Tmic
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Displaying toxins 201 - 225 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D4790Estriol
50-27-1
C18H24O3
288.381 g/mol
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  • Animal Toxin
  • Drug
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to es...more
Number of Targets: 4
T3D4789Troglitazone
97322-87-7
C24H27NO5S
441.540 g/mol
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  • Amide
  • Amine
  • Drug
  • Ether
  • Organic Compound
  • Synthetic Compound
Troglitazone is a thiazolidinedione antidiabetic agent that lowers blood glucose by improving target cell response to insulin. It has a unique mechanism of action that...more
Number of Targets: 10
T3D4788Simvastatin
79902-63-9
C25H38O5
418.566 g/mol
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  • Anticholesteremic Agent
  • Drug
  • Ester
  • Ether
  • Food Toxin
  • Fungal Toxin
  • Hydroxymethylglutaryl-CoA Reductase Inhibitor
  • Hypolipidemic Agent
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite stru...more
Number of Targets: 10
T3D4787Lovastatin
75330-75-5
C24H36O5
404.540 g/mol
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  • Anticholesteremic Agent
  • Drug
  • Ester
  • Ether
  • Hydroxymethylglutaryl-CoA Reductase Inhibitor
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Lovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hy...more
Number of Targets: 10
T3D4786Didanosine
69655-05-6
C10H12N4O3
236.227 g/mol
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  • Amide
  • Anti-HIV Agent
  • Antimetabolite
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Reverse Transcriptase Inhibitor
  • Synthetic Compound
Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP), which inhibits the HIV rev...more
Number of Targets: 2
T3D4785Benzoic acid
65-85-0
C7H6O2
122.121 g/mol
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  • Animal Toxin
  • Ester
  • Food Preservative
  • Food Toxin
  • Household Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
  • Preservative
Not Available
Number of Targets: 5
T3D4784Clofibrate
637-07-0
C12H15ClO3
242.699 g/mol
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  • Anticholesteremic Agent
  • Drug
  • Ester
  • Ether
  • Hypolipidemic Agent
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are ...more
Number of Targets: 2
T3D4783Nilutamide
63612-50-0
C12H10F3N3O4
317.221 g/mol
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  • Amide
  • Amine
  • Androgen Antagonist
  • Antineoplastic Agent
  • Drug
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Nilutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin that stimulate ...more
Number of Targets: 4
T3D4782Pentadecane
629-62-9
C15H32
212.415 g/mol
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  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Not Available
Number of Targets: 1
T3D4781Hydrochlorothiazide
58-93-5
C7H8ClN3O4S2
297.739 g/mol
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  • Amide
  • Amine
  • Antihypertensive Agent
  • Diuretic
  • Drug
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Sodium Chloride Symporter Inhibitor
  • Synthetic Compound
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tub...more
Number of Targets: 9
T3D4780Theophylline
58-55-9
C7H8N4O2
180.164 g/mol
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  • Amide
  • Bronchodilator Agent
  • Drug
  • Food Toxin
  • Metabolite
  • Muscle Relaxant, Respiratory
  • Organic Compound
  • Phosphodiesterase Inhibitor
  • Purinergic P1 Receptor Antagonist
  • Synthetic Compound
  • Vasodilator Agent
Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, an...more
Number of Targets: 9
T3D4779Pyrimethamine
58-14-0
C12H13ClN4
248.711 g/mol
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  • Amine
  • Antimalarial
  • Antiprotozoal Agent
  • Drug
  • Folic Acid Antagonist
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis a...more
Number of Targets: 10
T3D4778Propylene glycol
57-55-6
C3H8O2
76.094 g/mol
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  • Food Additive
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Solvent
  • Synthetic Compound
Not Available
Number of Targets: 2
T3D4777Isoniazid
54-85-3
C6H7N3O
137.139 g/mol
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  • Amide
  • Amine
  • Antitubercular Agent
  • Drug
  • Ester
  • Fatty Acid Synthesis Inhibitor
  • Food Toxin
  • Hydrazine
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-per...more
Number of Targets: 3
T3D4776Fluorouracil
51-21-8
C4H3FN2O2
130.077 g/mol
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  • Amide
  • Antimetabolite
  • Antimetabolite, Antineoplastic
  • Drug
  • Immunosuppressive Agent
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the dr...more
Number of Targets: 5
T3D4775Fenofibrate
49562-28-9
C20H21ClO4
360.831 g/mol
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  • Drug
  • Ester
  • Ether
  • Hypolipidemic Agent
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of trig...more
Number of Targets: 4
T3D4774Cladribine
4291-63-8
C10H12ClN5O3
285.687 g/mol
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  • Amine
  • Antineoplastic Agent
  • Drug
  • Ether
  • Immunosuppressive Agent
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
Cladribine is structurally related to fludarabine and pentostatin but has a different mechanism of action. Although the exact mechanism of action has not been fully de...more
Number of Targets: 14
T3D4773Capric acid
334-48-5
C10H20O2
172.265 g/mol
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  • Animal Toxin
  • Antifungal Agent
  • Dye
  • Food Toxin
  • Household Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more
Number of Targets: 4
T3D4772Stavudine
3056-17-5
C10H12N2O4
224.213 g/mol
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  • Amide
  • Anti-HIV Agent
  • Antimetabolite
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Reverse Transcriptase Inhibitor
  • Synthetic Compound
Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.
Number of Targets: 1
T3D4771Celecoxib
169590-42-5
C17H14F3N3O2S
381.372 g/mol
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  • Amide
  • Drug
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (C...more
Number of Targets: 7
T3D4770Tioguanine
154-42-7
C5H5N5S
167.192 g/mol
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  • Antimetabolite, Antineoplastic
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to 6-thioguanilyic ...more
Number of Targets: 6
T3D4769Ethanolamine
141-43-5
C2H7NO
61.083 g/mol
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  • Amine
  • Animal Toxin
  • Food Toxin
  • Household Toxin
  • Indicator and Reagent
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
Not Available
Number of Targets: 4
T3D4768Flutamide
13311-84-7
C11H11F3N2O3
276.212 g/mol
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  • Amide
  • Amine
  • Androgen Antagonist
  • Antineoplastic Agent, Hormonal
  • Drug
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamid...more
Number of Targets: 7
T3D4767Hydroxyurea
127-07-1
CH4N2O2
76.055 g/mol
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  • Amine
  • Antineoplastic Agent
  • Antisickling Agent
  • Drug
  • Enzyme Inhibitor
  • Metabolite
  • Nucleic Acid Synthesis Inhibitor
  • Organic Compound
  • Synthetic Compound
Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active sit...more
Number of Targets: 2
T3D4766N-Decane
124-18-5
C10H22
142.282 g/mol
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  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Not Available
Number of Targets: 4
Displaying toxins 201 - 225 of 3678 in total