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Browsing Toxins
Displaying toxin 251 - 275 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4740 | Hexestrol 84-16-2 | C18H22O2 270.366 g/mol |  |
| Not Available Number of Targets: 16 |
| T3D4739 | Imipenem 74431-23-5 | C12H17N3O4S 299.346 g/mol |  |
| Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synth...more Number of Targets: 0 |
| T3D4738 | Encainide 66778-36-7 | C22H28N2O2 352.470 g/mol |  |
| Encainide is a sodium channel blocker, binding to voltage gated sodium channels. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the in...more Number of Targets: 1 |
| T3D4737 | Amiodarone 1951-25-3 | C25H29I2NO3 645.312 g/mol |  |
| The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3) duration and refractory pe...more Number of Targets: 4 |
| T3D4736 | Fludarabine 75607-67-9 | C10H13FN5O7P 365.212 g/mol |  |
| Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluor...more Number of Targets: 4 |
| T3D4735 | Salbutamol 18559-94-9 | C13H21NO3 239.311 g/mol |  |
| Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relax...more Number of Targets: 2 |
| T3D4734 | Salmeterol 89365-50-4 | C25H37NO4 415.566 g/mol |  |
| Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the mol...more Number of Targets: 1 |
| T3D4733 | Quinapril 85441-61-8 | C25H30N2O5 438.516 g/mol |  |
| There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which h...more Number of Targets: 1 |
| T3D4732 | Tacrolimus 104987-11-3 | C44H69NO12 804.018 g/mol |  |
| The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in ato...more Number of Targets: 1 |
| T3D4731 | Potassium Chloride 7447-40-7 | ClK 74.551 g/mol |  |
| Supplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels. Number of Targets: 6 |
| T3D4730 | Medroxyprogesterone Acetate 71-58-9 | C24H34O4 386.524 g/mol |  |
| Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Onc...more Number of Targets: 2 |
| T3D4729 | Diclofenac 15307-86-5 | C14H11Cl2NO2 296.149 g/mol |  |
| The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to ...more Number of Targets: 8 |
| T3D4727 | Streptokinase 9002-01-1 | Not Available 50139.695 g/mol |  |
| Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting ...more Number of Targets: 2 |
| T3D4726 | Alteplase 105857-23-6 | Not Available 62916.495 g/mol |  |
| Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen ...more Number of Targets: 4 |
| T3D4725 | Ozone 10028-15-6 | O3 47.998 g/mol |  |
| Ozone is a strong oxidant and reacts directly with organic double bonds. When ozone breaks down to dioxygen it gives rise to oxygen free radicals, which are highly rea...more Number of Targets: 1 |
| T3D4720 | Zidovudine 30516-87-1 | C10H13N5O4 267.241 g/mol |  |
| Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5ду_-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It...more Number of Targets: 1 |
| T3D4719 | Zalcitabine 7481-89-2 | C9H13N3O3 211.218 g/mol |  |
| Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is conv...more Number of Targets: 0 |
| T3D4718 | Uracil mustard 66-75-1 | C8H11Cl2N3O2 252.098 g/mol |  |
| After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. Number of Targets: 1 |
| T3D4716 | Thiotepa 52-24-4 | C6H12N3PS 189.218 g/mol |  |
| The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. They stop tumor growth by crosslinking guanine nucleobases...more Number of Targets: 1 |
| T3D4715 | Teniposide 29767-20-2 | C32H32O13S 656.654 g/mol |  |
| The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DN...more Number of Targets: 1 |
| T3D4714 | Tamoxifen 10540-29-1 | C26H29NO 371.515 g/mol |  |
| Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the ...more Number of Targets: 12 |
| T3D4712 | Propylthiouracil 51-52-5 | C7H10N2OS 170.232 g/mol |  |
| Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrog...more Number of Targets: 2 |
| T3D4711 | Procarbazine 671-16-9 | C12H19N3O 221.299 g/mol |  |
| The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthe...more Number of Targets: 1 |
| T3D4710 | Prednisone 53-03-2 | C21H26O5 358.428 g/mol |  |
| Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds w...more Number of Targets: 4 |
| T3D4708 | Phenolphthalein 77-09-8 | C20H14O4 318.323 g/mol |  |
| Not Available Number of Targets: 12 |