Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0176 | Carbon disulfide 75-15-0 | CS2 76.141 g/mol |  |
| Carbon disulfide is a potent nerve toxin and also affect liver enzymes, particularly those related to lipid metabolism. The increases in serum cholesterol that are som...more Number of Targets: 3 |
| T3D0177 | 2,3,4,5-Tetrachlorophenol 25167-83-3 | C6H2Cl4O 231.891 g/mol |  |
| Tetrachlorophenols decrease or block ATP production without blocking the electron transport chain. Thus the poisons uncouple phosphorylation from oxidation. Free energ...more Number of Targets: 2 |
| T3D0178 | Americium 7440-35-9 | Am 243.000 g/mol |  |
| Americium toxicity results primarily from the damage done by the alpha particle emitted during radioactive decay. This alpha particle has very limited penetration in t...more Number of Targets: 1 |
| T3D0179 | Uranium-233 13968-55-3 | U 233.040 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D0180 | Palladium 7440-05-03 | Pd 106.420 g/mol |  |
| Palladium ions are able to inhibit most major cellular fuctions. They form strong complexes with both inorganic and organic ligands, substitute essential ions, bind to...more Number of Targets: 5 |
| T3D0182 | Phenol 108-95-2 | C6H6O 94.111 g/mol |  |
| Phenol is irritating and corrosive at high concentrations. Phenol impairs the stratum corneum and produces coagulation necrosis by denaturing and precipitating protein...more Number of Targets: 13 |
| T3D0183 | Chloroethane 75-00-3 | C2H5Cl 64.514 g/mol |  |
| Chloroethane targets the central nervous system and the heart. The lipophilicity of chloroethane suggests it acts upon the lipid layer of cellular membrane or the hydr...more Number of Targets: 2 |
| T3D0184 | Acetone 67-64-1 | C3H6O 58.079 g/mol |  |
| Since acetone is highly water soluble, it is readily taken up by the blood and widely distributed to body tissues. Acetone may interfere with the composition of the me...more Number of Targets: 1 |
| T3D0185 | p-Xylene 106-42-3 | C8H10 106.165 g/mol |  |
| p-Xylene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 4 |
| T3D0187 | Aluminum 7429-90-5 | Al 26.982 g/mol |  |
| The main targets of aluminum are the central nervous system and bones. Aluminum binds to dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The ...more Number of Targets: 6 |
| T3D0189 | Carbon monoxide 630-08-0 | CO 28.010 g/mol |  |
| Carbon monoxide possesses a higher affinity than oxygen for hemoglobin, leading to the formation of carboxyhemoglobin, this provoking anoxemia. Carbon monoxide also bi...more Number of Targets: 30 |
| T3D0191 | Hydrogen sulfide 7783-06-04 | H2S 34.081 g/mol |  |
| Although very pungent at first, hydrogen sulfide quickly deadens the sense of smell, so potential victims may be unaware of its presence until it is too late. Hydrogen...more Number of Targets: 1 |
| T3D0194 | Bis(2-methoxyethyl) phthalate 34006-76-3 | C13H16O4 236.264 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D0195 | Benzyl butyl phthalate 85-68-7 | C19H20O4 312.360 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 11 |
| T3D0196 | o-Cresol 95-48-7 | C7H8O 108.138 g/mol |  |
| Target organs of ingested cresols in humans are the blood, kidneys, lungs, liver, heart, and central nervous system. Cresols impair the stratum corneum and produce coa...more Number of Targets: 3 |
| T3D0198 | Vanadium 7440-62-2 | V 50.940 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cell's phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D0199 | N-Nitrosodimethylamine 62-75-9 | C2H6N2O 74.082 g/mol |  |
| The mechanism of NDMAinduced liver toxicity is not clearly understood but may be related to alkylation of cellular protein. (L1207) Number of Targets: 0 |
| T3D0200 | 1,2,4-Trichlorobenzene 120-82-1 | C6H3Cl3 181.447 g/mol |  |
| Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent...more Number of Targets: 39 |
| T3D0207 | 2,3,7,8-Tetrachlorodibenzofuran 51207-31-9 | C12H4Cl4O 305.972 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D0209 | 2,4-Dichlorophenol 120-83-2 | C6H4Cl2O 163.001 g/mol |  |
| Chlorophenols have moderately high lipophilicity. Absorption through the gastrointestinal tract is by simple diffusion and is expected to be both rapid and virtually c...more Number of Targets: 3 |
| T3D0210 | 1,4-Dioxane 123-91-1 | C4H8O2 88.105 g/mol |  |
| Though the mechanism of toxicity of 1,4-dioxane has not yet been elucidated, it is known that its carcinogenic effects are caused by a non-genotoxic mechanism that is ...more Number of Targets: 4 |
| T3D0211 | Fluorine 7782-41-4 | F 18.999 g/mol |  |
| Fluoride ions are incorporated into bone by substituting for hydroxyl groups in the carbonate-apatite structure to produce hydroxyfluorapatite, thus altering the miner...more Number of Targets: 7 |
| T3D0212 | Nitrite 14797-65-0 | NO2 46.006 g/mol |  |
| Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as meth...more Number of Targets: 9 |
| T3D0213 | Cesium-137 10045-97-3 | Cs 136.907 g/mol |  |
| Highly penetrating gamma rays are the major cause of damage to tissues and internal organs following external overexposure to radioactive cesium. Once radioactive cesi...more Number of Targets: 1 |
| T3D0214 | Silver 7440-22-4 | Ag 107.868 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, resp...more Number of Targets: 18 |