ionophores, changing ion transport across membranes and disrupting the ionic selectivity of cell walls. In the membr...more Number of Targets: 5 |
| T3D4759 | Liothyronine 6893-02-3 | C15H12I3NO4 650.974 g/mol |  |
| The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid horm...more Number of Targets: 10 |
| T3D3765 | Janthitrem F 90986-52-0 | C39H51NO7 645.825 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 22 |
| T3D3078 | Aconitine 302-27-2 | C34H47NO11 645.737 g/mol |  |
| Aconitine opens voltage-gated sodium channed in the heart and other tissues. (L1235) Number of Targets: 14 |
| T3D4737 | Amiodarone 1951-25-3 | C25H29I2NO3 645.312 g/mol |  |
| The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3) duration and refractory pe...more Number of Targets: 4 |
| T3D2041 | Hexabromobiphenyl Ether 36483-60-0 | C12H4Br6O 643.584 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D1800 | Hexabromocyclododecane 25637-99-4 | C12H18Br6 641.695 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 3 |
| T3D2228 | 2,3,4,6,7,8-Hexabromodibenzofuran 161880-50-8 | C12H2Br6O 641.568 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2162 | 1,2,3,7,8,9-Hexabromodibenzofuran 161880-49-5 | C12H2Br6O 641.568 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2154 | 1,2,3,6,7,8-Hexabromodibenzofuran 107555-94-2 | C12H2Br6O 641.568 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2145 | 1,2,3,4,7,8-Hexabromodibenzofuran 129880-08-6 | C12H2Br6O 641.568 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2137 | 1,2,3,4,6,7-Hexabromodibenzofuran 124388-78-9 | C12H2Br6O 641.568 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |