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Platelet-activating factor receptor

NamePlatelet-activating factor receptor
Synonyms
  • PAF-R
  • PAFR
Gene NamePTAFR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019761|Platelet-activating factor receptor
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
Number of residues342
Molecular Weight39203.075
Theoretical pINot Available
GO Classification
Functions
  • phospholipid binding
  • G-protein coupled purinergic nucleotide receptor activity
  • lipopolysaccharide binding
  • lipopolysaccharide receptor activity
  • platelet activating factor receptor activity
  • G-protein coupled receptor activity
Processes
  • immune response
  • interferon-gamma-mediated signaling pathway
  • cytokine production
  • inflammatory response
  • inositol trisphosphate biosynthetic process
  • chemotaxis
  • G-protein coupled receptor signaling pathway
  • G-protein coupled purinergic nucleotide receptor signaling pathway
  • cytokine-mediated signaling pathway
  • phosphatidylinositol-mediated signaling
Components
  • plasma membrane
  • integral component of membrane
  • nucleoplasm
  • integral component of plasma membrane
  • intracellular membrane-bounded organelle
  • membrane
General FunctionPlatelet activating factor receptor activity
Specific FunctionReceptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Pfam Domain Function
Transmembrane Regions17-38 55-74 92-113 134-155 185-205 234-254 277-296
GenBank Protein IDNot Available
UniProtKB IDP25105
UniProtKB Entry NamePTAFR_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019762|Platelet-activating factor receptor (PTAFR)
ATGGAGCCACATGACTCCTCCCACATGGACTCTGAGTTCCGATACACTCTCTTCCCGATT
GTTTACAGCATCATCTTTGTGCTCGGGGTCATTGCTAATGGCTACGTGCTGTGGGTCTTT
GCCCGCCTGTACCCTTGCAAGAAATTCAATGAGATAAAGATCTTCATGGTGAACCTCACC
ATGGCGGACATGCTCTTCTTGATCACCCTGCCACTTTGGATTGTCTACTACCAAAACCAG
GGCAACTGGATACTCCCCAAATTCCTGTGCAACGTGGCTGGCTGCCTTTTCTTCATCAAC
ACCTACTGCTCTGTGGCCTTCCTGGGCGTCATCACTTATAACCGCTTCCAGGCAGTAACT
CGGCCCATCAAGACTGCTCAGGCCAACACCCGCAAGCGTGGCATCTCTTTGTCCTTGGTC
ATCTGGGTGGCCATTGTGGGAGCTGCATCCTACTTCCTCATCCTGGACTCCACCAACACA
GTGCCCGACAGTGCTGGCTCAGGCAACGTCACTCGCTGCTTTGAGCATTACGAGAAGGGC
AGCGTGCCAGTCCTCATCATCCACATCTTCATCGTGTTCAGCTTCTTCCTGGTCTTCCTC
ATCATCCTCTTCTGCAACCTGGTCATCATCCGTACCTTGCTCATGCAGCCGGTGCAGCAG
CAGCGCAACGCTGAAGTCAAGCGCCGGGCGCTGTGGATGGTGTGCACGGTCTTGGCGGTG
TTCATCATCTGCTTCGTGCCCCACCACGTGGTGCAGCTGCCCTGGACCCTTGCTGAGCTG
GGCTTCCAGGACAGCAAATTCCACCAGGCCATTAATGATGCACATCAGGTCACCCTCTGC
CTCCTTAGCACCAACTGTGTCTTAGACCCTGTTATCTACTGTTTCCTCACCAAGAAGTTC
CGCAAGCACCTCACCGAAAAGTTCTACAGCATGCGCAGTAGCCGGAAATGCTCCCGGGCC
ACCACGGATACGGTCACTGAAGTGGTTGTGCCATTCAACCAGATCCCTGGCAATTCCCTC
AAAAATTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9582
Chromosome Location1
LocusNot Available
References
  1. Ye RD, Prossnitz ER, Zou AH, Cochrane CG: Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem Biophys Res Commun. 1991 Oct 15;180(1):105-11. 1656963
  2. Nakamura M, Honda Z, Izumi T, Sakanaka C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M, et al.: Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem. 1991 Oct 25;266(30):20400-5. 1657923
  3. Kunz D, Gerard NP, Gerard C: The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem. 1992 May 5;267(13):9101-6. 1374385
  4. Seyfried CE, Schweickart VL, Godiska R, Gray PW: The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. Genomics. 1992 Jul;13(3):832-4. 1322356
  5. Sugimoto T, Tsuchimochi H, McGregor CG, Mutoh H, Shimizu T, Kurachi Y: Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem Biophys Res Commun. 1992 Dec 15;189(2):617-24. 1281995
  6. Chase PB, Halonen M, Regan JW: Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. Am J Respir Cell Mol Biol. 1993 Mar;8(3):240-4. 8383507
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  9. McLaughlin NJ, Banerjee A, Kelher MR, Gamboni-Robertson F, Hamiel C, Sheppard FR, Moore EE, Silliman CC: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 2006 Jun 1;176(11):7039-50. 16709866
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