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Browsing Toxins
Displaying toxin 276 - 300 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4707 | Phenacetin 62-44-2 | C10H13NO2 179.216 g/mol |  |
| Phenacetin's analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it ...more Number of Targets: 1 |
| T3D4705 | Nitrilotriacetic Acid 139-13-9 | C6H9NO6 191.139 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4703 | Metronidazole 443-48-1 | C6H9N3O3 171.154 g/mol |  |
| Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form...more Number of Targets: 1 |
| T3D4702 | Melphalan 148-82-3 | C13H18Cl2N2O2 305.200 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases (primarily at the N-7 position of guanine and to a lesser extent, at t...more Number of Targets: 1 |
| T3D4700 | Lomustine 13010-47-4 | C9H16ClN3O2 233.695 g/mol |  |
| Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-lin...more Number of Targets: 2 |
| T3D4699 | Isopropyl alcohol 67-63-0 | C3H8O 60.095 g/mol |  |
| Not Available Number of Targets: 16 |
| T3D4697 | Iron 7439-89-6 | Fe 55.845 g/mol |  |
| Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia. Number of Targets: 0 |
| T3D4696 | Griseofulvin 126-07-8 | C17H17ClO6 352.766 g/mol |  |
| Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis an...more Number of Targets: 1 |
| T3D4695 | Etoposide 33419-42-0 | C29H32O13 588.557 g/mol |  |
| Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and ...more Number of Targets: 2 |
| T3D4693 | Equilin 474-86-2 | C18H20O2 268.350 g/mol |  |
| Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently incre...more Number of Targets: 6 |
| T3D4690 | Dichloroacetic Acid 79-43-6 | C2H2Cl2O2 128.942 g/mol |  |
| The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase. Thus, it decreases lactate...more Number of Targets: 1 |
| T3D4689 | Dacarbazine 4342-03-4 | C6H10N6O 182.183 g/mol |  |
| The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by ...more Number of Targets: 3 |
| T3D4688 | Cyclophosphamide 50-18-0 | C7H15Cl2N2O2P 261.086 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more Number of Targets: 2 |
| T3D4686 | Cisplatin 15663-27-1 | Cl2H4N2Pt 298.035 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more Number of Targets: 1 |
| T3D4685 | Chloromethyl methyl ether 107-30-2 | C2H5ClO 80.514 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4684 | Chlorambucil 305-03-3 | C14H19Cl2NO2 304.212 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more Number of Targets: 1 |
| T3D4681 | Carmustine 154-93-8 | C5H9Cl2N3O2 214.050 g/mol |  |
| Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds...more Number of Targets: 3 |
| T3D4677 | Azathioprine 446-86-6 | C9H7N7O2S 277.263 g/mol |  |
| Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its...more Number of Targets: 1 |
| T3D4676 | Azacitidine 320-67-2 | C8H12N4O5 244.205 g/mol |  |
| Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mec...more Number of Targets: 3 |
| T3D4675 | Arecoline 63-75-2 | C8H13NO2 155.194 g/mol |  |
| Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has been compared to nicotine; however, nicot...more Number of Targets: 4 |
| T3D4674 | Amsacrine 51264-14-3 | C21H19N3O3S 393.459 g/mol |  |
| Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive...more Number of Targets: 3 |
| T3D4673 | Adapalene 106685-40-9 | C28H28O3 412.520 g/mol |  |
| Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor prot...more Number of Targets: 6 |
| T3D4672 | 4,4'-Methylenedianiline 101-77-9 | C13H14N2 198.264 g/mol |  |
| After 4,4'-Methylenedianiline enters to our body, it is transported in the blood or stored in tissues. The N-N-acetylation of the compound leads to the formation of so...more Number of Targets: 3 |
| T3D4669 | 2,4-Toluenediamine 95-80-7 | C7H10N2 122.168 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4668 | Estradiol 50-28-2 | C18H24O2 272.382 g/mol |  |
| Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has ...more Number of Targets: 8 |